Navigation Links
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
Date:5/13/2011

FRIDAY, May 13 (HealthDay News) -- A common gene variant among black people may be linked to the development of life-threatening heart arrhythmias (when the heart beats too fast, too slow or irregularly), according to a new study.

In pinpointing this gene, Duke University Medical Center researchers hope to one day help doctors determine which patients are likely to benefit most from an implantable cardio-defibrillator (ICD) -- a device that automatically detects and corrects potentially deadly heart rhythms by delivering a jolt of electricity.

Blacks are disproportionately affected by heart failure, arrhythmias and sudden cardiac death, "but are vastly underrepresented in the majority of clinical trials conducted to date," the study's lead author, Dr. Albert Y. Sun, said in a university news release. "Much debate surrounds the identification of patients for ICD implantation, which takes into account efficacy, cost and complication rates."

The study, published in the current issue of the journal Circulation: Cardiovascular Genetics, included 112 black patients who received ICDs for primary prevention of sudden cardiac death. Over a follow-up period that averaged about two years, ICDs were effectively activated in 23 of the patients.

The investigators found that patients with the gene variant, known as the Y1103 allele, were three times more likely have the device triggered because of a potentially life-threatening ventricular arrhythmia. "These findings are significant because approximately 13 percent of people of African descent carry this variant," Sun noted.

Patients with the gene variant also experienced their first arrhythmia 448 days sooner than those without the gene (609 days versus 1,057 days). "This is the largest genetic study to date of blacks with ICDs and it promises potential new diagnostic strategies to define patients who will most benefit from ICDs," concluded the study's principal investigator, Dr. Geoffrey S. Pitt, director of Duke's Ion Channel Research Unit, in the news release.

More information

The American Heart Association offers detailed information on heart arrhythmias.

-- Mary Elizabeth Dallas

SOURCE: Duke University, news release, May 11, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First Gene Variants Linked to Stuttering Discovered
2. Gene Variant May Help Some Overcome Adversity
3. Genetic Variant Raises Lung Cancer Risk
4. Genetic variant greatly increases lung cancer risk for light smokers
5. Gene Variant May Raise Risk of Common Eye Disease
6. Genetic Variants Tied to MS, Study Finds
7. Success of Hepatitis C Drugs May Depend on Gene Variant
8. Scientists Spot Gene Variants That Predict Longevity
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Spotting Gene Variants May Boost Hepatitis C Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: