Navigation Links
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
Date:5/13/2011

FRIDAY, May 13 (HealthDay News) -- A common gene variant among black people may be linked to the development of life-threatening heart arrhythmias (when the heart beats too fast, too slow or irregularly), according to a new study.

In pinpointing this gene, Duke University Medical Center researchers hope to one day help doctors determine which patients are likely to benefit most from an implantable cardio-defibrillator (ICD) -- a device that automatically detects and corrects potentially deadly heart rhythms by delivering a jolt of electricity.

Blacks are disproportionately affected by heart failure, arrhythmias and sudden cardiac death, "but are vastly underrepresented in the majority of clinical trials conducted to date," the study's lead author, Dr. Albert Y. Sun, said in a university news release. "Much debate surrounds the identification of patients for ICD implantation, which takes into account efficacy, cost and complication rates."

The study, published in the current issue of the journal Circulation: Cardiovascular Genetics, included 112 black patients who received ICDs for primary prevention of sudden cardiac death. Over a follow-up period that averaged about two years, ICDs were effectively activated in 23 of the patients.

The investigators found that patients with the gene variant, known as the Y1103 allele, were three times more likely have the device triggered because of a potentially life-threatening ventricular arrhythmia. "These findings are significant because approximately 13 percent of people of African descent carry this variant," Sun noted.

Patients with the gene variant also experienced their first arrhythmia 448 days sooner than those without the gene (609 days versus 1,057 days). "This is the largest genetic study to date of blacks with ICDs and it promises potential new diagnostic strategies to define patients who will most benefit from ICDs," concluded the study's principal investigator, Dr. Geoffrey S. Pitt, director of Duke's Ion Channel Research Unit, in the news release.

More information

The American Heart Association offers detailed information on heart arrhythmias.

-- Mary Elizabeth Dallas

SOURCE: Duke University, news release, May 11, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First Gene Variants Linked to Stuttering Discovered
2. Gene Variant May Help Some Overcome Adversity
3. Genetic Variant Raises Lung Cancer Risk
4. Genetic variant greatly increases lung cancer risk for light smokers
5. Gene Variant May Raise Risk of Common Eye Disease
6. Genetic Variants Tied to MS, Study Finds
7. Success of Hepatitis C Drugs May Depend on Gene Variant
8. Scientists Spot Gene Variants That Predict Longevity
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Spotting Gene Variants May Boost Hepatitis C Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
(Date:9/26/2017)... NJ (PRWEB) , ... September 26, 2017 , ... ... trained orthopedic surgeon and the Chair of the Leg, Ankle, and Foot Section ... is currently the only fellowship trained orthopedic surgeon at Hackensack UMC performing total ...
(Date:9/26/2017)... ... 2017 , ... The 2017 American Academy of Cosmetic Surgery World Congress on ... only the latest about cosmetic procedures to remove and replace fat, but also how ... “Fat really is magical, especially when it comes to the cosmetic patient,” says cosmetic ...
(Date:9/26/2017)... Pittsburgh, PA (PRWEB) , ... September 26, 2017 ... ... new chairmen who are collaborating on strategic and tactical plans for Pittcon 2018. ... Chemistry), took office as president along with his named vice president, Charles Gardner, ...
(Date:9/26/2017)... ... ... Morning Sunshine!: Finding Strength and Comfort in God”: a hopeful and compelling story ... God” is the creation of published author, Terri Braun, a mother of two with ... local mental health center for over twenty years, helping the severely and persistently mentally ...
(Date:9/26/2017)... (PRWEB) , ... September 26, 2017 , ... “Sound of ... Song” is the creation of published author, Karmen Worden, a retired teacher with a ... Worden’s new book is an intriguing and inspiring story on loss, living with depression, ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing ... of targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
Breaking Medicine Technology: