Navigation Links
Gene Variant Seems to Guard Against Asthma, COPD
Date:12/16/2009

. Juan C. Celedon, an associate professor of medicine at Brigham and Women's Hospital and Harvard Medical School in Boston and his colleagues looked at seven different groups of people, in all comprising 8,300 children and adults.

A variant of MMP12 was associated with better lung function in children with asthma.

In adults, the variant led to better lung function in adult smokers and reduced the risk of COPD in former or current smokers.

The findings, published online Dec. 16 in the New England Journal of Medicine, also shed new light on the connections between asthma and COPD.

"This suggests that there are some genes that may influence both asthma and COPD, so that for a subgroup of people there may be common determinants," said study senior author Celedon.

"There is certainly overlapping in that how you get asthma and how you get COPD is related and probably very closely related," Cirillo said. "That's exciting because it suggests that if we can decrease or increase expression of genes that are common to both, we could potentially affect both. It's nice to have one treatment."

All of which makes sense, Edelman said. "This gene is involved in the inflammatory process, and asthma is a disease of inflammation and COPD is a disease of inflammation," he noted. "The results are different and the pathways are different but you're still talking about inflammation of the lung. It's not terribly surprising that it appears to be protective in both circumstances."

More information

The American Lung Association has more on lung disease.



SOURCES: Juan C. Celedon, M.D., Dr.P.H., associate professor, medicine, Brigham and Women's Hospital and Harvard Medical School, Boston; Norman Edelman, M.D., chief medical officer, American Lung Association; Jeffrey Cirillo, Ph.D., professor, mic
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Five Gene Variants May Be Linked to Lung Disease
2. Genetic Variant Slows AIDS Progression
3. Gene Variants Behind Vulnerability to Yeast Infections
4. Clues to visual variant Alzheimers; myopia and diabetic retinopathy risk
5. Glaucoma Tied to Gene Variants in Blacks
6. Trio of Gene Variants Discovered That May Raise Alzheimers Risk
7. Variants of umami taste receptor contribute to our individualized flavor worlds
8. International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
9. Worlds largest DNA scan for autism uncovers new gene variant for disorder
10. MCG participating in national study to identify genetic variants in schizophrenia
11. Genetic variants predict recurrence of bladder cancer, patient survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The City of West Hollywood hosted a news conference on Thursday, ... of the Supreme Court decision Roe v. Wade, which legalized abortion ... Roe vs. Wade decision and the fight to protect a women’s ... of West Hollywood Councilmember Abbe Land. “We need to continue to ...
(Date:1/22/2015)... 22, 2015 Padre Murphy's and Owner Tom ... Pro Player Health Alliance (PPHA). The PPHA's passion ... getting everyone, including NFL greats, treated for obstructive sleep apnea ... groups supporting the cause in the valley. The most recent ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company offering many ... it on Facebook, Twitter, and Pinterest. The fans will have ... a lottery every week. , Moreover, the company has extended ... Angelweddingdress homepage for more information. , Angelweddingdress ...
(Date:1/22/2015)... 22, 2015 The federal court overseeing thousands ... District Court, Southern District of West Virginia has upheld a ... proceeding’s first bellwether trial. In an Order dated January 21st, ... after finding that C.R. Bard had not proven a miscarriage ...
(Date:1/22/2015)... York, New York (PRWEB) January 22, 2015 ... filed after Fresenius Medical Care recalled its GranuFlo and ... federal multidistrict litigation underway in U.S. District Court, District ... Order dated January 20th, the Court has remanded a ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4
... in Higher Education (AGHE) the educational branch of ... its 37th Annual Meeting and Educational Leadership Conference ... Netherland Plaza in Cincinnati, OH. Media representatives are ... provides a forum for professionals in the field of aging ...
... , THURSDAY, Feb. 24 (HealthDay News) -- Fewer ... antigen (PSA) screening for prostate cancer since the release of ... a few years ago, say researchers. This study examined ... the decline in PSA screening was three percent among men ...
... - New findings by a University of Maryland-led team ... genes for a human anti-malarial antibody or a ... and environmentally friendly tool for combating malaria, at a ... mosquitoes is declining. In a study published in ...
... DC -- The U.S. Food and Drug Administration and ... partnership to stimulate innovation in regulatory science, ethics, education, ... institutions to meet their common goal of improving public ... and the unique opportunities for supporting our goal of ...
... THURSDAY, Feb. 24 (HealthDay News) -- Preliminary research suggests that ... stave off progression of the AIDS-causing virus. Although it,s ... findings of this small study raise the possibility that "there ... in HIV patients whether they,re taking AIDS medications or not," ...
... of the nation,s donor-liver distribution network developed by University ... people each year receiving the transplants they need. ... Science that donor livers currently are doled out ... for geography and demographics, an arrangement that prevents many ...
Cached Medicine News:Health News:As America's senior population grows, meeting to outline effective education about aging 2Health News:PSA Screening for Prostate Cancer Dips in Large U.S. Health Network 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 2Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 3Health News:New study shows ability of transgenic fungi to combat malaria and other bug-borne diseases 4Health News:FDA and Georgetown University Medical Center announce partnership 2Health News:Statins Might Help HIV Patients, Study Suggests 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 2Health News:Redesign of US donor-liver network could boost transplants by several hundred per year 3
(Date:1/22/2015)... Inc. (NASDAQ: UPI ), a medical device company ... treat voiding dysfunctions, today reported financial results for the ... Global revenue for the Company,s Urgent ®  PC Neuromodulation ... revenue record, as compared to $3.9 million in the ...
(Date:1/22/2015)... (NASDAQ: AMGN ) today announced that it will report ... Jan. 27, 2015, after the close of the U.S. financial markets. ... investment community at 2 p.m. PT. Participating in the call from ... executive officer, and other members of Amgen,s senior management team. ...
(Date:1/22/2015)... Increasing sophistication among enterprise buyers of language services ... 2015, says Moravia CMO, Renato Beninatto ... market research firm Common Sense Advisory, 15 percent of ... and localization needs. "From a language industry perspective, this ...
Breaking Medicine Technology:Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... 2010 Despite national guidelines recommending that ... treatment for patients with mild persistent asthma, a new ... taking more costly drugs that combine an ICS and ... additional clinical benefit noted based on pharmacy and medical ...
... Corporation ("Unilife" or "Company") (Nasdaq: UNIS ; ASX: ... its Unitract® range of 1mL safety syringes. ... largest medical supply co-operatives in the U.S., have entered into ... 1mL syringes to U.S. healthcare facilities. IMCO,s ...
Cached Medicine Technology:New Study: Overuse of Combination Drug Therapy in Patients with Mild Asthma Leads to Increased Costs 2New Study: Overuse of Combination Drug Therapy in Patients with Mild Asthma Leads to Increased Costs 3New Study: Overuse of Combination Drug Therapy in Patients with Mild Asthma Leads to Increased Costs 4Unilife Commences U.S. Sales of Unitract® 1mL Syringes 2Unilife Commences U.S. Sales of Unitract® 1mL Syringes 3Unilife Commences U.S. Sales of Unitract® 1mL Syringes 4
... The RCAI Bariatric Knee Immobilizer is ... lateral stays with a breathable foam material ... , ,The posterior aspect of the ... custom anatomical fit. The loop and lock ...
... breathable foam. Three piece design for precise ... loop closures. Lightweight rigid posterior stays with ... with optional hot and cold therapy Gel ... pain cycle by providing cold therapy to ...
... Neuroprene™ soft supports are a ... to proprioceptive taping for common orthopedic ... help provide specific compression and lateral ... receptors (proprioceptors) in the skin and ...
... UltraWrap™ is a low-profile, wraparound, hinged ... Ideal for patients who have difficulty ... contouring pull points for ease of application. ... correctly fit and easily secure the anterior ...
Medicine Products: