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Gene identified for spread of deadly melanoma
Date:11/4/2010

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Researchers at Washington University School of Medicine in St. Louis have identified a gene linked to the spread of eye melanoma.

Although more research is needed, the researchers say the discovery is an important step in understanding why some tumors spread (metastasize) and others don't. They believe the findings could lead to more effective treatments.

Reporting online in the journal Science Express, the team found mutations in a gene called BAP1 in 84 percent of the metastatic eye tumors they studied. In contrast, the mutation was rare in tumors that did not metastasize.

Metastasis is the most common cause of death in cancer patients, yet little is known about how cancer cells evolve the ability to spread to other parts of the body. There is growing evidence that mutations in so-called metastasis suppressor genes may pro
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Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
Source:Eurekalert  

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