Navigation Links
Gene found to play a suppressor role in skin cancer development
Date:2/6/2008

Researchers at the Burnham Institute for Medical Research (Burnham Institute) have provided genetic evidence that Activating Transcription Factor 2 (ATF2) plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, which is the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests that it may also play a role in the formation of tumors.

Previous studies led by Zeev Ronai, Ph.D. have suggested an important role of ATF2 in melanoma development and progression. In this new study, published in this weeks issue of Proceedings of the National Academy of Sciences of the United States of America, the Ronai laboratory, in collaboration with Nic Jones, Ph.D. from the University of Manchester UK, used a mouse model that expresses a transcriptionally inactive form of ATF2 in skin cells (keratinocytes). When the mice were subjected to chemically mediated skin carcinogenesis, tumors appeared faster and more frequently. These findings reveal that loss of ATF2 transcriptional activity in skin exposed to carcinogens enhances skin tumor formation, suggesting a tumor suppressor role for ATF2 in keratinocytes.

Important support for the finding comes from the analysis of tumor samples from human patients with non malignant skin cancer, states Dr. Ronai. Unlike the strong nuclear expression of ATF2 in normal skin, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) samples exhibit a significantly reduced nuclear staining for ATF2.

The analysis of human skin cell carcinomas are also consistent with the reduced expression of ATF2 found in the papillomas that developed in the wild-type animals in this study, supporting the notion that ATF2 needs to be inactivated to support skin tumor development.

The group also identified ATF2 as an upstream regulator of genes including Presenilin1 (PS1), Notch1, and -catenin, all of which have previously been reported to be involved in skin tumor development; thus providing an example of a mechanism by which ATF2 functions as a tumor suppressor.


'/>"/>

Contact: Andrea Moser
communications@burnham.org
858-646-3146
Burnham Institute
Source:Eurekalert  

Related medicine news :

1. Very young found to process fear memories in unique way
2. Texas Senator Tommy Williams Honored as Champion for Children by the AMERIGROUP Foundation
3. Foundations to Strengthen State Health Care Reform Advocacy
4. Agatston Research Foundation Sponsors New Childhood Obesity Initiative
5. LOreal USA Announces Three-Year Support of Womens Dermatologic Society Foundation Community Outreach
6. Avon Foundation Brings Together Breast Cancer Experts in Houston to Report Significant New Data
7. 2 genes found to play crucial role in cell survival
8. Model found to determine cause, possible treatment of nerve tumors
9. R Baby Foundation Raises $2.5 Million in First Year
10. Simons Foundation grant boosts brain tumor research
11. The Chrysler Foundation and Kenosha Engine Plant Donate $100,000 to New YMCA Aquatics Center
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene found to play a suppressor role in skin cancer development
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement ... Vice President of North American Capital Sales at HTG Molecular . ... in the commercialization of the HTG EdgeSeq system and associated reagents in North America. ...
(Date:6/24/2016)... FL (PRWEB) , ... June 24, 2016 , ... Finally, ... common after venous procedures, dermaka cream can be incorporated into the post-surgical treatment plans ... minor surgical procedures. , dermaka cream is very effective for bruising and causes ...
(Date:6/24/2016)... AZ (PRWEB) , ... June 24, 2016 , ... SpiritQuest ... the heart of West Sedona, surrounded by famous vortex sites: Cathedral Rock, Airport Mesa, ... from partner properties – the Lodge at Sedona as well as the Sedona Rouge, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: