Navigation Links
Gene helps protect tumor suppressor in breast cancer
Date:4/6/2009

HOUSTON - Scientists at The University of Texas M. D. Anderson Cancer Center have discovered a gene that protects PTEN, a major tumor-suppressor that is reduced but rarely mutated in about half of all breast cancers.

The gene Rak helps protect and regulate PTEN, which also is important in several other types of cancer, the team reports in the April edition of Cancer Cell. Causes for diminished PTEN protein levels in breast cancer absent a mutation of the PTEN gene have eluded researchers, who knew for several years that a piece of the puzzle was missing.

"We've clearly discovered the missing link that explains how Rak can stabilize PTEN protein to prevent breast cancer development," said lead author Shiaw-Yih Lin, Ph.D., an assistant professor in the Department of Systems Biology at M. D. Anderson. "Our research explains why PTEN is defective in breast cancer and provides important clues for the development of effective therapy in Rak- or PTEN-defective breast cancers."

In addition to breast cancer, PTEN frequently is mutated or inactivated in glioblastoma, melanoma, and cancers of the prostate and endometrium. The severity of PTEN irregularities strongly correlates with the tumor stage and grade. For example, complete loss of PTEN expression is found more frequently in metastatic cancer than in primary tumors.

In the laboratory, researchers found Rak can stabilize PTEN protein and function as a tumor suppressor gene to prevent breast cancer development.

To examine the correlation between Rak and PTEN protein expression, researchers analyzed cells from 42 breast cancers. Rak expression showed a strong positive correlation with PTEN.

They also investigated the effect of Rak expression by injecting mice with cells that over-expressed Rak. All the mice injected with Rak-overexpressing cells remained tumor free, whereas all the control mice developed tumors.

"To further assess whether Rak is
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Orion Health Concerto Whiteboard Helps Emergency Rooms and Wards Track Patient Status
2. Partnership for Prescription Assistance Celebrates Four-Year Anniversary; Helps More Than 5.7 Million Uninsured Patients Across United States
3. Video: New First Response(R) Fertility Test Helps Women Answer the Question: Am I Able to Get Pregnant?
4. Premium Lens Boot Camp™ Helps Refractive Surgeons Grow Their Premium IOL Practice
5. New Coaching Program Helps Charge Nurses Develop Leadership Skills: B. E. Smith's Coaches Develop High Performers Who Improve Hospital Finances
6. Pennsylvania Department of Health Helps Smokers Trying to Quit in Wake of Federal Cigarette Tax Hike
7. Computer based model helps radiologists diagnose breast cancer
8. VIDEO From Medialink and Siemens: Information Technology Helps Improve Healthcare
9. New Online Program Helps Parents Tackle Childhood Obesity
10. SmartDraw Helps Hospitals Document and Standardize Processes to Achieve Greater Compliance With Regulatory Agencies
11. Drug Combo Helps Larynx Cancer Patients Preserve Voice Box
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene helps protect tumor suppressor in breast cancer
(Date:7/13/2014)... Advanced boilers are preferred over ... of fossil fuels, produce high-capacity power, emit fewer ... global warming and climate change concerns, many countries ... gas emissions and pollutants coming from fossilfuel-based power ... global advance boilers market., The global power rental ...
(Date:7/13/2014)... 2014 MarketsandMarkets recently conducted a ... 3D Scanning; 3D rendering; Layout and Animation; Image ... - 2018)”, which analyzes and studies the major ... Western Europe, Eastern Europe, Middle East and Africa, ... the competitive landscape of the 3D imaging market, ...
(Date:7/13/2014)... Houston, TX (PRWEB) July 13, 2014 The ... for children ranging in age from four months to 12 ... skills and karate classes to birthday parties and Summer Camps, ... the Little Gym of Pearland after spending over ... variety of roles, including Gym Director. , Berry has ...
(Date:7/13/2014)... Recently, 2014QuinceaneraDresses.com, the distinguished special ... new range of gorgeous Quinceanera dresses . ... for elegant Quinceanera outfits is huge. Therefore, 2014QuinceaneraDresses.com ... the company’s newly released dresses are made according ... elegant and vivid. , It is worthy ...
(Date:7/13/2014)... July 13, 2014 Fadhits.com is popular ... prom dresses are extremely beautiful. Recently, the company has ... for 2014. What’s more, all these outfits are ... off). , Additionally, the supplier is now offering ... elegant Quinceanera dresses, it has many other designs for ...
Breaking Medicine News(10 mins):Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 2Health News:North America Advanced Boilers Market is Expected to Reach $518.7billion by 2019 - New Report by MicroMarket Monitor 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2Health News:Fadhits.com Announces a Special Offer on Elegant Quinceanera Dresses 2
... with Roche announcing that its new drug showed positive ... to its key study. Drug maker Roche Holding ... in Europe and the U.S. later this year. ... Co. (4519.TO), which is controlled by Roche. Roche owns ...
... to the Church of England for featuring a prominent British ... the church said Friday. ,The Japanese firm had ... they had not intended to cause offence by using the ... he added. ,"If we have done so, ...
... American socialite and an heiress to a share of the ... for violating// her own probation for a previous offence by ... Angeles Superior Court Judge Michael Sauer rejected Hilton's defense that ... 26-year-old socialite to report to a county detention facility on ...
... star Ben Cousins broke his silence for the first time. Since ... has indeed a problem of substance abuse. ,He revealed ... the past months. He was being treated for a number of ... did not disclose the name of the drug that he had ...
... untreated medical waste dumped in landfills, is emerging from ... Just days from when a significant// amount of hazardous ... fourth catch from another hospital- Los Gatos Surgical Center, was ... Guadalupe landfill during a routine check of regular trash delivered ...
... of Johnstown, Pennsylvania, is recalling half-gallon packages of Galliker's ... milk. Under-processed milk may be unsafe. It has not ... tests on the raw milk itself to determine the ... that it is free of infectious organisms. Only products ...
Cached Medicine News:Health News:New Drug for Rheumatoid Arthritis Looks Promising. 2Health News:Cousins Recovering from His Substance Abuse Problem 2Health News:Hazardous Medical Waste Discovered Again In San Jose 2
(Date:7/11/2014)... 11, 2014  Rock Creek Pharmaceuticals, Inc. (NASDAQ: ... that the Food and Drug Administration ("FDA"), has notified ... RCP,s Investigational New Drug ("IND") application before granting the ... US. Dr. Chris Chapman , RCP,s ... on our IND. When we receive the agency,s official ...
(Date:7/11/2014)... July 11, 2014  Kindred Hospital Houston Northwest, ... the opening of its new outpatient wound healing ... to people with chronic, hard to heal wounds. ... lead to amputation, lower leg wounds related to ... closure, and traumatic injury wounds which are complex ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Issues Update On US Investigational New Drug Application 2Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... . , April 30 A new study, presented at ... , found that Breast-Specific Gamma Imaging (BSGI) is highly accurate in monitoring ... , , ... has been proven in several other studies to improve breast cancer detection ...
... April 29 Warner Chilcott plc (Nasdaq: WCRX ) announced ... market opening on Friday, May 7, 2010 . , ... In addition to issuing a press release, the Company will host a ... 8:00 AM (Eastern Time) to review the results. To participate in the ...
Cached Medicine Technology:BSGI Offers Clear View of Breast Tumor Response to Neoadjuvant Chemotherapy 2Warner Chilcott Announces Earnings Release Date and Conference Call For First Quarter 2010 Financial Results 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: