Navigation Links
Gene Variant Tied to Smokers' Risk of Lung Cancer
Date:12/22/2008

2 transporters normally help protect lungs by removing inhaled toxins, study say

MONDAY, Dec. 22 (HealthDay News) -- People may face an increased risk of lung cancer if they have a gene variant that metabolizes the most potent of cigarette smoke carcinogens, a new study says.

The ABCB1 and ABCC1 genes normally help protect the lungs by removing inhaled toxins. Specifically, they act on tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) -- a cigarette smoke component shown to cause lung cancer in rodents.

Researchers at Fudan University in Shanghai, China, recently identified common variants in the ABCB1 and ABCC1 genes (ABCB1 rs3842 or ABCC1 rs212090) tied to people with lung cancer that might indicate a person's increased risk of developing the disease. In particular, women and people under age 60 with ABCB1 rs3842 showed an increased risk of cancer. The variant was also linked to adenocarcinoma, a major type of lung cancer.

"Because tobacco smoking is the leading preventable cause of cancer and the cancer-prone genotypes of these genetic components are relatively prevalent in the human population, our findings have important implications for the prevention of tobacco smoking-related cancers," the study authors wrote.

The findings were published online Dec. 22 in Cancer and will appear in the Feb. 1, 2009, print issue of the journal.

More information

The U.S. National Cancer Institute has more about lung cancer.



-- Kevin McKeever



SOURCE: American Cancer Society, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Genetic Variants Tied to Obesity
2. NEW Line of Pushbutton Pill Cases Launched by Variant Products
3. Newly found gene variants account for kidney diseases among African-Americans
4. Genetic variants associated with vitamin B12
5. APA resolves to play leading role in improving treatment for gender-variant people
6. Gene Variant May Contribute to Alzheimers Disease
7. Gene variants linked to metabolic syndrome and HDL cholesterol levels
8. Common Genetic Variant Tied to Lung Cancer Risk
9. Gene Variant Boosts Risk of Severe Diabetic Eye, Kidney Diseases
10. Gene Variant Boosts Risk for Stress-Related Ischemia
11. Gene Variant Protects Black Heart Failure Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Tied to  Smokers' Risk of Lung Cancer
(Date:9/17/2014)... Tampa, FL (PRWEB) September 17, 2014 Tina ... ), is finishing up her chemotherapy but not her fight ... up for the Komen Florida Suncoast “Race for the Cure” ... “I registered for the Komen Race for the Cure because ... breast cancer,” Griffin said. , As part of her efforts, ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Four ... eighth annual Wailea Tennis Fantasy Camp on ... Maui’s prestigious Wailea Tennis Club, with three-time grand slam ... returning to Wailea, Maui for her fifth year. , ... match play with Davenport, recently inducted into the International ...
(Date:9/17/2014)... September 17, 2014 A raucous childhood ... come together to form author Nancy Chovancek’s laughter-filled new ... is a collection of short stories that prove the ... fun. With a positive message of empowerment and resilience, ... is a proven author with two books under her ...
(Date:9/17/2014)... This September 18-20, 22 participating developmentally-disabled athletes ... three stage outdoor sporting event in non-profit World T.E.A.M. ... , Hosted at The Center for Discovery ... five participating teams coached by able-bodied athletes. For each ... provide expert guidance as well as technical assistance. Like ...
(Date:9/17/2014)... GA (PRWEB) September 17, 2014 Lee ... settlement industry, will be appearing on The Balancing Act® ... two September episodes. , The segment will premiere on ... on 'The Balancing Act® airing on Lifetime Television®' with ... of Asset Funding Corp. for over a decade and ...
Breaking Medicine News(10 mins):Health News:Tina Griffin’s Fight Against Cancer Didn’t Stop With her Chemotherapy—Her Next Step Is to Run in the Suncoast ‘Race for the Cure’ Oct. 11 2Health News:Four Seasons Resort Maui at Wailea Announces 8th Annual Wailea Tennis Fantasy Camp 2Health News:Four Seasons Resort Maui at Wailea Announces 8th Annual Wailea Tennis Fantasy Camp 3Health News:World T.E.A.M. Sports’ Adventure Team Challenge New York Includes Disabled Athletes 2Health News:World T.E.A.M. Sports’ Adventure Team Challenge New York Includes Disabled Athletes 3Health News:Lee Berman Will Appear On The Balancing Act® airing on Lifetime Television® 2
... they sometimes use to compensate for the turbulence of ... They create an artificial star called a guide star ... turbulence. Lihong Wang, PhD, the Gene K. ... in St. Louis, has invented a guide star for ...
... Men looking for Valentine,s Day gifts are most concerned with ... that often means jewelry, according to a shopping behavior expert. ... they do -- and men want reassurance that their taste ... professor of hospitality management at the University of New Hampshire, ...
... SAN FRANCISCO (February 11, 2011) In a study ... Medicine,s (SMFM) annual meeting, The Pregnancy Meeting , in ... despite fetal pulmonary maturity, babies delivered at between 36 ... of neonatal morbidities. The American College of ...
... By E.J. Mundell HealthDay Reporter , THURSDAY, Feb. ... in scarlet, while Today show host Ann Curry ... show host Gayle King, sashayed in a cherry Donna Karan ... Taking part Wednesday night in the annual Red Dress Collection ...
... idea of image compression in computers. File extensions like ".jpg" or ... a more efficient format, reducing file size by a factor of ... quality. The full set of original pixel values would occupy too ... across networks. The brain is faced with a similar problem. ...
... developed by Dr Roger Bayston in the School of Clinical ... awarded an allied health professional training fellowship of almost 160,000 ... prevent bacterial infections associated with broken bones. Pins ... Up to 40 per cent of patients being treated in ...
Cached Medicine News:Health News:A guide star lets scientists see deep into human tissue 2Health News:A guide star lets scientists see deep into human tissue 3Health News:A guide star lets scientists see deep into human tissue 4Health News:A guide star lets scientists see deep into human tissue 5Health News:A guide star lets scientists see deep into human tissue 6Health News:Study finds even with fetal lung maturity, babies delivered prior to 39 weeks are at risk 2Health News:Stars Strut on the Runway for Women's Heart Health 2Health News:Stars Strut on the Runway for Women's Heart Health 3Health News:JPEG for the mind: How the brain compresses visual information 2Health News:Anti-bacterial collar to help mend broken bones 2
(Date:9/16/2014)... SAN DIEGO , Sept. 16, 2014 /PRNewswire/ ... acquired enzastaurin, a late-stage oncology drug, from Eli ... rights to develop, manufacture and commercialize enzastaurin globally, ... rights, data, and information. Lilly ... in Phase 2 and Phase 3 clinical trials ...
(Date:9/16/2014)...  Decision Resources Group finds that the rheumatoid arthritis (RA) disease-modifying ... over $18.2 billion in 2023 in the United States ... , Italy , Spain , ... . TNF-alpha inhibitors will remain the leading drug class in ... will be constrained and patient shares will decline due to the ...
(Date:9/16/2014)... , Sept. 16, 2014   HemCon Medical ... of TriStar Wellness Solutions(R), Inc. (OTCQB: ... advanced medical products, announced today that the revenue ... by 39 percent, and microdispersed oxidized cellulose raw ... 2014.  Overall, TWSI expects third quarter revenues to ...
Breaking Medicine Technology:Denovo Biopharma Acquires Late-Stage Oncology Drug From lilly For Development As A Personalized Medicine 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 3HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 2HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 3HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 4
... April 26 Micromet, Inc. (Nasdaq: MITI ), a biopharmaceutical ... treatment of cancer, today announced that it will host a conference call ... Wednesday, May 5, 2010 , at 8:30 AM ET . , ... To participate in the conference ...
... , April 26 Cornerstone Therapeutics Inc. (Nasdaq: ... developing and commercializing significant products primarily for the respiratory and ... call at 8:00 AM ET on Tuesday, ... the quarter ended March 31, 2010 .  Management will ...
Cached Medicine Technology:Micromet to Report First Quarter 2010 Financial Results on May 5 2Cornerstone Therapeutics to Host First Quarter 2010 Conference Call 2Cornerstone Therapeutics to Host First Quarter 2010 Conference Call 3
... Distriman is a ... that is designed to ... used with Gilson DistriTip ... polypropylene syringes with level ...
... lightweight and balanced for smooth, one-handed control. ... comfort, reducing fatigue in even the longest ... physician to easily steer the catheter through ... one finger. Reflexion's auto-lock technology keeps the ...
... performance technologies - Quantum™ LEAP® balloon ... - unite in the Quantum™ Maverick® ... dilatation force balloon with exceptional deliverability. ... Maverick® shaft technology improves trackability and ...
... Libert Coronary Stent System ... of lesion access and ... a low crossing profile, ... catheter, the performance of ...
Medicine Products: