Navigation Links
Gene combinations and interactions affect risk of Crohn's disease
Date:8/23/2013

Philadelphia, Pa. (August 22, 2013) A statistical model accounting for dozens of different genes in combinationand the interactions between themis an important step forward in understanding the genetic factors affecting the risk of Crohn's disease (CD), reports a study in Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA). The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

It's not just how many risk genes are present but how those genes interact with each other that determines the inheritance of CD risk, suggests the report by a research group from the Cleveland Clinic and University of Pittsburgh. The study is the first to show that information on genetic interactions can improve the ability to predict CD risk and explain its genetic heritability.

New Model of 'Cumulative Genetic Effects and Interactions' Crohn's disease is a chronic inflammatory bowel disease affecting up to 700,000 Americans. Although the exact cause is unknown, CD appears to result from an "inappropriate persistent immune response." In addition to genetics, microbial and environmental factors likely play important roles in the development of CD.

Using modern genetic research methods, called genomewide association studies (GWAS), researchers have identified at least 71 genes that appear to affect CD risk. However, individual genes have only small effects on CD risk. Even after accounting for the combined effects of CD risk genes, less than one-fourth of CD heritability can be explained.

To address this issue, the researchers developed a new model exploring "higher-order genetic interactions" among known CD risk genes. The model was designed to
'/>"/>

Contact: Connie Hughes
connie.hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Learn How to Incorporate Ayruveda into Yoga Practices, Discover Dosha Combinations, and How to Live in Balance this Saturday, May 18th at The YogaSoul Center
2. Different drug combinations work best for prevention versus treatment of colorectal tumors
3. Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
4. Moffitt Cancer Center researchers test drug combinations to prevent graft vs. host disease
5. Interactions between drugs can also be measured at lowest doses
6. Survey shows medical students have frequent interactions with pharmaceutical companies
7. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
8. Novel technique demonstrates interactions between malaria parasite and HIV
9. Study: Disease caused by repeat brain trauma in athletes may affect memory, mood, behavior
10. The Senior Citizens League Warns Chained CPI Affects More Than COLAs, Seniors Would Get Less, Pay More
11. Does chronic pain affect a spouses sleep?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 According to a new market ... Market (Neurosurgical Navigation Systems, ENT Navigation Systems and Orthopedic ... Trends and Forecast 2014 - 2020", the global surgical ... in 2013 and is expected to grow at a ... an estimated value of USD 295.5 million in 2020. ...
(Date:8/27/2014)... The National League for Nursing is pleased ... FAAN, became the inaugural director of the NLN/Chamberlain ... Science of Nursing Education , effective August 11. The ... Home for Transformative Excellence, established with the League’s historic ... , Under Dr. Dennis’s leadership, the NLN/Chamberlain Center will ...
(Date:8/27/2014)... Delta, a reliable supplier of high ... Cat D7R Dozers to its used bulldozer ... announced that all these items are offered with deep ... expand Delta’s market share in the coming September. ... special offer; he has much confidence in the discounted ...
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 Millennium ... now a sponsor for Florida Mental Health Counselors Association ... benefits the new sponsorship is sure to provide. , ... professional needs of Florida’s licensed mental health counselors. The ... the American Counseling Association (ACA) and since then, it ...
(Date:8/27/2014)... NY (PRWEB) August 27, 2014 The ... Team ) is holding free events about “ Sexuality ... speaker Liz Treston. These straightforward and entertaining discussions are ... at Bussani Mobility (501 Concord Avenue, Mamaroneck, NY) and ... Central Avenue, Bethpage, NY). , The New York ...
Breaking Medicine News(10 mins):Health News:Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 2Health News:Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 2Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 4Health News:Reliable Supplier Delta Adds New Items To Its Used Bulldozer Collection 2Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Bussani Mobility Sponsors New York Mobility Club Meetings September 9 & October 7 for People with Disabilities, Sexuality & Intimacy Discussed by Advocate Liz Treston 2
... Not Meeting Daily Physical,Activity Recommendations, INDIANAPOLIS, May ... homes are unlikely to be meeting physical activity,recommendations ... today,at the 55th Annual Meeting of the American ... family child care homes, as the second,largest child ...
... to Fitness, INDIANAPOLIS, May 30 If walking seems ... a stroll is,an easy way to lower pressure and for ... presented findings today at the,55th Annual Meeting of the American ... obese patients was designed to determine if,brisk walking alone was ...
... To Be Completed Within Automatic Form 10-K Extension ... ... May 30 KV Pharmaceutical Company,(NYSE: KVa/KVb), a fully integrated specialty ... prescription pharmaceuticals,announced today that it expects to complete and file its ...
... deployed in regions of the world where tuberculosis (TB) ... military now faces a growing medical problem. But it ... the problem lies with the growing number of pseudoepidemics, ... result of universal testing with a notoriously inaccurate tuberculin ...
... 30 The new University of,Detroit Mercy School of ... Saturday, May 31 from 9 a.m. to 1 p.m. ... offering free dental screenings for community,members, as well as ... held in celebration of the School of Dentistry,s 75th,Anniversary., ...
... MD, RDMS, of Christiana Care Health System, Wilmington, DE, ... with immediate access to patient medical records during a ... radiofrequency devices that electronically contain a persons medical records ... reduce medical charges, two often incompatible goals. , ...
Cached Medicine News:Health News:Preschoolers in Family Child Care Homes Need More Activity 2Health News:Brisk Walking Lowers Blood Pressure, Increases Fitness in Obese 2Health News:KV Pharmaceutical Company Updates Timing of Fiscal 2008 Securities and Exchange Commission Filings 2Health News:KV Pharmaceutical Company Updates Timing of Fiscal 2008 Securities and Exchange Commission Filings 3Health News:US soldiers in high-tuberculosis areas face new epidemic: false positives 2Health News:UDM School of Dentistry to Host Community Open House 2
(Date:8/27/2014)... By now, if you haven,t heard about the ... planet. The awareness campaign has brought this devastating disease to ... over $88.5 Million (and counting) for ALS. Every day, more ... starting to as well. One such company, Acorn ... who actually works with ALS sufferers and helps to provide ...
(Date:8/27/2014)... CHICAGO , Aug. 27, 2014  Hill-Rom Holdings, ... listen to a management presentation at the Morgan Stanley ... p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at ... be available one hour after conclusion of the live ...
(Date:8/27/2014)... 27, 2014 North American lighting leader OSRAM ... Award for the new OSRAM ITOS ® PHASER ® ... module for microscopy, endoscopy and surgical head lamps that delivers ... efficacy and lamp life. "We,re honored to be ... most innovative new technologies of the past year," said ...
Breaking Medicine Technology:Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: