Navigation Links
Gene identified that prevents stem cells from turning cancerous
Date:10/14/2010

o survive experimentally induced mutations.

"The increase in the number of hematopoietic progenitor and stem cells in Sept4-deficient mice brings with it the possibility of accelerating the accumulation of mutations in stem cells," says Garcia-Fernandez. "They have more stem cells with enhanced resistance to apoptosis. In the end, that leads to more cells accumulating mutations that cannot be eliminated."

Indeed, the ARTS-deprived mice developed spontaneous tumors at about twice the rate of their controls. "We make a connection between apoptosis, stem cells and cancer that has not been made in this way before: this pathway is critically important in stem cell death and in reducing tumor risk," Steller says. "The work supports the idea that the stem cell is the seed of the tumor and that the transition from a normal stem cell to a cancer stem cell involves increased resistance to apoptosis."

ARTS interferes with molecules called inhibitor of apoptosis proteins (IAPs), which prevent cells from killing themselves. By inhibiting these inhibitors, under the right circumstances ARTS helps to take the brakes off the process of apoptosis, permitting the cell to die on schedule. Pharmaceutical companies are working to develop small molecule IAP antagonists, but this research is the first to show that inactivating a natural IAP antagonist actually causes tumors to grow, Steller says. It also suggests that the premature silencing of the Sept4/ARTS pathway at the stem cell level may herald cancer to come.

"This work not only defines the role of the ARTS gene in the underlying mechanism of mammalian tumor cell resistance to programmed cell death, but also links this gene to another hallmark of cancer, stem and progenitor cell proliferation," said Marion Zatz, who oversees cell death grants, including Steller's, at the NIH's National Institute of General Medical Sciences. "The identification of the ARTS gene and its role in cancer cell deat
'/>"/>

Contact: Brett Norman
bnorman@rockefeller.edu
212-327-7613
Rockefeller University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. 4 kinds of compulsive gamblers identified
2. Hospital readmission studies: Influencing factors identified
3. Parkinsons disease: Excess of special protein identified as key to symptoms and possible new target for treatment with widely used anti-cancer drug imatinib
4. Bacteria identified that may lead to inflammatory bowel disease in certain individuals
5. Tumor budding identified as predictor for unfavorable outcome in lung cancer
6. Novel autoantibodies identified in patients with necrotizing myopathy
7. New sporadic prion protein disease identified by Case Western Reserve
8. Melanoma-initiating cell identified by Stanford scientists
9. Mechanism that may trigger degenerative disease identified
10. New Alzheimers Risk Genes Identified
11. Strange Artifact Identified as Ancient Anti-Snoring Device
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... , ... September 01, 2015 , ... Dr. Trace Curry ... JourneyLite of Cincinnati. In the last month the FDA has approved two intra-gastric ... ™. These procedures represent the first incisionless, reversible, weight loss procedures available to ...
(Date:9/1/2015)... ... September 01, 2015 , ... The integration of Practice Perfect ... Practice Perfect to FOTO enabling cost and time savings, reducing errors and omissions, ... President of Practice Perfect, stated "FOTO is a natural extension of Practice Perfect, ...
(Date:9/1/2015)... ... 2015 , ... Anthony J. Tantillo, Esq., Attorney from William Mattar Law ... year in a row. Through nomination, research and strategic evaluation processes, Tantillo continues ... Falls, New York, Tantillo is a Buffalo State College graduate of 1998. Tantillo ...
(Date:9/1/2015)... ... September 01, 2015 , ... MediNatura™, the ... educational workshop for physician assistants (PAs) practicing in orthopedics. The workshop, titled “Treatment ... held by Dr. Erick Salado, an orthopedic surgeon at South Florida Bone and ...
(Date:9/1/2015)... ... September 01, 2015 , ... The ... Systems, has become a leader in podiatric, surgical and wound care ... Superwounds Conferences place top national speakers at the podium and across the table ...
Breaking Medicine News(10 mins):Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:FOTO Announces New Integration Partnership with Practice Perfect 2Health News:New Hope for Patients Seeking Treatment of Osteoarthritis Knee Pain 2Health News:New Hope for Patients Seeking Treatment of Osteoarthritis Knee Pain 3Health News:PRESENT e-Learning Systems Announces their 2016 Podiatry and Wound Care Medical Education Conference Schedule 2
... to the new study it was found that alcoholics who ... prone to commit suicide. This shows the great// impact of ... show that up to 40 % of patients who seek ... 10 times greater than suicide attempts among the general population. ...
... the study conducted by Jennifer D. Thomas, associate ... it was found that alcohol exposure results// in ... fetal alcohol spectrum disorders (FASD) later in their ... alterations such as altered sleeping,eating patterns, attention deficits, ...
... called fibrodysplasia ossificans progressiva (FOP) has been resolved following ... disease. It is this gene that triggers the formation ... individuals are believed to be afflicted with the disease, ... ligaments, tendons, and plates of bones are imprisoned in ...
... the scientist at the Monell Chemical Senses Center described ... taste by humans. Veronica Galindo-Cuspinera, PhD noted that when ... to taste sweet. Then the researcher found that taste ... are rinsed from the mouth with water, resulting in ...
... as it is commonly called, is a tropical disease that ... soon be able to put an end to this deadly ... vaccine that would protect humans and animals. ,The ... and Brazil. The spleen is the organ to be ...
... latest figures compiled by National AIDS Control Organisation (NACO), using ... that an estimated// 5.21 million adults in India are living ... infected by HIV/AIDS in India has increased. ,Previously, ... 5.13 million people infected by the deadly virus. It is ...
Cached Medicine News:Health News:Alcohol Intake During Pregnancy Is Bad For The Baby’s Hear 2Health News:Rare Bone Disease Traced To Faulty FOP Gene 2Health News:Understanding how humans detect sweet taste 2Health News:Researchers Hopeful About Vaccine For Leishmaniasis 2Health News:HIV/AIDS On The Rise In India 2
(Date:8/31/2015)... Aug. 31, 2015 Pepperl+Fuchs, a world ... MACTek Corporation, a leading provider of HART protocol ... to further extend its integrated solutions offerings and ... "We are pleased to add the ... said Jim Bolin , Pepperl+Fuchs, executive vice ...
(Date:8/31/2015)... 2015 Thousands of people will peacefully demonstrate ... opioid addiction epidemic at dozens of rallies across the ... the United States has experienced ... opioids and heroin, yet the President has never once ... letter to President Obama , rally organizers compared ...
(Date:8/31/2015)... , August 31, 2015 ... that the global cardiovascular monitoring and diagnostic devices ... is predicted to reach a value of approximately ... of 9.7% between 2013 and 2019. The title ... Devices Market (ECG, Holter Monitors, Event Monitors, Cardiovascular ...
Breaking Medicine Technology:Obama Administration's Neglect of Opioid Crisis Prompts Rallies in Many States 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 2Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 3Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 4Cardiovascular Monitoring and Diagnostic Devices Market to Reach US$7.0 Billion in 2019 Owing to Global Rise in Diabetes and Obesity: Transparency Market Research 5
... JERUSALEM , June 2, ... oral drug delivery systems, announced,today that its subsidiary Oramed Ltd. ... ("Laser Detect"), an Israeli company listed on,the Tel Aviv Stock ... Entera Bio Ltd. ("Entera"). Under the terms of the agreement, ...
... Questcor Pharmaceuticals, Inc . (Nasdaq: QCOR ) announced today that it ... June 10, 2010 at The Grand Hyatt Hotel in New York, ... will discuss the Company,s business strategy and historical financial performance at 11:30 ... , Attendance at ...
Cached Medicine Technology:Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd. 2Oramed Pharmaceuticals Forms Joint Venture - Launches Entera Bio Ltd. 3Questcor to Present at the Jefferies 2010 Global Life Sciences Conference 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: