Navigation Links
Gene expression test distinguishes between breast cancer patients at high and low risk of late recurrence
Date:5/2/2013

Lugano-CH, Brussels-BE, 2 May 2013 -- A test that measures the expression levels of 58 genes in oestrogen receptor-positive breast cancers can effectively differentiate between patients who are at higher and lower risk for having their cancer recur elsewhere in the body more than five years after diagnosis, researchers report.

The new findings show that better individual risk prediction for women with these cancers is getting nearer, says study author Prof Michael Gnant from the Medical University of Vienna, Austria.

Prof Gnant reported the findings at the 5th IMPAKT Breast Cancer Conference in Brussels, Belgium. The IMPAKT meeting presents cutting edge, 'translational' breast cancer research that is beginning to have an impact for patients.

Metastasis after 5 years of follow-up is an important research issue, particularly in hormone-receptor positive breast cancer, Prof Gnant explains.

"Despite all great progress we have made in the treatment of this most frequent subtype of breast cancer, some patients develop metastasis many years after their initial diagnosis. Extending adjuvant endocrine therapy to prevent this is an option, but comes with substantial side-effects and cost for society, and should therefore be reserved for those patients who really need it. Thus, better defining individual risk for late metastasis is an important medical and scientific need," Prof Gnant says.

The PAM50 Risk of Recurrence (ROR) score used by the researchers in this study directly measures the expression levels of 58 different genes (50 discriminator genes and 8 controls).

Prof Gnant and colleagues performed the PAM50 analysis on 1,478 patients who had taken part in the ABCSG-8 trial, which ran from 1996 to 2009. They found that the PAM50 ROR score provided significant prognostic information in addition to clinical factors with respect to late distant-relapse-free survival.

After 11 years of median follow-up
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. McHugh Plastic Surgery & Secret Expressions Med Spa Offer Injection Day Specials
2. Gene-expression signature may signify risk for recurrence, metastasis in prostate cancer
3. Tweaking gene expression to repair lungs
4. Synthetic circuit allows dialing gene expression up or down in human cells
5. Gene expression improves the definition of a breast cancer subtype
6. Gene expression test identifies low-risk thyroid nodules
7. Overexpression of proteins 14-3-3 related to chemotherapy resistance
8. Control of gene expression: Histone occupancy in your genome
9. Changes in gene expression may help explain high blood pressure in pregnancy
10. Gene Distinguishes Early Birds from Night Owls and Helps Predict Time of Death
11. Marker distinguishes more-aggressive from less-aggressive forms of chronic leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... , ... July 28, 2015 , ... ... Total Heart Center at Memorial Regional Hospital, providing expert, streamlined total advanced heart ... be suited to provide extensive heart services under one roof, including the treatment ...
(Date:7/28/2015)... ... July 28, 2015 , ... ... announces Skimmer Helper, a household invention that cleans pools efficiently - minus the ... says Scott Cooper, CEO and Creative Director of World Patent Marketing. "It is ...
(Date:7/28/2015)... Florida (PRWEB) , ... July 28, 2015 , ... ... of patented products, announces Shelled Out, a new household invention that makes shelling ... earn $253.4 billion by 2020,” says Scott Cooper, CEO and Creative Director of ...
(Date:7/28/2015)... ... July 28, 2015 , ... Darryl Worley’s ... volunteers celebrate the 14th year of raising money for the Darryl Worley Foundation. ... for this year’s main concert Saturday, Oct. 3. , This year’s concert will ...
(Date:7/28/2015)... ... ... Morristown Medical Center, part of Atlantic Health System, today announced it was the ... nation, to implant the newly approved CoreValve® Evolut® R System from Medtronic. The system ... , The CoreValve® Evolut® R System was approved by the U.S. Food and Drug ...
Breaking Medicine News(10 mins):Health News:Memorial Cardiac And Vascular Institute Centralizes Cardiac Care Through It's New "Total Heart Center" At Memorial Regional Hospital 2Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 2Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 3Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 4Health News:10 Fascinating Things You Never Knew About Swimming Pools Is Introduced by World Patent Marketing and Skimmer Helper 5Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 2Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 3Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 4Health News:Essential Bang For Your Buck Kitchen Items Presented By World Patent Marketing 5Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 2Health News:Worley’s 14th Tennessee River Run Will Host Wade Hayes, Lorrie Morgan, Tracy Lawrence and Others 3Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 2Health News:Morristown Medical Center First Hospital in New Jersey to Implant Newly Approved Heart Valve 3
... on high alert Wednesday following the first confirmed outbreak of ... thousands of poultry were slaughtered in the Mekong// Delta. ... southern Ca Mau and Bac Lieu provinces, after tests on ... H5N1 strain of avian influenza., ,'We have begun to ...
... conducted by a US research company has highlighted the ... formidable health// problem facing society and their children today. ... 800 adults, found that nearly 27% named 'obesity', as ... insurance followed next with 16% strongly advocating action, ...
... North Carolina at Chapel Hill suggested that low LDL ... ,LDL stands for low density lipoprotein; the low ... Previously associations have been made between LDL and cardiovascular ... Parkinson's disease have a lower occurrence of heart attack ...
... the University of Texas M. D. Anderson Cancer Center suggest ... span of 40 years reduced the tumor growth in the// ... ,The Journal of the National Cancer Institute issued ... drug cromolyn is three times more effective than just the ...
... holding her husband’s hand, says a study. This is indeed ... of marriage// is losing ground. ,A new study ... Virginia, finds that women in a threatening situation show signs ... has been observed in brain scans. ,The researchers, ...
... Andy Kerr will receive Christmas cards from active members ... poor quality of treatment// offered to Chronic Obstructive Pulmonary ... charity suggests that clinical standards be set, to ensure ... ,COPD or Chronic Obstructive Pulmonary Disease is a term ...
Cached Medicine News:Health News:Low LDL Levels Lead to Parkinson's Disease 2Health News:Anti Allergy Drugs Reduce Tumor Growth 2Health News:Anti Allergy Drugs Reduce Tumor Growth 3
(Date:7/28/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cng4gn/refurbished ) has announced the ... Global Forecasts to 2019" report to their offering. ... estimated to grow expected to reach $9.37 billion by ... 2019. Factors such as growing ... increasing privatization in the healthcare sector, and rising adoption ...
(Date:7/28/2015)... July 28, 2015  PD-Rx Pharmaceuticals, Inc., a ... it has partnered with Dobson Technologies, a fully-integrated ... Service (IaaS) product. PD-Rx is an ... the United States.  Using Dobson Technologies, IaaS solution ... business continuity, ensure regulatory compliance, and reduce operating ...
(Date:7/28/2015)... Fla. , July 28, 2015  For many ... their researchers, physicians and other inventors can be a ... market is difficult, and successes are rare. ... wants to change that. Medical Device Investments ... licensed from universities, hospitals and physicians. MDI develops, manufactures ...
Breaking Medicine Technology:Refurbished Medical Equipment Market 2015 - Global Forecasts to 2019 2PD-Rx Partners With Dobson Technologies 2Medical Device Investments To Become Center Of Excellence For The Commercialization Of Innovative Medical Technologies 2
... Texas Children,s Hospital and SynCardia Systems, Inc. announced today ... hospital to complete the first phase of certification to ... intends to use the Total Artificial Heart as a ... heart transplant as children and now require mechanical support ...
... 2011 As the biopharmaceutical marketplace has evolved, leading ... to change as well. Specifically, Market Research is shifting ... shaping strategic objectives for key commercial groups. ... increasingly use new and innovative tools such as Webcams ...
Cached Medicine Technology:Texas Children's Is First Pediatric Hospital To Begin Certification Process for SynCardia's Total Artificial Heart 2Texas Children's Is First Pediatric Hospital To Begin Certification Process for SynCardia's Total Artificial Heart 3Strategic Role Becoming Critical Part of Market Research Function 2
...
...
... At the entry-level, Philips Zymed 1810 Series ... preview, which gives the operator the flexibility ... complex arrhythmia. Choose an application beyond the ... flexibility. Select the interactive or automatic style ...
... Holter Software for Windows is a ... to install, use and maintain as ... comprehensive as a cardiograph., ,Full ... and QuickScan, which combines the benefits ...
Medicine Products: