Navigation Links
Gene find offers hope of screening test for bone disease
Date:5/2/2010

Scientists have discovered three genes linked to the development of Paget's disease, a painful bone condition that affects up to one million people in the UK.

The international team of scientists, led by the University of Edinburgh, believes the genes are involved in regulating the rate at which bone is repaired, providing an explanation of why the disease might occur.

Paget's disease disrupts the body's normal process of breaking down old bone and replacing it. The condition leads to enlarged and malformed bones and patients can suffer from bone pain, brittle bones susceptible to fractures, and advanced arthritis. It affects more people in the UK than anywhere else in the world.

The scientists say that identifying the genes that predispose people to the bone disease could lead to the development of a screening test to identify those most at risk, and improve access to preventative treatment.

Researchers funded by Arthritis Research UK and Paget Association UK studied the genes of 1250 patients with Paget's disease to find the genes that could cause the condition.

The team which included scientists from Spain, UK, New Zealand, and Australia found that three genes that were faulty more frequently in patients with the bone disease than in healthy people.

Together, the faulty genes accounted for the development of Paget's disease in about 70 per cent of cases.

The results published in the journal Nature Genetics confirm that genes play a crucial role in the development of Paget's disease, which explains why many patients have a family history of the condition.

It is hoped that the discovery will allow early detection of the disease and allow doctors to give preventative treatment before bones have become damaged.

Dr Omar Albagha, who performed the study at the University of Edinburgh, said, "These findings represent a major advancement to our understanding of the disease since, until now, only one gene was known to cause about 10 per cent of cases with Paget's disease. The three genes identified from this study contribute to 70 per cent of the disease risk quite unusual in common diseases. We are currently extending our studies to identify the genes responsible for the remaining 20 per cent of the disease risk."

Professor Stuart Ralston, Arthritis Research UK Professor of Rheumatology, who led the project at the University of Edinburgh, said: "Our work shows that these three genes together very strongly predict the development of Paget's disease. Their effects are so powerful that they could be of real value in screening for risk of the disease. This is important since we know that if treatment is left too late, then irreversible damage to the bones can occur. If we were able to intervene at an early stage with preventative therapy, guided by genetic profiling, this would be a major advance."


'/>"/>

Contact: Anna Borthwick
anna.borthwick@ed.ac.uk
44-131-651-4400
University of Edinburgh
Source:Eurekalert

Related medicine news :

1. Recorders.com Offers Free Dragon Medical 10.1 Upgrades
2. UPMC Health Plan Offers Brain Fitness Software to Improve Health
3. HeartMath Offers Free Certificates that Celebrate Love and the Heart
4. Saddle Up for a Healthier Trip to the Rodeo! BMI of Texas Offers Healthy Eating Advice for Rodeo-bound Texans
5. Livonia Optometrist Offers New Technology - and New Hope - to Patients ... Free of Charge
6. Renowned Cardiologist Offers Heart Healthy Tips for the Holiday Season
7. Kool Smiles Offers Free Toothbrushes and Education to Day Care Centers Affected by Massachusetts Initiative Supporting Childrens Oral Care
8. The National Christian Foundation Offers to Match Gifts to Haiti
9. Cancer Medicines Pipeline Offers Patients Great Hope
10. Winter Adventurers Look No Further: From Ocean Kayaking To Seal Watching Cruises, Nassau County Offers A Cache Of Cold Weather Thrills
11. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... The iaedp ... and other medical professionals caring for those suffering from the full spectrum of disordered ... 800, as eating disorders professionals from nearly all 50 states and several countries converged ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the standards bearer of ... platform that positions them as the go-to thought leader in all matters concerning ... as an always-on, always-fresh news, views and advocacy engine, called ONS Voice. , ...
(Date:3/24/2017)... ... March 24, 2017 , ... Viewers who like to educate themselves ... facts, cultural practices, goods, services, and societal issues tend to appreciate and love the ... popular practice of utilizing running events for causes around the world. , ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... Walk with God #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true ... How to Walk with God #TruthwithGrace” is the creation of published author Lea ...
(Date:3/24/2017)... ... 24, 2017 , ... “The Adventures of Joey, The Dog Who Barks at ... his life to the fullest, as God intended. “The Adventures of Joey, The Dog ... and grandmother pursuing her passion for writing, especially about truth and human behavior. , ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... and GENEVA , March 24, ... World Tuberculosis Day revitalizes efforts to develop sutezolid as ... On World Tuberculosis Day, TB Alliance and the Medicines ... clinical development of sutezolid, an antibiotic drug candidate which ... to the development of sutezolid in combination with other ...
(Date:3/23/2017)... 2017 Mosaic Life Care, based in St. Joseph, Missouri ... its network of 58 clinics, located in 22 cities, and its flagship St. Joseph ... to improve the delivery of health care to its patients, including the insurance, billing ... ... Mosaic Life Care St. Joseph Medical Center ...
(Date:3/23/2017)... , March 23, 2017  Transportation Insight, a ... an end-to-end supply chain management firm with expertise serving ... Product Solutions Rick Zaffarano was named a ... the Supply Chain by the only publication exclusively dedicated ... food supply chain. "Rick has brought to ...
Breaking Medicine Technology: