Navigation Links
Gene activity in the brain depends on genetic background
Date:10/19/2010

SEATTLE, Wash.October 18, 2010Researchers at the Allen Institute for Brain Science have found that the same genes have different activity patterns in the brain in individuals with different genetic backgrounds. These findings may help to explain individual differences in the effectiveness and side-effect profiles of therapeutic drugs and thus have implications for personalized medicine. The study is available in this week's online early edition of the Proceedings of the National Academy of Sciences (www.pnas.org).

In this study, the authors compared where in the brain each of 49 different pharmaceutically related genes is expressed, or turned on, in seven genetically distinct groups of mice with known genealogical relationships. By analyzing 203 distinct brain areas over 15,000 thin sections of tissue, they precisely mapped where these genes are active, down to the level of individual cells. The genes all encode molecular targets of well-known pharmaceuticals, such as antidepressants, antipsychotics and pain relievers including Prozac, Imitrex, and Aricept.

More than half of the genes examined showed striking, localized differences in expression patterns between the different genetic groups, or strains, of mice. For example, the dopamine D2 receptor genewhich encodes a target of action of Zyprexa, a drug used for schizophrenia and bipolar disorderis active in a memory-related area called the entorhinal cortex in one strain of mice, but not in two others. Because different parts of the brain have different functions, variations in the localization of gene activity likely have functional implications.

"It is clear that to understand how genes translate to behavioral and other differences between individuals and species, we need to look beyond just the inherited sequences of the genes themselves," said Allan Jones, chief executive officer of the Allen Institute for Brain Science. "Our results show that genetic backgroundthe specific blend of gene variants comprising an individual genomecan influence how the activity of a given gene is regulated and where it is expressed."

Taken all together, the data from the study demonstrate that closer genetic relatives exhibit fewer differences in gene expression patterns, whereas more distant relatives show greater variation. Interestingly, the researchers found that the expression variations between genetic strains were more likely to be found in areas of the brain that evolved more recently. These regions are most commonly linked to higher order functions such as cognition, social behavior, learning and memory.

"This study shows how large-scale datasets can be used to reveal fundamental biological patterns that would likely be missed otherwise," said Jones. "It is likely that many important differences between individuals and species may result from combinations of many small but clear differences in gene expression."

Jones added, "Our ongoing Allen Human Brain Atlas project, which will provide gene expression data across the brains of multiple donors, will help researchers translate these results from an animal model to a human system."


'/>"/>

Contact: Aaron Blank
aaronblank@feareygroup.com
206-343-1543
Allen Institute for Brain Science
Source:Eurekalert

Related medicine news :

1. Resting brain activity associated with spontaneous fibromyalgia pain
2. Children have a negative impact on physical activity among individuals with heart disease
3. Concordia researcher leads study that finds kids reduce physical activity for heart patients
4. Inactivity no contributor to childhood obesity epidemic
5. Teenage physical activity reduces risk of cognitive impairment in later life
6. Abnormal brain activity in migraineurs is not restricted to attacks
7. Targeting disease remission has socio-economic benefits over low disease activity
8. Onrec Predicts Significant Recruiting Activity this Fall
9. BRAF inhibitor shows promising preclinical activity against melanoma
10. Study: Adults take their physical activity on the road
11. Non-intense physical activity to reduce depression and boost recovery of stroke patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... Opelousas, LA (PRWEB) , ... February 12, 2016 , ... ... of St. Landry and Evangeline Parishes. The purpose of these scholarships is to ... to encourage those individuals to seek employment within these two parishes. , “We ...
(Date:2/12/2016)... ... ... Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. – ... who don’t learn from history are doomed to repeat it.” , An analysis of CDRH’s ... But that takes time. , Take a close look at the warning letters the ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... As a ... hectic schedule, a demanding job, and no time to decompress, Rabinowitz found herself drawn ... herself to meditation for its impact on her life, implementing a 20-minute-per-day meditation practice ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... Vegas, NV (PRWEB) , ... February 12, 2016 , ... ... North Las Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, ... Fisher House at the VA Southern Nevada Healthcare System. This will be the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... --  National Community Pharmacists Association (NCPA) CEO ... statement today in response to the detailed "preferred pharmacy" ... Medicare & Medicaid Services (CMS) and conducted in response ... patient advocacy organizations and members of ... CMS analysis. Our initial reaction is that more work ...
(Date:2/12/2016)... 2016 /PRNewswire/ - Demers Ambulances announces its first delivery in the ... Okaloosa County Emergency Medical Services (EMS) consisting of ... LT2 van. Quality Emergency Vehicles in Lecanto, FL ... sale.  This is the latest in Demers, ongoing expansion of ... at Demers. --> Benoit LaFortune , Executive Vice ...
(Date:2/12/2016)... -- Memorial Hermann Health System has teamed up with Houston ... a one-of-a-kind experience to pediatric patients at Children,s ... 360-degree video and Google Cardboard, Howard was able to ... the patients and their families an unexpected, and energetically ... video . Memorial Hermann IRONMAN Sports ...
Breaking Medicine Technology: