Navigation Links
Gene Variants Can Predict Threat of Heart Disease

Cholesterol-associated variants increase risk and may be early indication, study shows

WEDNESDAY, March 19 (HealthDay News) -- A combination of cholesterol-associated gene variants can increase a person's risk for heart attack, stroke or sudden cardiac death, Massachusetts General Hospital researchers report.

It may someday be possible to test for these gene variants in order to identify patients who may require more intense monitoring and might benefit from earlier use of cholesterol-lowering medications and other measures to reduce their increased risk for cardiovascular events, the researchers said.

"We feel that our data provides two insights," study lead author Dr. Sekar Kathiresan, director of preventive cardiology at MGH, said in a prepared statement. "First, we provide a foundation for the possibility that a panel of gene variants will eventually be useful in preventive cardiac care. Second, we show that the combination of multiple variants related to cholesterol importantly contribute to the genetic risk for heart attack."

In analysis of data from 5,414 Swedish adults, Kathiresan and colleagues focused on a combination of 9 single-nucleotide polymorphisms (SNPs) previously associated with cholesterol levels. The researchers also looked at the participants' high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels, and their subsequent medical histories.

The participants were given a genotype score, ranged from 0 to 18, based on how many copies of the unfavorable SNPs they had. Those with higher genotype scores had higher LDL (bad) cholesterol and lower HDL (good) cholesterol levels. Those with genotype scores of 11 or higher had a 63 percent greater risk of a cardiovascular event than those with score of nine or lower.

In the overall study population, testing for the panel of nine SNPs was no better than standard risk factors for predicting risk of cardiac events. However, among those classified at intermediate risk by standard measures, the results of testing for the panel of nine SNPs significantly improved the ability to identify people with truly elevated or reduced cardiac event risk levels, the researchers said.

The study appears in the March 20 issue of the New England Journal of Medicine.

"A current clinical dilemma is how early to start patients on cholesterol-lowering medications like statins that can reduce the risk of heart attack," Kathiresan said. "Our data suggest those individuals classified as higher risk based on a genetic test may deserve more intense pharmacological and lifestyle treatments."

However, before this approach can actually be used to help patients, he added, "we need to discover all the risk-related variants -- and there will probably be 50 to 100 -- and then conduct clinical studies confirming that this information can reliably guide patient care."

More information

The U.S. Centers for Disease Control and Prevention has more about heart disease risk factors.

-- Robert Preidt

SOURCES: Massachusetts General Hospital, news release, March 19, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. 10 Million Baby Boomers Face Alzheimers, Report Predicts
2. Heart Risk Can Be Predicted Without Lab Tests
3. Leicester medical team announces predictor for pregnant women who may have miscarriages
4. Genetic Markers May Predict Lung Cancer Recurrence
5. New Test Predicts Risk of Post-Surgery Kidney Injury
6. Biopsy techniques have made PSA test less predictive
7. Bacteria Mix in Guts of Babies Predicts Obesity
8. Launch of Web-based tool to predict risk of bone fracture
9. Estrogen Levels in Blood Predict Breast Cancers Return
10. Genetic Test Predicts Response to Warfarin
11. Researchers develop new tool to predict who will use microbicides
Post Your Comments:
Related Image:
Gene Variants Can Predict Threat of Heart Disease
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent and ... apnea using cutting-edge Oventus O2Vent technology. As many as 18 million Americans ... frequent cessation in breathing. Oral appliances can offer significant relief to about 75 ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in post-acute health care, have expanded their existing home health joint venture through ... AccentCare has been operating a joint venture home health company with Asante, delivering ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, ... relay – Miles by Moonlight to raise money for the American Heart Association Heart ... , Teams will work together to keep their treadmills moving for 5 hours. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ® ... fulfilling the promise of precision medicine, today announced that ... Caris, Precision Oncology Alliance™ (POA) as its 17 th ... the St. Jude Crosson Cancer Institute will help develop ... use of tumor profiling, making cancer treatment more precise ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
Breaking Medicine Technology: