Navigation Links
Gene Variant Tied to Smokers' Risk of Lung Cancer
Date:12/22/2008

2 transporters normally help protect lungs by removing inhaled toxins, study say

MONDAY, Dec. 22 (HealthDay News) -- People may face an increased risk of lung cancer if they have a gene variant that metabolizes the most potent of cigarette smoke carcinogens, a new study says.

The ABCB1 and ABCC1 genes normally help protect the lungs by removing inhaled toxins. Specifically, they act on tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) -- a cigarette smoke component shown to cause lung cancer in rodents.

Researchers at Fudan University in Shanghai, China, recently identified common variants in the ABCB1 and ABCC1 genes (ABCB1 rs3842 or ABCC1 rs212090) tied to people with lung cancer that might indicate a person's increased risk of developing the disease. In particular, women and people under age 60 with ABCB1 rs3842 showed an increased risk of cancer. The variant was also linked to adenocarcinoma, a major type of lung cancer.

"Because tobacco smoking is the leading preventable cause of cancer and the cancer-prone genotypes of these genetic components are relatively prevalent in the human population, our findings have important implications for the prevention of tobacco smoking-related cancers," the study authors wrote.

The findings were published online Dec. 22 in Cancer and will appear in the Feb. 1, 2009, print issue of the journal.

More information

The U.S. National Cancer Institute has more about lung cancer.



-- Kevin McKeever



SOURCE: American Cancer Society, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Genetic Variants Tied to Obesity
2. NEW Line of Pushbutton Pill Cases Launched by Variant Products
3. Newly found gene variants account for kidney diseases among African-Americans
4. Genetic variants associated with vitamin B12
5. APA resolves to play leading role in improving treatment for gender-variant people
6. Gene Variant May Contribute to Alzheimers Disease
7. Gene variants linked to metabolic syndrome and HDL cholesterol levels
8. Common Genetic Variant Tied to Lung Cancer Risk
9. Gene Variant Boosts Risk of Severe Diabetic Eye, Kidney Diseases
10. Gene Variant Boosts Risk for Stress-Related Ischemia
11. Gene Variant Protects Black Heart Failure Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Tied to  Smokers' Risk of Lung Cancer
(Date:9/25/2017)... ... September 25, 2017 , ... International Water Advocate ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ... focus from a once-every-four-years series of events to a personal, daily Health Olympics. ...
(Date:9/25/2017)... ... , ... Bobbie Horowitz was hardly able to walk without excruciating pain in ... and theater producer, Horowitz would manage to get to rehearsals on time, but wasn’t ... so she had to take a cab everywhere. , It wasn’t until she ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... technology-enabled services supporting clinical research, today announces that 30 of its domain ... the drug development lifecycle at upcoming industry conferences and webinars. Drawing on ...
(Date:9/25/2017)... ... September 25, 2017 , ... Physician Partners of America announces that Chad Gorman, ... as an interventional pain management specialist. , Dr. Gorman is a board-certified physician ... private practice In Brooksville, Fla. His orthopedic background puts him in a unique position ...
(Date:9/25/2017)... New York (PRWEB) , ... September 25, 2017 ... ... Laser & Microsurgery Institute is excited to announce the next generation for LASIK ... Contoura is one of the most technologically advanced laser systems available in the ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... 2017  Eli Lilly and Company (NYSE: ... data for lasmiditan, an investigational, oral, first-in-class molecule for ... improvements compared to placebo in the Phase 3 SPARTAN ... 18th Congress of the International Headache Society (IHC) in ... presented today demonstrate lasmiditan,s potential to reduce pain and ...
(Date:9/7/2017)... NuvoAir (formerly called Pond Healthcare Innovation), ... partnership with Novartis Pharma AG to distribute NuvoAir,s spirometry technology ... leading mobile spirometry platform and Novartis, commitment to address the ... ... ...
(Date:9/6/2017)... Sept. 6, 2017  Medical professionals are ... skills while treating their patients. Medical simulations ... without involving patients. Simulation provides a safe ... carry out procedures, refine techniques and build ... of new technology, such as augmented reality, ...
Breaking Medicine Technology: