Navigation Links
Gene expression test reduces need for invasive heart muscle biopsy
Date:4/26/2010

NEW YORK (April 23, 2010) -- Monitoring rejection in heart transplantation patients with a simple blood test co-developed by NewYork-Presbyterian Hospital/Columbia University Medical Center physician-scientist Dr. Mario Deng in 2005 can safely reduce their need for invasive heart-muscle biopsies, a new study has found.

The multicenter study called Invasive Monitoring Attenuation by Gene Expression (IMAGE) included research by Dr. Deng. Results were presented at the Annual Scientific Meeting of the International Society for Heart and Lung Transplantation in Chicago and are published online in the New England Journal of Medicine today.

Researchers looked at an FDA-cleared gene expression test called AlloMap molecular expression testing, which measures 11 genes from molecular pathways in white blood cells associated with heart transplant rejection. They found the approach was safe, resulted in significantly fewer biopsies compared with a traditional strategy of routine biopsies, and was preferred by patients.

"The genomics revolution initiated by the completion of the Human Genome Project has made possible what was only dreamed about before -- namely the ability to improve patient care by ruling out rejection without taking an invasive heart tissue sample," says Dr. Mario Deng, director of cardiac transplantation research at Columbia University Medical Center, associate professor of medicine at Columbia University College of Physicians and Surgeons and a cardiologist at NewYork-Presbyterian Hospital/Columbia University Medical Center.

After the first year of transplant, heart transplant patients have an average risk of 3 to 5 percent for moderate or severe rejection. Rejection of a transplanted heart can lead to heart damage and eventual failure and loss of life. Consequently, for the rest of their lives, patients must be monitored for rejection to guide their immunosuppressant drug therapy.

Investigators random
'/>"/>

Contact: Jennifer Homa
jeh9057@nyp.org
212-305-5587
New York- Presbyterian Hospital/Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mechanical forces could affect gene expression
2. Hong Kong Government Invites Expressions of Interest in Development of Private Hospitals
3. Personal Tragedy Reveals Untapped Artistic Expression / Family Business Memorializes Loved Ones with Compassion During Grieving
4. New Study Reveals Protein Produced by Spleen Reduces Risk of Deadly Lung Infection
5. Barrow researcher reports that slow breathing reduces pain
6. Researchers find increased dairy intake reduces risk of uterine fibroids in black women
7. Outpatient Palliative Care Reduces Hospitalizations, Which Impact Costs, While Improving Quality of Life for Seniors and Family Caregivers - New Study in American Journal of Managed Care
8. Elastography reduces unnecessary breast biopsies
9. News brief: Knockdown of E2F1 reduces invasive potential of melanoma cells
10. How amyloid beta reduces plasticity related to synaptic signaling
11. Acupuncture reduces hot flashes, improves sex drive for breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... TheCelebrityDresses.com, a popular online store selling ... their summer fashion cocktail dresses. The company carries more ... would be suitable for a wide variety of summer ... designs and make high quality trendy special occasion ... high quality satin, chiffon and cotton. Their products feature ...
(Date:6/2/2015)... 2015 First Choice Emergency Room ... in the United States, named Kenneth Alan Totz, D.O.as ... Road facility. , “We are pleased to announce ... facility,” said Dr. James M. Muzzarelli, Executive Medical Director ... received his undergraduate degree from St. Edwards University in ...
(Date:6/2/2015)... Thermi, formerly ThermiAesthetics, a fast ... transitioned into its new company headquarters in Irving, ... continued rapid worldwide expansion and houses the corporate ... Thermi employees, including those of the warehousing, shipping ... one of the fastest growing aesthetic companies in ...
(Date:6/2/2015)... Join us for a new event in Westwood, ... Rhonda Martin , who overcame her brain aneurysm during the ... to raising awareness and funds for brain aneurysm research. ... that there will be one less case of someone suffering ... to join the 1st Anniversary Awareness Walk in Honor ...
(Date:6/1/2015)... City, NY (PRWEB) June 02, 2015 ... honors Miriam Wirski as a 2015-2016 inductee ... is recognized with this prestigious distinction for leadership in ... for professional women, boasting more than 700,000 members and ... present Miriam with this prestigious honor,” said NAPW President ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Kenneth Alan Totz as New Medical Director of Houston – Jones Road Facility 2Health News:Thermi Moves to New Corporate Headquarters as Rapid Company Expansion Continues 2Health News:New Awareness Raising Event in Westwood, NJ to Benefit Renowned Brain Aneurysm Foundation 2Health News:National Association of Professional Women Inducts Miriam Wirski, Holistic Life Coach, Into its VIP Woman of the Year Circle 2
... Reporter , TUESDAY, July 13 (HealthDay News) -- Patients ... symptoms frequently attributed to memory problems or difficulty finding ... brain disorder may also have a reduced ability to ... from the University of Florida and other institutions showed ...
... content (BMC) as they age than men who are free ... of BJUI . The findings are important because loss ... of fragile bones, fractures and osteoporosis. American researchers studied ... average age of 56 between 1973 and 1984. The maximum ...
... HealthDay Reporter , MONDAY, July 12 (HealthDay News) -- ... open blocked arteries are getting proven treatments in U.S. hospitals ... results of a large-scale study. Data on more than ... January 2007 through June 2009 also showed that the patients ...
... The future health of offspring is more negatively impacted ... nursing compared with high-fat diet consumption during pregnancy, according ... new research results are being presented at the Annual ... Behavior (SSIB), the foremost society for research into all ...
... aggressive infection control measures allowed a Dallas hospital ... type of bacteria that has become increasingly prevalent ... antibiotics. The findings were presented today at the ... Association for Professionals in Infection Control and Epidemiology ...
... Society of America (GSA) the nation,s largest ... has chosen Linda George, PhD, of Duke University as ... Gerontology Award. This distinguished honor is given annually ... about a new synthesis and perspective or have yielded ...
Cached Medicine News:Health News:Emotions May Be Blunted in Alzheimer's Patients 2Health News:Emotions May Be Blunted in Alzheimer's Patients 3Health News:High-risk prostate cancer associated with significantly lower bone mineral content loss 2Health News:Heart Attack Care Is Getting Better, Report Finds 2Health News:Heart Attack Care Is Getting Better, Report Finds 3Health News:Prompt actions halt alarming infection outbreak at Dallas hospital 2Health News:Prompt actions halt alarming infection outbreak at Dallas hospital 3
(Date:6/2/2015)... MADRID , June 2, 2015 ... annuale della American Society of Clinical Oncology    ... di fase 3 SAR3007, resi noti dal dipartimento Ricerca ... evidenziato un significativo miglioramento della sopravvivenza libera da progressione ... rispetto al trattamento con dacarbazina in pazienti con liposarcoma ...
(Date:6/1/2015)... , June 1, 2015  LaunchPad Medical, ... a definitive agreement to license Stryker Corporation,s (NYSE: ... based on a unique synthetic biomaterial.  Under the ... exclusive worldwide license from Stryker for this technology ... pending U.S. patents and includes data from multiple ...
(Date:6/1/2015)... , June 1, 2015  Research Solutions, Inc. (OTCQB: ... and medical (STM) information for life science companies, academic ... to present at the LD Micro Invitational being held ... in Los Angeles . ... on Wednesday, June 3rd at 9:30 a.m. Pacific time, ...
Breaking Medicine Technology:PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 2PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 3PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 4PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 5PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 6LaunchPad Medical Executes Definitive License Agreement with Stryker for Novel Bone Adhesive Technology 2Research Solutions to Present at the LD Micro Invitational on June 3, 2015 2Research Solutions to Present at the LD Micro Invitational on June 3, 2015 3
... LLC has launched a full line of non-prescription, topical ... relief of nerve pain caused by diabetes, post-shingles, chemotherapy, ... the only full line of skin care and pain ... developed from the ground up in oils, lotions and ...
... cites in its newly published " Medical Imaging ... medical imaging equipment exceeded $21 billion in ... Medical imaging can ... computed tomography (CT), positron emission tomography (PET), single ...
Cached Medicine Technology:Affordable Nerve Pain Treatment Now Available in the U.S. 2Global Spending on Medical Imaging Equipment Exceeded $21 Billion in 2010 2Global Spending on Medical Imaging Equipment Exceeded $21 Billion in 2010 3
...
...
...
Open blade speculum designed for both temporal and superior approach ocular surgery. Thumb screw adjusting mechanism. Manufactured in titanium....
Medicine Products: