Navigation Links
Gene Variant Seems to Guard Against Asthma, COPD
Date:12/16/2009

Study suggests it plays a role in reducing inflammation in the lungs

WEDNESDAY, Dec. 16 (HealthDay News) -- A gene variant that plays a role in inflammation seems to protect the lungs of children with asthma as well as adults who smoke.

Researchers also found that adult smokers with this variant of the MMP12 gene had a lower risk of developing chronic obstructive pulmonary disease (COPD), a progressive condition often brought on by smoking.

"The gene seems to be protective of the lungs in both asthma and COPD," said Dr. Norman Edelman, chief medical officer of the American Lung Association.

Any new gene identified raises the hope that it will provide ways to prevent or treat the disease to which it is allied and this is no exception.

"Levels of the MMP12 gene may impact the quality of life for those individuals with asthma and COPD, and may allow us to come up with potential therapeutic approaches," added Jeffrey Cirillo, professor of microbial and molecular pathogenesis at Texas A&M Health Science Center College of Medicine in College Station. "By understanding more about this specific gene we can find ways to induce or oppress that protein expression in the lungs."

"The real question is not why people who smoke get COPD. We kind of know the answer to that. The question is why do people who don't smoke get COPD," added Edelman. "If we understood that, we could find ways to reverse it and protect people."

The MMP12 gene has been implicated in the development of emphysema in mice that are exposed to smoke, suggesting that the gene may also be important in the onset of emphysema in humans. The gene is also linked with other genes involved in asthma.

This information, combined with the fact that factors that can cause the onset of asthma in children are also involved with how well your lungs function in adulthood spurred investigators to undertake this study.

Dr. Juan C. Celedon, an associate professor of medicine at Brigham and Women's Hospital and Harvard Medical School in Boston and his colleagues looked at seven different groups of people, in all comprising 8,300 children and adults.

A variant of MMP12 was associated with better lung function in children with asthma.

In adults, the variant led to better lung function in adult smokers and reduced the risk of COPD in former or current smokers.

The findings, published online Dec. 16 in the New England Journal of Medicine, also shed new light on the connections between asthma and COPD.

"This suggests that there are some genes that may influence both asthma and COPD, so that for a subgroup of people there may be common determinants," said study senior author Celedon.

"There is certainly overlapping in that how you get asthma and how you get COPD is related and probably very closely related," Cirillo said. "That's exciting because it suggests that if we can decrease or increase expression of genes that are common to both, we could potentially affect both. It's nice to have one treatment."

All of which makes sense, Edelman said. "This gene is involved in the inflammatory process, and asthma is a disease of inflammation and COPD is a disease of inflammation," he noted. "The results are different and the pathways are different but you're still talking about inflammation of the lung. It's not terribly surprising that it appears to be protective in both circumstances."

More information

The American Lung Association has more on lung disease.



SOURCES: Juan C. Celedon, M.D., Dr.P.H., associate professor, medicine, Brigham and Women's Hospital and Harvard Medical School, Boston; Norman Edelman, M.D., chief medical officer, American Lung Association; Jeffrey Cirillo, Ph.D., professor, microbial and molecular pathogenesis, Texas A&M Health Science Center College of Medicine, College Station, Texas; Dec. 16, 2009, New England Journal of Medicine


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Five Gene Variants May Be Linked to Lung Disease
2. Genetic Variant Slows AIDS Progression
3. Gene Variants Behind Vulnerability to Yeast Infections
4. Clues to visual variant Alzheimers; myopia and diabetic retinopathy risk
5. Glaucoma Tied to Gene Variants in Blacks
6. Trio of Gene Variants Discovered That May Raise Alzheimers Risk
7. Variants of umami taste receptor contribute to our individualized flavor worlds
8. International Collaboration led by Dr. Pablo V. Gejman,Researcher At NorthShore University HealthSystem's Research Institute, Finds Genetic Association of Schizophrenia to Chromosome 6p Variant
9. Worlds largest DNA scan for autism uncovers new gene variant for disorder
10. MCG participating in national study to identify genetic variants in schizophrenia
11. Genetic variants predict recurrence of bladder cancer, patient survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many ... event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids ... of all ages; it is a non-competitive, non-timed event, which is all about having ...
(Date:10/13/2017)... ... 13, 2017 , ... “America On The Brink”: the Christian history of the ... is the creation of published author, William Nowers. Captain Nowers and his wife, ... he spent thirty years in the Navy. Following his career as a naval ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... of $3,296 in property taxes a year. In some states—like New York, New ... , By contrast, many overseas retirement havens have extremely low property-tax rates, which ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... --  OrthoAtlanta has been named the official orthopedic and ... for the 2018 College Football Playoff (CFP) National Championship to ... in Atlanta, Georgia . OrthoAtlanta is proud ... participating in many activities leading up to, and including the ... ...
(Date:9/12/2017)... 12, 2017  Consumer reviews on the independent review site ... number one company for hearing aids, ranking it higher than ... ... by Consumers For Hearing Aids ... is an online store that provides high performance, state-of-the-art, German-engineered hearing ...
(Date:9/9/2017)... ... ... Monday, September 18 th .The Brain Tumor Foundation (BTF) begins a week-long ... BTF,s Mobile MRI Unit – a 70 Ft. ... brings its nationwide initiative, the Road to Early Detection Sponsor-A-City Campaign to ...
Breaking Medicine Technology: