Navigation Links
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
Date:5/13/2011

FRIDAY, May 13 (HealthDay News) -- A common gene variant among black people may be linked to the development of life-threatening heart arrhythmias (when the heart beats too fast, too slow or irregularly), according to a new study.

In pinpointing this gene, Duke University Medical Center researchers hope to one day help doctors determine which patients are likely to benefit most from an implantable cardio-defibrillator (ICD) -- a device that automatically detects and corrects potentially deadly heart rhythms by delivering a jolt of electricity.

Blacks are disproportionately affected by heart failure, arrhythmias and sudden cardiac death, "but are vastly underrepresented in the majority of clinical trials conducted to date," the study's lead author, Dr. Albert Y. Sun, said in a university news release. "Much debate surrounds the identification of patients for ICD implantation, which takes into account efficacy, cost and complication rates."

The study, published in the current issue of the journal Circulation: Cardiovascular Genetics, included 112 black patients who received ICDs for primary prevention of sudden cardiac death. Over a follow-up period that averaged about two years, ICDs were effectively activated in 23 of the patients.

The investigators found that patients with the gene variant, known as the Y1103 allele, were three times more likely have the device triggered because of a potentially life-threatening ventricular arrhythmia. "These findings are significant because approximately 13 percent of people of African descent carry this variant," Sun noted.

Patients with the gene variant also experienced their first arrhythmia 448 days sooner than those without the gene (609 days versus 1,057 days). "This is the largest genetic study to date of blacks with ICDs and it promises potential new diagnostic strategies to define patients who will most benefit from ICDs," concluded the study's principal investigator, Dr. Geoffrey S. Pitt, director of Duke's Ion Channel Research Unit, in the news release.

More information

The American Heart Association offers detailed information on heart arrhythmias.

-- Mary Elizabeth Dallas

SOURCE: Duke University, news release, May 11, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First Gene Variants Linked to Stuttering Discovered
2. Gene Variant May Help Some Overcome Adversity
3. Genetic Variant Raises Lung Cancer Risk
4. Genetic variant greatly increases lung cancer risk for light smokers
5. Gene Variant May Raise Risk of Common Eye Disease
6. Genetic Variants Tied to MS, Study Finds
7. Success of Hepatitis C Drugs May Depend on Gene Variant
8. Scientists Spot Gene Variants That Predict Longevity
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Spotting Gene Variants May Boost Hepatitis C Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
(Date:12/5/2016)... ... December 05, 2016 , ... Airy Jeanine is putting ... Songwriter-Producer Corey “Chorus” Gibson who has worked on hits by mega-artists like Rihanna, ... https://twitter.com/coreychorus , The sessions taking place in North Jersey’s Cybertime Studios ...
(Date:12/5/2016)... ... December 05, 2016 , ... As renowned, board-certified dermatologists, Dr. Sabrina G. Fabi ... patients who do not do their research and undergo cosmetic dermatology treatments from unqualified ... midst of a renaissance and every other month a new treatment or device is ...
(Date:12/5/2016)... Columbus, OH (PRWEB) , ... December 05, 2016 ... ... novel engineering solution called the CardioQuick Patch® significantly improves the reproducibility and accuracy ... usability in various healthcare settings. , Over the last 60 years, studies ...
(Date:12/4/2016)... , ... December 03, 2016 , ... While James Earl ... serving as host for in a show called "Front Page". One of the forthcoming ... years, breast cancer rates have plummeted in large part due to early detection. Like ...
(Date:12/4/2016)... ... December 04, 2016 , ... Patients who wish ... take advantage of a cosmetic procedure known as Carbon Dioxide (C02) Fractional ... appearance of age spots, fine lines, uneven coloration, wrinkles, scarring, skin laxity ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec 2, 2016 Research and Markets has ... newsletter to their offering. ... , R&D Drug Pipeline ... proprietary R&D Drug Pipeline Database provides 24/7 online access to information ... the market and on investigational drug candidates in research & development. ...
(Date:12/2/2016)... -- bioLytical Laboratories, un líder mundial en test rápidos de enfermedades ... Test , a los miembros de la Kenya Pharmaceutical Association. ... ... HIV Self Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical fue invitada por la Clinton Health ...
(Date:12/2/2016)... SPRINGFIELD GARDENS, N.Y. , Dec. 2, 2016 /PRNewswire/ ... victims, will be included in the Emergency Response Training ... "We are very excited to have LifeVac become part ... Arthur Lih , Founder and CEO of LifeVac. "Having ... use LifeVac safely and effectively will help leverage our ...
Breaking Medicine Technology: