Navigation Links
Gene Variant May Raise Death Risk After Heart Bypass
Date:9/17/2011

FRIDAY, Sept. 16 (HealthDay News) -- People who carry a certain genetic variant involved in blood clotting and inflammation have a lower five-year survival rate after coronary artery bypass surgery, researchers report.

The findings should be used to better treat and ensure the survival of these surgical patients over the long-term, said the research team from Duke University Medical Center in Durham, N.C.

"There are possibilities that we could apply this information someday to a patient's prognosis, and for careful monitoring or increased surveillance if a person has a 2.5 times higher risk of dying, instead of letting them go their way after a CABG [coronary artery bypass graft] surgery," study senior author Mihai Podgoreanu, an assistant professor of anesthesiology, said in a Duke news release.

In conducting the study, published in the Sept. 12 issue of Circulation, the researchers found variants in the thrombomodulin gene were associated with greater risk of death in the five years following CABG surgery in a group of roughly 1,000 patients.

The researchers also took other known risk factors into consideration and confirmed their findings by repeating the study with a separate group of about 1,000 more patients.

"In any biomarker association study, current wisdom is that there are a lot of false positive findings, so we used specimens from a different, independent cohort of patients to increase our confidence that the initial results were not spurious," said Podgoreanu.

The authors concluded that although more research is needed to determine exactly how the findings will benefit the long-term survival of individual heart surgery patients, knowing whether or not a patient has this gene variant will help doctors better assess patient risks.

More information

The U.S. National Institutes of Health provides more information on coronary bypass surgery.

-- Mary Elizabeth Dallas

SOURCE: Duke Medicine, news release, Sept. 13, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Six new genetic variants linked to type 2 diabetes discovered in South Asians
2. Gene Variants That Boost Lung Cancer Risk Identified
3. Scientists show how gene variant linked to ADHD could operate
4. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
5. Gene Variant Associated With Asthma Risk in Blacks
6. Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
7. Gene Variant May Be Linked to Deadly Lung Fibrosis
8. Spotting Gene Variants May Boost Hepatitis C Treatment
9. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
10. Mayo-led researchers discover genetic variants modifying breast cancer risk
11. Scientists Spot Gene Variants That Predict Longevity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant May Raise Death Risk After Heart Bypass
(Date:4/28/2016)... D.C. (PRWEB) , ... April 28, 2016 , ... The ... and Prevention (CDC) has established an ICD-10-CM code for sarcopenia, giving it recognition for ... the medical community effective October 1, 2016. , Sarcopenia is defined as a combination ...
(Date:4/28/2016)... Hollywood, CA (PRWEB) , ... April 28, 2016 , ... ... emergency dental care as soon as possible is essential when it comes to dental ... may make the difference between saving and losing a tooth. Toothaches, knocked-out teeth, chipped ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... health insurance co-operative bankruptcy to receive their prescription medications through America’s fastest-growing ... FDA-approved prescription medications from over 180 American pharmaceutical companies for $35 per ...
(Date:4/28/2016)... ... 2016 , ... For many, a diet is only as good as it looks. No matter ... good. In addition, an individual cannot deny the importance of maintaining a healthy diet and ... worked to create a product range that could entice people to eat clean and enjoy ...
(Date:4/28/2016)... ... April 28, 2016 , ... Today Nimblify, Inc. ... Calendar Exchange , is officially open to all sponsors in the industry. The ... to download into their clinical trial management system (CTMS), which is the site’s ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016  Marking its one year anniversary since ... cancer risk test, Color Genomics announced ... highly impact the most common hereditary cancers affecting ... Test analyzes hereditary cancer risks for breast, colorectal, ... The Color Test is physician ordered and includes ...
(Date:4/28/2016)... 2016 Treato , the ... announced today that it has been named a Cool ... in Life Sciences, 2016, Stephen Davies , ... focuses on life-science- oriented analytics, algorithms and smart machine ... doctors, confirm medication ingestion, and analyze unstructured information.   ...
(Date:4/28/2016)... , April 28, 2016 Oramed Pharmaceuticals ... clinical-stage pharmaceutical company focused on the development of oral drug ... the upcoming PIONEERS 2016 conference, presented by Joseph Gunnar ... in New York . Nadav Kidron ... the conference. Presentation Details:   ...
Breaking Medicine Technology: