Navigation Links
Gene Variant May Be Linked to Deadly Lung Fibrosis
Date:4/20/2011

By Jenifer Goodwin
HealthDay Reporter

WEDNESDAY, April 20 (HealthDay News) -- Researchers have identified a genetic variant that's found in at least 59 percent of those who have pulmonary fibrosis, a deadly lung disease that typically kills within a few years of diagnosis.

Those with the gene variant had nearly 7 to 22 times the risk of contracting the lethal disease.

For the study, the researchers did a genome-wide linkage scan of 82 families with pulmonary fibrosis of an unknown cause. This type of scan typically looks at how inheritance patterns of multiple affected families are related to several hundred markers throughout the DNA.

The researchers zeroed in on chromosome 11, where they found a common gene variant.

The researchers then compared the results to the genomes of 83 people with familial pulmonary fibrosis (meaning it runs in their family), 492 people with idiopathic pulmonary fibrosis (the type for which there's no known cause) and 322 people without lung disease.

More genetic mapping showed that about 59 percent of people who have familial pulmonary fibrosis (also known as familial interstitial pneumonia) and 67 percent of those with the idiopathic type had the particular variant, or polymorphism.

Only 18 percent of those who did not have lung disease had that variant.

Pulmonary fibrosis involves rapid and progressive scarring of the lungs, making it increasingly difficult to breathe. It develops mostly in middle-age and older adults, according to the Coalition for Pulmonary Fibrosis. Each year, about 40,000 people in the United States die of the disease.

"This gene variant contributes to the development of disease in 60 percent of patients with pulmonary fibrosis," said the study's senior author, Dr. David Schwartz, chairman of the department of medicine at the University of Colorado and director of the Center for Genes, Environment & Health at National Jewish
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4

Related medicine news :

1. First Gene Variants Linked to Stuttering Discovered
2. Gene Variant May Help Some Overcome Adversity
3. Genetic Variant Raises Lung Cancer Risk
4. Genetic variant greatly increases lung cancer risk for light smokers
5. Gene Variant May Raise Risk of Common Eye Disease
6. Genetic Variants Tied to MS, Study Finds
7. Success of Hepatitis C Drugs May Depend on Gene Variant
8. Scientists Spot Gene Variants That Predict Longevity
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Spotting Gene Variants May Boost Hepatitis C Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant May Be Linked to Deadly Lung Fibrosis
(Date:8/31/2014)... August 31, 2014 “Prohibition is ... (empiricism) is our future: the present ~ that’s ... Cannabinoid Science , new on the Bryan William ... on cannabinoid system (CS) modulation and homeostasis - ... chronic alcohol use. The Publius CS update includes: ...
(Date:8/31/2014)... 2014 Future Health, a market-leading ... firm that focuses on helping doctors utilize technology ... congruent commitment with the creators of education based ... create an environment that assists doctors to operate ... with patients,” says Steven Kraus, founder and CEO ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 Brook ... award winning, “Simplicity & Sophistication: Short Stories of ... and narrated by Dr. James W. Jackson author, speaker, ... Dr. Jackson compresses his vast volume of ... decades into over 150 countries on behalf of ...
(Date:8/31/2014)... The severity of menopausal symptoms will ... menopause is expert in helping patients find the ... uncomfortable symptoms with the latest treatment options, including hormone ... variety of alternative treatments and products that can relieve ... may fall outside of what can be called conventional ...
(Date:8/31/2014)... Barcelona, Spain Sunday 31 August 2014: Mortality ... at one year despite good use of oral anticoagulants, ... Atrial Fibrillation General Pilot Registry. The findings were presented ... by registry chairperson Professor Gregory Lip (Birmingham, UK). , ... sponsored registry focused on management practices of European cardiologists ...
Breaking Medicine News(10 mins):Health News:Homeostasis: Publius’ Alcohol Political Cannabinoid Science ~ New on the Bryan William Brickner Blog 2Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 2Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 3Health News:Powerhouse EHR, Future Health, Announces Gold Sponsorship of POWERPlay in Sports National Tour 4Health News:Brook Forest Voices Announces End of Summer Release! Dr. James Jackson’s, “Simplicity & Sophistication” Audiobook 2Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 2Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 3Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 4Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 5Health News:AF mortality and morbidity high at 1 year despite good anticoagulant use 2
... of Dental Implants with Laser-Lok(R) Technology over Traditional ... in the dental implant industry, reported today that ... of implants with Laser-Lok (R) surface treatment ... vitro and in animal studies. Laser-Lok implants ...
... may drive the connection, researchers say , , TUESDAY, May ... lasting effects not just on her own health but ... , "Children with asthmatic parents are at an increased ... pregnancy," said H.A. Smit, head of the department of ...
... Escalon Medical Corp. (Nasdaq: ESMC ) ... March 31, 2009. For the third quarter of fiscal ... compared with $8,188,000 in the third quarter of fiscal ... third quarter of fiscal 2009, a 12.7% increase, compared ...
... How Executives and Employees are evaluated and paid is ... the Society of Corporate Compliance and Ethics and the ... that they want their employees to do the right ... bad behavior? The Society of Corporate Compliance and ...
... due to taking hormone replacement therapy appears to be the ... and without a family history, a University of Rochester Medical ... in the journal Epidemiology , adds to the evolving ... breast cancer risk among postmenopausal women. It also refutes the ...
... work of Julia Hippisley-Cox, Professor of Clinical Epidemiology and ... recognised by the Royal College of General Practitioners. , ... Fry Silver Medal an award made each year ... promoted the discipline of general practice through research and ...
Cached Medicine News:Health News:BioHorizons Reports on Comparative 3-Year Dental Implant Study Showing Significant Crestal Bone and Soft Tissue Retention Using Laser-Lok(R) Microchannels 2Health News:BioHorizons Reports on Comparative 3-Year Dental Implant Study Showing Significant Crestal Bone and Soft Tissue Retention Using Laser-Lok(R) Microchannels 3Health News:Overweight Moms More Likely to Have Asthmatic Kids 2Health News:Overweight Moms More Likely to Have Asthmatic Kids 3Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 2Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 3Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 4Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 5Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 6Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 7Health News:Escalon(R) Reports Third Quarter Fiscal 2009 Results 8Health News:Executive Compensation Controversy Rages, SCCE to Determine What Role Compliance and Ethics Play 2Health News:HRT-breast cancer risk stays same, regardless of family history 2Health News:Prestigious award for 'outstanding' primary-care researcher 2Health News:Prestigious award for 'outstanding' primary-care researcher 3
(Date:8/29/2014)... Aug. 29, 2014  BC Technical, the nation,s leading ... Medical Imaging, a leader in sales, service and installation ... allows BC Technical to continue to expand their resources ... and CT modalities. "We are committed ... Mark Alvarez , president and CEO of BC Technical. ...
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
(Date:8/29/2014)... WASHINGTON , Aug. 29, 2014 Diseases ... a generation ago are returning. Measles was declared ... cases in 2014 as of August 15—the highest incidence ... public health department declared whooping cough a problem ... children are getting sick and dying from these preventable ...
Breaking Medicine Technology:BC Technical Acquires Polaris Medical Imaging 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3
... M.D., president of SPRI,Clinical Trials, will be a featured ... Group Investor Seminar -- Management,s Guide to,Wall Street. The ... Midtown,Loft & Terrace, 267 Fifth Avenue in New York. ... and small and mid-cap life science companies to gain,better ...
... In the news release, "Update on the SEAS Study" issued ... Principal Investigator & Head,of Steering Committee over PR Newswire, we ... information has been added to the,release:, , Satellite coordinates, ... Satellite: AB1 12.5 Deg West Txp: B6 Lower, ...
Cached Medicine Technology:/C O R R E C T I O N -- Prof Terje Pedersen, SEAS Study Principal Investigator & Head of Steering Committee/ 2/C O R R E C T I O N -- Prof Terje Pedersen, SEAS Study Principal Investigator & Head of Steering Committee/ 3