Navigation Links
Gene expression differences between Europeans and Africans affect response to drugs, infections
Date:2/28/2008

Differences in gene expression levels between people of European versus African ancestry can affect how each group responds to certain drugs or fights off specific infections, report researchers from the University of Chicago Medical Center and the Expression Research Laboratory at Affymetrix Inc. of Santa Clara, CA.

In the March 7, 2008, print issue of American Journal of Human Genetics, and published early online, the researchers used Affymetrix exon arrays to show that expression levels for nearly five percent of the 9,156 human genes they studied varied significantly between individuals of European and African ancestry. The research team took an unbiased whole genome approach and found significant differences in several unrelated processes, especially among genes involved in producing antibodies to potential microbial invaders.

The researchers used lymphoblastoid cell lines derived from blood from 180 healthy individuals. They studied 60 nuclear families, including mother, father and child. Thirty of the families were Caucasians from Utah and 30 were Yorubans from Ibadan, Nigeria.

"Our primary interest is the genes that regulate how people respond to medicines, such as cancer chemotherapy," said cancer specialist Eileen Dolan, PhD, professor of medicine at the University of Chicago and senior author of the study. "We want to understand why different populations experience different degrees of toxicity when taking certain drugs and learn how to predict who might be most at risk for drug side effects."

But in the process they saw several other differences. Some, including variation in the immune system's response to microbial invaders, were expected. Previous studies have found that African Americans may be more susceptible than Caucasians to infection by certain bacteria, such as Porphyromonas gingivalis that causes periodontitis.

Others were unanticipated, including significant differences in expression levels among genes involved in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch-signaling--part of a complex system of communication that governs basic cellular activities and coordinates cell actions.

"Population differences in gene expression have only recently begun to be investigated," said Dolan, "We believe they play a significant role in susceptibility to disease and in regulating drug response. Our current research focuses on how these genetic and expression differences play a role in sensitivity to adverse effects associated with chemotherapy."

Understanding at the genetic level how individuals within and among populations vary in their response to drugs could improve treatment. The University of Chicago team worked closely with Affymetrix on new technology that enabled them to perform a very comprehensive study including evaluation of expression levels of every known gene.


'/>"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Related medicine news :

1. Altered expression of ultraconserved noncoding RNAs linked to human leukemias and carcinomas
2. 10th Anniversary of Revolutionary Teaching Approach that Offers the Severely Disabled the Gift of Self-Expression - Through Painting
3. New study shows that therapeutic gene expression can be sustainable for 1 year
4. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
5. Flip-flopping gene expression can be advantageous
6. Facial expressions have greater impact on kids with bipolar disorder
7. Biolytix to Offer Industrial Gene Expression Analysis and Genotyping Services Using Affymetrix GeneChip(R) Technology
8. iNOS expression may links chronic biliary inflammation to malignant transformation
9. How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
10. Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
11. NEJM editorial on significance and limitations of new lupus gene expression research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 26, 2016 , ... Connor Sports, through its Connor Cares initiative, ... Tamika Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame ... in all forms and levels of the game, Connor Sports has committed to a ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... a significant negative impact on long-term patient survival, reports a team of UPMC ... online this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... development solutions for drugs, biologics, consumer health and global clinical supply services, today ... Korea to support the company’s continued investment and strategic growth plans in the ...
(Date:5/26/2016)... ... ... In an effort to provide hair restoration information to the widest possible audience, Dr. Parsa ... not use the app. Dr. Mohebi, the founder of Parsa Mohebi Hair Restoration, is making ... , Dr. Mohebi says, “The positive response to the Snapchat videos we started last month ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... provider of comprehensive treatment for eating disorders, is opening a brand new child ... provide individuals ages 8-17 and their families with even more specialized eating disorder ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LONDON , May 24, 2016 ... erfüllt beide primären Endpunkte ... und Überlegenheit in ‚ausgezeichneter plus guter ... aufsteigenden Colons    ,      (Logo: ... B.V. gab heute neue positive Daten von der ...
(Date:5/24/2016)... Zealand , May 24, 2016 ... informatics solutions for the healthcare sector, has been named the ... Zealand Hi-Tech Awards 2016. Dr Bruce Davey ... acknowledgement for our team.  It,s really good to be recognised ... healthcare internationally. Our products are used in 35 countries around ...
(Date:5/24/2016)... -- Joe Marziani has joined VMS BioMarketing as senior vice president of sales, announced ... role, Marziani will lead the company,s business development and sales team, exploring new opportunities ... Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: