Navigation Links
Gene find offers hope of screening test for bone disease
Date:5/2/2010

Scientists have discovered three genes linked to the development of Paget's disease, a painful bone condition that affects up to one million people in the UK.

The international team of scientists, led by the University of Edinburgh, believes the genes are involved in regulating the rate at which bone is repaired, providing an explanation of why the disease might occur.

Paget's disease disrupts the body's normal process of breaking down old bone and replacing it. The condition leads to enlarged and malformed bones and patients can suffer from bone pain, brittle bones susceptible to fractures, and advanced arthritis. It affects more people in the UK than anywhere else in the world.

The scientists say that identifying the genes that predispose people to the bone disease could lead to the development of a screening test to identify those most at risk, and improve access to preventative treatment.

Researchers funded by Arthritis Research UK and Paget Association UK studied the genes of 1250 patients with Paget's disease to find the genes that could cause the condition.

The team which included scientists from Spain, UK, New Zealand, and Australia found that three genes that were faulty more frequently in patients with the bone disease than in healthy people.

Together, the faulty genes accounted for the development of Paget's disease in about 70 per cent of cases.

The results published in the journal Nature Genetics confirm that genes play a crucial role in the development of Paget's disease, which explains why many patients have a family history of the condition.

It is hoped that the discovery will allow early detection of the disease and allow doctors to give preventative treatment before bones have become damaged.

Dr Omar Albagha, who performed the study at the University of Edinburgh, said, "These findings represent a major advancement to our understanding of the disease since, until now, only one gene was known to cause about 10 per cent of cases with Paget's disease. The three genes identified from this study contribute to 70 per cent of the disease risk quite unusual in common diseases. We are currently extending our studies to identify the genes responsible for the remaining 20 per cent of the disease risk."

Professor Stuart Ralston, Arthritis Research UK Professor of Rheumatology, who led the project at the University of Edinburgh, said: "Our work shows that these three genes together very strongly predict the development of Paget's disease. Their effects are so powerful that they could be of real value in screening for risk of the disease. This is important since we know that if treatment is left too late, then irreversible damage to the bones can occur. If we were able to intervene at an early stage with preventative therapy, guided by genetic profiling, this would be a major advance."


'/>"/>

Contact: Anna Borthwick
anna.borthwick@ed.ac.uk
44-131-651-4400
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Recorders.com Offers Free Dragon Medical 10.1 Upgrades
2. UPMC Health Plan Offers Brain Fitness Software to Improve Health
3. HeartMath Offers Free Certificates that Celebrate Love and the Heart
4. Saddle Up for a Healthier Trip to the Rodeo! BMI of Texas Offers Healthy Eating Advice for Rodeo-bound Texans
5. Livonia Optometrist Offers New Technology - and New Hope - to Patients ... Free of Charge
6. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
7. Kool Smiles Offers Free Toothbrushes and Education to Day Care Centers Affected by Massachusetts Initiative Supporting Childrens Oral Care
8. The National Christian Foundation Offers to Match Gifts to Haiti
9. Cancer Medicines Pipeline Offers Patients Great Hope
10. Winter Adventurers Look No Further: From Ocean Kayaking To Seal Watching Cruises, Nassau County Offers A Cache Of Cold Weather Thrills
11. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2017)... Wheaton, IL (PRWEB) , ... July 28, 2017 , ... ... recently announced the hiring of associate Jennifer M. Cusack. Ms. Cusack joins ... areas. , Ms. Cusack graduated from Bradley University in Peoria, Illinois, with ...
(Date:7/28/2017)... (PRWEB) , ... July 28, 2017 , ... ... protection and financial planning assistance to families and business owners in and around ... to be held in honor of the Make-A-Wish Foundation. , The Make-A-Wish Foundation ...
(Date:7/27/2017)... ... July 27, 2017 , ... Dr. Adam ... of Oral Implantology/Implant Dentistry (ABOI/ID). After successfully completing an extensive two-day examination in ... dental implants . Dr. Kimowitz and his partner Dr. Hal Kimowitz, practice ...
(Date:7/27/2017)... ... 27, 2017 , ... TransPanel Volume 4 is a collection of animating panel ... exclusive features transitions that contain between 2 and 6 animated panels. Change the direction ... menus. TransPanel Volume 4 makes editing easy in Final Cut Pro X. , TransPanel ...
(Date:7/27/2017)... , ... July 27, 2017 , ... ... services, announces the internal promotion of Elrene Clinkscales to Vice President of Revenue ... & Remittance Management, reporting to Derek Morkel, chief executive officer (CEO). , Elrene ...
Breaking Medicine News(10 mins):
(Date:7/26/2017)... , July 26, 2017 Sancilio Pharmaceuticals ... of our clinical trial evaluating Altemia TM , an ... (SCA) and Sickle Cell Disease (SCD). The SCOT Trial, ... the efficacy and safety of Altemia TM in ... conducted under US IND 125274. ...
(Date:7/24/2017)... July 24, 2017 IBM (NYSE: IBM ) ... Quadrant for Solid-State Arrays (SSA) for the fourth year in ... According to Gartner, "Vendors in the Leaders quadrant have the ... Vision. A vendor in the Leaders quadrant has the market ... the acceptance of new technologies. These vendors demonstrate a clear ...
(Date:7/21/2017)... , July 21, 2017  Endo International plc ... completing a comprehensive review of its manufacturing network, the ... and distribution facilities in Huntsville, Alabama ... take place over the next 12 to 18 months. ... impacted by declining volumes of commoditized products and these ...
Breaking Medicine Technology: