Navigation Links
Gene findings revealing reasons for neuroblastoma risk
Date:6/17/2009

iants in BARD1 also increased the risk of breast cancer, but no one has found compelling evidence of this," said Maris. "Instead, surprisingly, our genome-wide association studies found that BARD1 is a susceptibility gene for neuroblastoma, and perhaps other cancers as well."

Maris added that researchers are now working to understand the mechanism by which BARD1 gene variants act on developing nervous system cells to give rise to cancer during fetal or early childhood development.

Maris's second study, spearheaded by Dr. Sharon Diskin, also of The Children's Hospital of Philadelphia, found that an inherited CNV located at chromosome 1q21.1 is associated with neuroblastoma. The chromosome region contains a large family of genes that are involved in the development of the nervous system, and the CNV they discovered changes how much of one particular gene is made within normal nerve and neuroblastoma cells.

This study, Maris added, opens up a new area for studying the mechanisms of how CNVs may increase the risk of cancer.

The current findings build on 2008 studies by Maris's lab, one identifying the ALK gene as the major gene predisposing patients to the rare familial form of neuroblastoma, and the other identifying a region of chromosome 6 that increases the risk of the nonhereditary form of the disease. The ALK gene discovery has already led to a clinical trial led by Dr. Yael Mosse of The Children's Hospital of Philadelphia.

As gene studies continue to better define the genetic landscape of neuroblastoma, added Maris, pediatric oncologists can better develop more precise targeted treatments to improve survival and quality of life for children with this complex disease. The Cancer Center at Children's Hospital has one of the nation's largest research and clinical programs in pediatric oncology.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New findings encourage more vigilant monitoring of seizure activity among intensive care patients
2. Perrier Refutes Consumer Council Findings
3. Findings in Epilepsy Gene in Animals May Guide Treatment Directions for Infants
4. Findings in epilepsy gene in animals may guide treatment directions for infants
5. Pitt melanoma researchers present novel findings at ASCO
6. Statement by American Legacy Foundation(R): Findings of Decades of Massive Fraud by Tobacco Industry Upheld in U.S. Court of Appeals
7. HIMSS Analytics and NetMotion Wireless Release Study Findings on Key Challenges for Wireless Healthcare Deployments
8. New Research Finds Recession Has Greater Impact on Health of Parents than Children with Specific Findings on Hispanics
9. New Research Finds Recession Has Greater Impact on Health of Parents than Children With Specific Findings on African Americans
10. Stanford Center on Longevity Releases New Findings About Voter Attitudes on Health Care Reform
11. KLRI Releases 3rd Annual Report On Years Top Longevity Research Findings
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... (PRWEB) April 25, 2015 Parker and Sons ... and cooling, has spiked in Arizona alongside the growing economy. ... additional forty employees for April to help account for the ... forty employees in April is something we are enthusiastic about. ... said Paul Kelly, president at Parker and Sons. , Indeed, ...
(Date:4/25/2015)... 25, 2015 On Friday, April 17, ... Journal’s annual Best Implementation Award. This award is ... best use of RFID technology to improve its manufacturing, ... company that best demonstrates how RFID is delivering real ... RFID Journal Live! 2015 in San Diego, the RFID ...
(Date:4/24/2015)... York, NY (PRWEB) April 24, 2015 ... sober living residence in Westchester County. Just 35 miles ... help transition individuals back into everyday life while recovering ... Thursday, May 7, 2015, will allow therapists, doctors and ... areas and learn more about the opportunities offered by ...
(Date:4/24/2015)... California (PRWEB) April 24, 2015 Ryadon ... a wide range of capabilities and services to complement ... , Ryadon's Quantity Discount Program will be offered on ... follows: , Order 4-19: Receive 10% discount - Order ... by Using the Drawer Slides Products, ...
(Date:4/24/2015)... York (PRWEB) April 24, 2015 ... move forward in the federal multidistrict litigation underway ... According to court documents, the parties involved in ... April 16th detailing, among other things, preparation for ... that counsel for both plaintiffs and defendants have ...
Breaking Medicine News(10 mins):Health News:Parker and Sons Plans to Expand in 2015 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 2Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 3
... have an occasional "bad day" are at increased risk of ... ,It is not uncommon for people over age 70 to ... least half a day and/or cutting back on usual activities ... this is just a normal sign of aging and not ...
... women with endometriosis may one day lead to new ... new research suggests. What's more, the researchers may have ... unfortunate consequence of the condition. ,Anywhere from 10 to ... occurs when the tissue //that lines the uterus, the ...
... biopsy will tell you it’s not a pleasant experience. Now ... for prostate cancer and eliminate the need for unnecessary biopsies ... his prostate after blood tests revealed elevated levels of PSA ... prostate cancer. "Every time they take a section through the ...
... The first major conference on the deadly SARS epidemic ... today. More than 1,000 scientists and clinicians gathered to ... scientific findings and talk about control strategies for a ... infected 8,460. ,The meeting in Kuala Lumpur will also ...
... including non-smokers, are misusing nicotine patches and gum. The authors ... up for health trouble if they smoke and use the ... use the products to maintain their nicotine levels. ,But an ... have lied on the survey. And even if they weren't, ...
... study shows young children with high cholesterol levels are ... and adulthood. Researchers studied the eating habits and cholesterol ... years. The children were examined by doctors and had ... cholesterol, measured periodically. ,Results of the study show children ...
Cached Medicine News:Health News:Teens Misusing Nicotine-Replacement Products 2
(Date:4/24/2015)... , April 24, 2015  Elekta has CE ... Monaco® treatment planning system , enabling European clinics to ... major treatment techniques including advanced 3D planning, IMRT, VMAT ... Monaco ® ... well improved workflow efficiency. Advancements in 3D planning as ...
(Date:4/23/2015)... Calif., April 23, 2015  Edwards Lifesciences Corporation (NYSE: ... heart valves and hemodynamic monitoring, today reported net income ... or $1.12 per diluted share.  Net income for the ... $0.56 per diluted share, and non-GAAP net income was ... Net sales for the quarter ended March 31, 2015 increased ...
(Date:4/23/2015)... - Health Canada is working with the Canadian manufacturers ... information regarding the risk of serious cardiovascular side effects ... used at high doses (at or above 2400 mg/day). ... Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) ... inflammation. The majority of ibuprofen products in ...
Breaking Medicine Technology:Elekta CE marks for Monaco v5.10 treatment planning system 2Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 2Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 4
... Corporation ("Futuremed") (TSX: FMD) and Cardinal Health Canada Inc. ... Inc. (NYSE: CAH ), announced today that ... morning regarding Cardinal Health Canada,s proposed acquisition of all ... for CAD $8.15 per Common Share in cash (the ...
... WORTH, Texas, February 16, 2012 Medical ... in Fort Worth, Texas on March 14-15, 2012. In ... and MD&M East (Philadelphia, PA), MD&M Texas Conference is ... device design and development presented by experienced medtech industry ...
Cached Medicine Technology:Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 2Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 3Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 4Medical Design & Manufacturing Conference to be Launched in Texas in March 2012 2
... Inverness Medical Professional Diagnostics is a ... extensive IFA and DFA test menu that ... and STDs as well as miscellaneous conjugates ... give you a wide assortment of substrates ...
... a leading provider of immunofluorescence assays, with ... that includes kits for autoimmune diseases, infectious ... conjugates and components. Our Impact IFA Test ... substrates and kit sizes to choose from. ...
... Diagnostics is a leading provider of immunofluorescence ... test menu that includes kits for autoimmune ... as miscellaneous conjugates and components. Our Impact ... assortment of substrates and kit sizes to ...
... Inverness Medical Professional Diagnostics is a ... extensive IFA and DFA test menu that ... and STDs as well as miscellaneous conjugates ... give you a wide assortment of substrates ...
Medicine Products: