Navigation Links
Gene Variants That Boost Lung Cancer Risk Identified
Date:8/18/2011

THURSDAY, Aug. 18 (HealthDay News) -- Two gene variations that increase smokers' risk of lung cancer have been identified by researchers.

Smokers with the variants also tend to smoke more and become more dependent on cigarettes, the Canadian study found.

Researchers at the Centre for Addiction and Mental Health in Toronto looked at 417 current or former smokers with lung cancer and 443 current or former smokers without cancer.

Smokers with the variations in the nicotine metabolic gene (CYP2A6) and the nicotinic gene cluster (CHRNA5-A3-B3) were more likely to have lung cancer, more likely to be more nicotine dependent and were more likely to smoke heavily.

The increased risk of lung cancer among people with both variants was the most pronounced among light smokers who smoke 20 or fewer cigarettes a day, the investigators found.

"While heavier smoking increases the overall risk for lung cancer (as well as other health problems), our study looked specifically at the effects of these two genes on cancer risk," said study author Rachel Tyndale in a news release from the center. "We found the genetic risk from these two genes made a larger contribution among lighter smokers," she noted.

"The nicotine metabolic gene appears to have a larger influence on how many cigarettes people smoke each day, while the nicotinic gene cluster has a larger impact on the risk of lung cancer," Tyndale added.

"The combined effect of having both high-risk gene variations more than doubled the odds of developing lung cancer," she said.

The finding is important because many smokers tend to smoke less than they used to, according to the researchers.

The study is published in the September issue of the Journal of the National Cancer Institute.

More information

The U.S. Centers for Disease Control and Prevention outlines '/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Spotting Gene Variants May Boost Hepatitis C Treatment
2. Mayo-led researchers discover genetic variants modifying breast cancer risk
3. Scientists Spot Gene Variants That Predict Longevity
4. Genetic Variants Tied to MS, Study Finds
5. First Gene Variants Linked to Stuttering Discovered
6. Story Spoilers May Boost Enjoyment
7. Religion Might Boost Happiness in Times of Stress
8. Poorly Controlled Asthma Can Boost Chances of Pregnancy Complications
9. Study finds popular muscle-boosting supplement does not increase blood flow
10. Weight Loss May Boost Sex Life of Obese, Diabetic Men
11. Regular Exercise Boosts the Brain, Too
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2014)... Oct. 1, 2014 (HealthDay News) -- Children with autism ... they,re fully capable of being more active, a small ... levels of 29 children, some with autism and some ... day of moderate physical activity and 70 more minutes ... 17 children with autism scored lower on strength, but ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. 1, ... Columbia now have a total of 500 confirmed cases of ... children since the summer, U.S. health officials reported Wednesday. ... recent weeks, but it,s not clear what role -- if ... Health officials are also trying to determine if the ...
(Date:10/1/2014)... A new research study published today in the ... in patients older than 50 years with moderate or ... benefit. , Researchers from the University of Melbourne randomly ... knee pain to no acupuncture or sham or pretend ... weeks with participants and acupuncturists blinded to laser and ...
(Date:10/1/2014)... New research suggests the adage that encourages people to ... target when it comes to exercise. When walking, staying ... distance to it appear shorter and help people walk ... compares this technique to walking while looking around the ... quality of exercise. , "People are less interested in ...
(Date:10/1/2014)... October 01, 2014 Lifeinsurance-policy.com has ... the best life insurance prices for smokers. , Smoking ... insurance premiums. Comparing quotes is the best method to ... quotes for customers who need coverage. , Whole ... duration of the policy. Since the coverage is permanent, ...
Breaking Medicine News(10 mins):Health News:Kids With Autism Tend to Be Less Active, Study Says 2Health News:42 States Reporting Respiratory Virus That Targets Kids 2Health News:42 States Reporting Respiratory Virus That Targets Kids 3Health News:Study finds acupuncture does not improve chronic knee pain 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Affordable Whole Life Insurance Premiums for Smokers! 2
... blast of gamma radiation could toughen up plastic prosthetic joints ... to researchers in China writing in the current issue of ... joint replacement, such as hip and knee replacement, commonly use ... or diseased bone of the joint. Non-stick polymer or nylon ...
... The kidney performs several vital functions. It filters blood, ... fluids, and releases hormones that regulate blood pressure. A ... filtration apparatus, such as diabetes and immune disorders. This ... is characterized by protein in the urine, high cholesterol ...
... -- Dena S. Cox, a professor of marketing and ... has received a $99,600, two-year research grant from Merck ... human papillomavirus (HPV) vaccine. Cox,s research investigates how ... communication on consumers, adoption of preventive behaviors. In the ...
... Serena Gordon HealthDay Reporter , WEDNESDAY, Sept. 21 ... inoculation against rotavirus -- a leading cause of diarrhea in ... children have been hospitalized and about $278 million in healthcare ... The vaccine targets rotavirus, a common and easily transmitted pathogen. ...
... for medical information? Viewers beware, doctors caution. After ... disorders, a group of neurologists found that the people ... disorder. As described in a Letter to the Editor ... medical misinformation may confuse patients suffering from devastating neurological ...
... Sept. 21 (HealthDay News) -- Traces of radioactive fallout ... earthquake were detected around San Francisco Bay, scientists report, ... risk to residents. A magnitude 9.0 quake severely ... but just how far the radioactive fallout from the ...
Cached Medicine News:Health News:Radiation boost for artificial joints 2Health News:Kidney damage and high blood pressure 2Health News:Indiana U. professor to examine how women respond to information about the HPV vaccine 2Health News:Vaccine for Childhood Diarrhea Helps Kids, Saves Dollars 2Health News:Vaccine for Childhood Diarrhea Helps Kids, Saves Dollars 3Health News:YouTube videos can inaccurately depict Parkinson’s disease and other movement disorders 2Health News:Japan Reactor Fallout Reached San Francisco Bay Area: Study 2
(Date:10/1/2014)... UNION CITY, Calif. , Oct. 1, 2014 /PRNewswire/ ... products company manufacturing point-of-care instruments and consumables for the ... lab services to the veterinary and research markets in ... it has entered into a definitive distribution agreement with ... inventory, market and promote the full line of Abaxis ...
(Date:10/1/2014)... and NOTTINGHAM, England , Oct. ... CBRX ) today announced that its subsidiary, Molecular Profiles ... Trials platform at the annual CPhI/ICSE Worldwide event in ... to support companies with the rapid development of both ... enabling technologies screening platform, which incorporates the company,s existing ...
(Date:10/1/2014)... DIEGO , Oct. 1, 2014 ... molecular diagnostics, announced today that Eli Diamond ... Kettering Cancer Center (MSK), presented clinical data from ... precision cancer monitoring platform for the determination of ... a liquid biopsy.  The results were presented to ...
Breaking Medicine Technology:Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 2Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 3Abaxis Announces Distribution Agreement with Patterson Veterinary Supply 4Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 2Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4
... 9, 2010 Alere Inc. (NYSE: ALR ), ... their health at home through the merger of rapid diagnostics ... Lazard Capital Markets 7th Annual Healthcare Conference being held November ...  Jon Russell, Vice President, Finance, will attend.  Mr. Russell,s presentation ...
... Across the country, thousands of senior citizens and people living ... well enough in their homes to groom themselves, prepare meals ... are often difficult for those in need of mobility assistance, ... For Medicare beneficiaries in need of mobility assistance, the lame-duck ...
Cached Medicine Technology:Congress Urged to Delay New Medicare Wheelchair Rental Policy 2Congress Urged to Delay New Medicare Wheelchair Rental Policy 3Congress Urged to Delay New Medicare Wheelchair Rental Policy 4
For injecting anesthetics into the muscle cone. 23G x 1 1/2 in (.60 x 38mm)...
... This all digital single plane C-arm ... unprecedented cardiac imaging performance and an expansive ... from cardiac angiography to ECG triggered. ... Flat Detector technology,State of the art dynamic ...
... is a complete vestibular diagnostic system ... movements collected via electrodes. Its Windows-based ... use. Saccade, tracking and Slow Phase ... is facilitated by graphic comparison of ...
For diagnostic and operative treatment of hand and wrist bones. The use of this distraction device allows fracture reduction or widening of the space between bones....
Medicine Products: