Navigation Links
Gene Variant Tied to Smokers' Risk of Lung Cancer
Date:12/22/2008

2 transporters normally help protect lungs by removing inhaled toxins, study say

MONDAY, Dec. 22 (HealthDay News) -- People may face an increased risk of lung cancer if they have a gene variant that metabolizes the most potent of cigarette smoke carcinogens, a new study says.

The ABCB1 and ABCC1 genes normally help protect the lungs by removing inhaled toxins. Specifically, they act on tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) -- a cigarette smoke component shown to cause lung cancer in rodents.

Researchers at Fudan University in Shanghai, China, recently identified common variants in the ABCB1 and ABCC1 genes (ABCB1 rs3842 or ABCC1 rs212090) tied to people with lung cancer that might indicate a person's increased risk of developing the disease. In particular, women and people under age 60 with ABCB1 rs3842 showed an increased risk of cancer. The variant was also linked to adenocarcinoma, a major type of lung cancer.

"Because tobacco smoking is the leading preventable cause of cancer and the cancer-prone genotypes of these genetic components are relatively prevalent in the human population, our findings have important implications for the prevention of tobacco smoking-related cancers," the study authors wrote.

The findings were published online Dec. 22 in Cancer and will appear in the Feb. 1, 2009, print issue of the journal.

More information

The U.S. National Cancer Institute has more about lung cancer.



-- Kevin McKeever



SOURCE: American Cancer Society, news release, Dec. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Genetic Variants Tied to Obesity
2. NEW Line of Pushbutton Pill Cases Launched by Variant Products
3. Newly found gene variants account for kidney diseases among African-Americans
4. Genetic variants associated with vitamin B12
5. APA resolves to play leading role in improving treatment for gender-variant people
6. Gene Variant May Contribute to Alzheimers Disease
7. Gene variants linked to metabolic syndrome and HDL cholesterol levels
8. Common Genetic Variant Tied to Lung Cancer Risk
9. Gene Variant Boosts Risk of Severe Diabetic Eye, Kidney Diseases
10. Gene Variant Boosts Risk for Stress-Related Ischemia
11. Gene Variant Protects Black Heart Failure Patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Tied to  Smokers' Risk of Lung Cancer
(Date:2/17/2017)... , ... February 17, 2017 , ... ... that allow for the electronic prescribing of controlled and non-controlled substances plus the ... percent of pharmacies in the United States now accept electronic prescriptions, according to ...
(Date:2/17/2017)... ... February 17, 2017 , ... Empowering each person's mental ... for each and every seminar, session and class she offers. At the ... tools which help energize creativity, focus mental functions, enhance athletic focus and skill ...
(Date:2/17/2017)... ... February 17, 2017 , ... Access today ... Exhibition in Orlando, Fla., February 19-23. Visitors to the company’s booth (#1778) will ... used electronic patient signatures solution in healthcare . , Since it first ...
(Date:2/17/2017)... Miami, F.L. (PRWEB) , ... February 17, 2017 ... ... geared to clinical operations executives and focusing on all facets of clinical trial ... portfolio management , patient engagement, and more. In addition, attendees stopping by ...
(Date:2/17/2017)... ... ... Like most hospitals across the nation, Onslow Memorial Hospital is looking for ... Reduction Program (HRRP), the return of a patient to the hospital within 30 days ... many providers are struggling to leverage limited resources and technology, Onslow Memorial Hospital has ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... 16, 2017 Quest Diagnostics (NYSE: ... services, today announced that it has been named one ... Fortune. The annual survey designated Quest ... "Health Care: Pharmacy and Other Services" industry to attain ... company to attain the designation. This is the second ...
(Date:2/16/2017)... The global preparative and process chromatography market ... from USD 5.49 billion in 2016, at a CAGR ... type, the preparative and process chromatography market is segmented ... process chromatography segment is expected to account for the ... Growth in this segment can primarily be attributed to ...
(Date:2/16/2017)... Conn. , Feb. 16, 2017 The Lockwood ... the 2017 Best Place to Work in Connecticut ... This is the third year in a row that Lockwood ... this year to earn the number-two spot in 2017. The ... maintaining workplace excellence. The winners were determined through a survey ...
Breaking Medicine Technology: