Navigation Links
Gene Variant Tied to Cocaine-Induced Paranoia
Date:3/4/2009

Finding may shed light on physiology of phobias in general, study suggests

WEDNESDAY, March 4 (HealthDay News) -- Genetic variants that increase cocaine addicts' risk of paranoia have been identified by U.S. researchers.

In their study of almost 4,000 people of African and European descent, the Yale University and Boston University School of Medicine team examined an area of the genome previously shown to be associated with cocaine dependence and cocaine-induced paranoia.

The researchers conducted a genetic analysis of 11 variants of the a-endomannosidase (MANEA) gene, which metabolizes complex carbohydrates. They found that nine of the variants were linked to cocaine-induced paranoia among African-Americans, and six variants were identified among Americans of European descent.

Variants in this area of the genome were also associated with cocaine dependence.

The study was published in the March issue of the Archives of General Psychiatry.

"We feel that these findings are of great interest because of the novelty of the physiological pathway involved," Dr. Joel Gelernter, a professor of psychiatry, genetics and neurobiology, and director of the Division of Human Genetics in Psychiatry at Yale University School of Medicine, said in a Yale news release.

"This is one of the great advantages of taking a genome-wide approach to discovery of risk variants for complex traits like cocaine-induced paranoia -- you can learn about mechanisms that you would probably have never considered beforehand. This will open a new line of inquiry into the physiology of cocaine-induced paranoia, and possibly into symptoms of paranoia more generally," Gelernter said.

More information

The U.S. National Institute on Drug Abuse has more about cocaine.



-- Robert Preidt



SOURCE: Yale University, news release, March 2, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Variant Allies Autism, Gastrointestinal Woes
2. Gene Variant Raises Risk of Uterine Fibroids
3. Gene Variant Tied to Severity of Drinking
4. Gene Variant Raises Risk for Brain Cancer at Young Age
5. Gene Variant May Hike Womens Risk of Alzheimers
6. Biologist finds plant polymerases IV and V are really variants of Polymerase II
7. Gene Variant Tied to Smokers Risk of Lung Cancer
8. Genetic Variants Tied to Obesity
9. NEW Line of Pushbutton Pill Cases Launched by Variant Products
10. Newly found gene variants account for kidney diseases among African-Americans
11. Genetic variants associated with vitamin B12
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Tied to Cocaine-Induced Paranoia
(Date:6/27/2016)... ... 2016 , ... TherapySites, the leading website and ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to extend ... exclusive benefits and promotional offers. , "TCA is extremely excited about this new ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
Breaking Medicine Technology: