Navigation Links
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
Date:5/13/2011

FRIDAY, May 13 (HealthDay News) -- A common gene variant among black people may be linked to the development of life-threatening heart arrhythmias (when the heart beats too fast, too slow or irregularly), according to a new study.

In pinpointing this gene, Duke University Medical Center researchers hope to one day help doctors determine which patients are likely to benefit most from an implantable cardio-defibrillator (ICD) -- a device that automatically detects and corrects potentially deadly heart rhythms by delivering a jolt of electricity.

Blacks are disproportionately affected by heart failure, arrhythmias and sudden cardiac death, "but are vastly underrepresented in the majority of clinical trials conducted to date," the study's lead author, Dr. Albert Y. Sun, said in a university news release. "Much debate surrounds the identification of patients for ICD implantation, which takes into account efficacy, cost and complication rates."

The study, published in the current issue of the journal Circulation: Cardiovascular Genetics, included 112 black patients who received ICDs for primary prevention of sudden cardiac death. Over a follow-up period that averaged about two years, ICDs were effectively activated in 23 of the patients.

The investigators found that patients with the gene variant, known as the Y1103 allele, were three times more likely have the device triggered because of a potentially life-threatening ventricular arrhythmia. "These findings are significant because approximately 13 percent of people of African descent carry this variant," Sun noted.

Patients with the gene variant also experienced their first arrhythmia 448 days sooner than those without the gene (609 days versus 1,057 days). "This is the largest genetic study to date of blacks with ICDs and it promises potential new diagnostic strategies to define patients who will most benefit from ICDs," concluded the study's principal investigator, Dr. Geoffrey S. Pitt, director of Duke's Ion Channel Research Unit, in the news release.

More information

The American Heart Association offers detailed information on heart arrhythmias.

-- Mary Elizabeth Dallas

SOURCE: Duke University, news release, May 11, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. First Gene Variants Linked to Stuttering Discovered
2. Gene Variant May Help Some Overcome Adversity
3. Genetic Variant Raises Lung Cancer Risk
4. Genetic variant greatly increases lung cancer risk for light smokers
5. Gene Variant May Raise Risk of Common Eye Disease
6. Genetic Variants Tied to MS, Study Finds
7. Success of Hepatitis C Drugs May Depend on Gene Variant
8. Scientists Spot Gene Variants That Predict Longevity
9. Mayo-led researchers discover genetic variants modifying breast cancer risk
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Spotting Gene Variants May Boost Hepatitis C Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, LLC ... by obtaining investment capital for emerging technology companies. SCP has delivered investment ... resulted in more than a million dollars of capital investment for five companies. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... induced pluripotent stem (iPS) cells and other difficult to transfect cells, announces its ... The PluriQ™ G9™ Gene Editing System is a complete system for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... Research and Markets has announced the ... report to their offering. ... favourable commercial environment for MedImmune to enter. The US ageing ... serve to drive considerable growth for effective anti-influenza medications. The ... sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
Breaking Medicine Technology: