Navigation Links
Gene Variant Tied to Cocaine-Induced Paranoia

Finding may shed light on physiology of phobias in general, study suggests

WEDNESDAY, March 4 (HealthDay News) -- Genetic variants that increase cocaine addicts' risk of paranoia have been identified by U.S. researchers.

In their study of almost 4,000 people of African and European descent, the Yale University and Boston University School of Medicine team examined an area of the genome previously shown to be associated with cocaine dependence and cocaine-induced paranoia.

The researchers conducted a genetic analysis of 11 variants of the a-endomannosidase (MANEA) gene, which metabolizes complex carbohydrates. They found that nine of the variants were linked to cocaine-induced paranoia among African-Americans, and six variants were identified among Americans of European descent.

Variants in this area of the genome were also associated with cocaine dependence.

The study was published in the March issue of the Archives of General Psychiatry.

"We feel that these findings are of great interest because of the novelty of the physiological pathway involved," Dr. Joel Gelernter, a professor of psychiatry, genetics and neurobiology, and director of the Division of Human Genetics in Psychiatry at Yale University School of Medicine, said in a Yale news release.

"This is one of the great advantages of taking a genome-wide approach to discovery of risk variants for complex traits like cocaine-induced paranoia -- you can learn about mechanisms that you would probably have never considered beforehand. This will open a new line of inquiry into the physiology of cocaine-induced paranoia, and possibly into symptoms of paranoia more generally," Gelernter said.

More information

The U.S. National Institute on Drug Abuse has more about cocaine.

-- Robert Preidt

SOURCE: Yale University, news release, March 2, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Variant Allies Autism, Gastrointestinal Woes
2. Gene Variant Raises Risk of Uterine Fibroids
3. Gene Variant Tied to Severity of Drinking
4. Gene Variant Raises Risk for Brain Cancer at Young Age
5. Gene Variant May Hike Womens Risk of Alzheimers
6. Biologist finds plant polymerases IV and V are really variants of Polymerase II
7. Gene Variant Tied to Smokers Risk of Lung Cancer
8. Genetic Variants Tied to Obesity
9. NEW Line of Pushbutton Pill Cases Launched by Variant Products
10. Newly found gene variants account for kidney diseases among African-Americans
11. Genetic variants associated with vitamin B12
Post Your Comments:
Related Image:
Gene Variant Tied to Cocaine-Induced Paranoia
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... agency serving communities in the greater Dallas, Miami, and Raleigh regions, is organizing ... fighting to overcome a rare and deadly chromosome abnormality. , After struggling since ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... While it’s ... poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , ... medication in darkness or restricted lighting. As such, it eliminates the need to turn ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical (AVACEN) ... is now successfully helping those with the widespread pain ... Fibromyalgia diagnosed Amanda in Essex, England ... washing my hair, experiencing no sleep at all, tremendous ... spasm… I cannot recommend [the AVACEN 100] enough, how ...
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
Breaking Medicine Technology: