Navigation Links
Gene change identifies brain cancer patients that respond better to treatment
Date:5/31/2011

COLUMBUS, Ohio New research proves that a change in a particular gene can identify which patients with a specific kind of brain cancer will respond better to treatment. Testing for the gene can distinguish patients with a more- or less-aggressive form of glioblastoma, the most common and an often-fatal type of primary brain cancer, and help guide therapy, the researchers say.

The prospective study looked at a gene called MGMT in tumors removed from 833 glioblastoma patients. It showed that when the gene promoter is altered by a chemical change called methylation, patients respond better to treatment.

"We show that MGMT methylation represents a new genetic test that can predict clinical outcomes in glioblastoma patients who have been treated with radiation combined with the chemotherapeutic drug temozolomide," says coauthor Dr. Arnab Chakravarti, chair and professor of Radiation Oncology and co-director of the brain tumor program at the Ohio State University Comprehensive Cancer Center Arthur G. James Comprehensive Cancer Center and Richard J. Solove Research Institute (OSUCCC James).

"Clearly, all glioblastomas are not the same. Rather, they are a collection of different molecular and genetic entities that behave uniquely and require personalized treatment," says Chakravarti, who is the translational-research study chair for the study.

Principal investigator Dr. Mark Gilbert, professor of neuro-oncology at M.D. Anderson Cancer Center, will present the research June 5, 2011, at the 2011 American Society of Clinical Oncology annual meeting in Chicago. It comes from a prospective international phase III clinical trial sponsored by the Radiation Therapy Oncology Group (RTOG).

"Our study confirms the prognostic significance of MGMT gene methylation and demonstrates the feasibility of prospective tumor-tissue collection, molecular stratification and collection of patient outcomes in a large transatlantic intergroup trial," Gilbert says.
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Autism changes molecular structure of the brain, UCLA study finds
2. When Pregnant Mom Smokes, Babys DNA May Change
3. Gene expression changes in nasal cells may help identify lung cancer in earliest stages
4. Smokers undergo the same changes in gene expression as patients with COPD
5. Ecstasy associated with chronic change in brain function
6. Climate change analysis predicts increased fatalities from heat waves
7. Adverse changes in sleep duration are associated with lower cognitive scores in middle-aged adults
8. Discovery could change the way doctors treat patients with cancer and autoimmune diseases
9. Nurse Practitioner Counsels Lifestyle Changes as Key to Heart Health
10. Lifestyle Changes Can Slash Blood Fat Levels, Experts Say
11. Climate change psychology: Coping and creating solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... a discovery that turns 160 years of neuroanatomy on ... known to be essential for the fast transmission of ... as ubiquitous as thought, according to a new work ... Cell Institute (HSCI) and the University,s Department of Stem ... Lichtman, of Harvard,s Department of Molecular and Cellular Biology. ...
(Date:4/18/2014)... one of your worst memories? How did it make ... during a negative personal experience, such as how sad ... to emotional distress, especially when you can,t stop thinking ... up, thinking about the context of the memories, rather ... effective way to alleviate the negative effects of these ...
(Date:4/18/2014)... a brain-related discovery that could revolutionize doctors, perception ... opens up the possibility that environmental and/or genetic ... activity that the researchers have identified as helping ... Neuroscience has just published a paper about ... of psychology and his doctoral student John Gaspar, ...
(Date:4/18/2014)... in French . ... and regenerative medicine. A team led by Ludwik Leibler ... Tech) and Didier Letourneur from the Laboratoire Recherche Vasculaire ... demonstrated that the principle of adhesion by aqueous solutions ... soft-tissue organs and tissues. This easy-to-use gluing method has ...
(Date:4/17/2014)... in benign prostate tissue was associated with high-grade, ... found even in those with low prostate-specific antigen ... Cancer Epidemiology, Biomarkers & Prevention , a ... , An analysis of prostate tissue biopsies collected ... the Prostate Cancer Prevention Trial (PCPT) found that ...
Breaking Medicine News(10 mins):Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Scientists discover brain's anti-distraction system 2Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3
... HealthDay Reporter , THURSDAY, Sept. 1 (HealthDay News) -- ... health problem at some point in their life, a new ... them. Mental health issues run the gamut from depression ... suffering presently do not get help, experts say. ...
... Steven Reinberg HealthDay Reporter , THURSDAY, Sept. 1 ... rate of circumcisions for newborn American boys has waned a ... According to the U.S. Centers for Disease Control and Prevention ... 1999 to just under 57 percent by 2008. That data ...
... PHILADELPHIAHalf-matched bone marrow or stem cell transplants for blood ... outcomes. However, a clinical trial conducted at the ... two-step half-match procedure has produced some promising results: the ... patients after three years and 75 percent in patients ...
... in the journal Scientific Reports , a pair of ... of Pharmacy and Pharmaceutical Sciences report that inhibiting the ability ... slows disease progression in a mouse model of multiple sclerosis ... to the myelin sheath, a protective layer surrounding nerve cells. ...
... By Jenifer Goodwin HealthDay Reporter , THURSDAY, Sept. ... when it comes to the microbes that live in your gut. ... high in fats and animal proteins have a certain group of ... people who eat a more plant-based, higher carbohydrate fare favor other ...
... lung cancer nests can help predict the aggressiveness of ... September issue of the Journal of Thoracic Oncology, ... the Study of Lung Cancer (IASLC). Non-small cell ... deaths worldwide; its two major subtypes are adenocarcinoma and ...
Cached Medicine News:Health News:Half of Americans Will Suffer From Mental Health Woes, CDC Says 2Health News:Half of Americans Will Suffer From Mental Health Woes, CDC Says 3Health News:Circumcision Rate Down Slightly in U.S. Hospitals 2Health News:New half-match bone marrow transplant procedure yields promising outcomes for cancer patients 2Health News:New half-match bone marrow transplant procedure yields promising outcomes for cancer patients 3Health News:Starving inflammatory immune cells slows damage caused by multiple sclerosis 2Health News:Helpful Gut Microbes May Differ Based on Diet 2Health News:Helpful Gut Microbes May Differ Based on Diet 3Health News:Fibrous stroma associated with poor prognosis in lung squamous cell carcinoma 2
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: ... concerning composition of matter, biological targets, mechanism of action, ... This patent application describes a novel ... (VSRNAs) which interfere with the basic homeostatic cellular processes ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining ...
(Date:1/15/2014)... , Jan. 15, 2014 ... research report is available in its ... Markets and Technologies for Advanced Drug ... of Administration ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16
... India, Oct. 19 Cardiac Science Corporation (Nasdaq: ... NSE: OPTOCIRCUI] today announced they have entered into a definitive ... all of the outstanding shares of Cardiac Science common stock ... 10% premium to the closing price of Cardiac Science common ...
... 18 Althea Technologies, Inc., a leading provider ... parenteral drug products, announced today that it has ... high-speed syringe filling line.  This line is located ... in San Diego. The expanded capacity complements existing ...
Cached Medicine Technology:Opto Circuits to Acquire Cardiac Science 2Opto Circuits to Acquire Cardiac Science 3Opto Circuits to Acquire Cardiac Science 4Opto Circuits to Acquire Cardiac Science 5Opto Circuits to Acquire Cardiac Science 6Opto Circuits to Acquire Cardiac Science 7Althea Technologies Announces the Installation of a High-Speed Prefilled Syringe Line 2
... of the outstanding features of our Neomax ... Molding Technology. , This manufacturing process allows ... controls the bunching and irritation in the ... wearer. , ,Colors available: Blue, ...
... be the world's most versatile functional knee ... support, or both, Flex is equipped for ... hinges control flexion and extension and its ... being heat-moldable to accommodate changes in leg ...
... Donut is a neoprene alternative, constructed ... polyester Lycra Fabric that allows for ... provides for patellar control. Ideal for ... or irritations. Click here to view ...
... The cool version of the TROM ... range-of-motion and locking capabilities as the full ... warmer climates. The ease of use and ... a variety of protocols following major ligament ...
Medicine Products: