Navigation Links
Gene Variant Linked to Failure of Asthma Drug
Date:9/28/2011

WEDNESDAY, Sept. 28 (HealthDay News) -- About one in six asthma sufferers carries a genetic variant that's associated with a poor response to commonly prescribed inhaled asthma medications called corticosteroids, according to a new study.

Researchers found that people with asthma carrying two copies of a specific gene variant were more than twice as likely not to respond to inhaled steroids as those without the variant.

Those who responded poorly showed only about one-third the improvement in lung function in response to steroid inhalers used for the long-term control of asthma than those without the variant.

Researchers said the variant probably works alongside other genetic and environmental factors to affect response to the medication.

"This finding helps to explain the genetic basis for the long-standing observation that some people do not respond well to what is a common asthma treatment," said Dr. Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, in a news release. "The study illustrates the importance of research examining the relationship between genetic makeup and response to therapy for asthma, and underscores the need for personalized treatment for those who have it."

Poor response to inhaled corticosteroids often runs in families, according to the study.

Researchers examined genetic information from more than 1,000 people enrolled in five different clinical trials for various asthma treatments.

The study, published in the Sept. 26 online edition of the New England Journal of Medicine, uncovered a variant in a gene called GLCCI1 linked to poor response to inhaled corticosteroids.

The study's authors noted that the majority of the people studied were white, so the findings may not apply to people of other races or ethnicities. They added that more research is needed to understand how GLCCI1 affects the lungs and whether or not it affects non-white asthma patients.

More information

The U.S. National Heart, Lung, and Blood Institute provides more information on asthma treatments.

-- Mary Elizabeth Dallas

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, September 26, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Variant May Raise Death Risk After Heart Bypass
2. Six new genetic variants linked to type 2 diabetes discovered in South Asians
3. Gene Variants That Boost Lung Cancer Risk Identified
4. Scientists show how gene variant linked to ADHD could operate
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Gene Variant Associated With Asthma Risk in Blacks
7. Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
8. Gene Variant May Be Linked to Deadly Lung Fibrosis
9. Spotting Gene Variants May Boost Hepatitis C Treatment
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Mayo-led researchers discover genetic variants modifying breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a ... survey in an infographic on the current state of anxiety in support of National ... anxiety, was conducted in April 2017 and benchmarked general anxiety levels as well as ...
(Date:5/22/2017)... Kisco, NY (PRWEB) , ... May 22, 2017 , ... ... are urged to receive relaxing sedation dentistry in Mt. Kisco, NY from Advanced Endodontics ... be administered for a variety of treatments. One or more sedation methods may be ...
(Date:5/22/2017)... PITTSBURGH, PA (PRWEB) , ... May 22, 2017 , ... ... way to write with a pen. "My wife’s hand was damaged in a firework ... invent something that helps people with manual problems." , He then designed and created ...
(Date:5/22/2017)... ... 22, 2017 , ... Faithfully following pop culture, people today are forever in ... shaped through fitness programs. It carries on to skin nourished, pampered and nurtured to ... radiant smile. CDA has found that just like a perfectly cut and ...
(Date:5/21/2017)... ... May 19, 2017 , ... Chris Cornell, 52, was found dead on the night of Wednesday, ... most respected lead singers in the rock industry would take his own life, but the ... investigates how mental illness played a role in the death of Chris Cornell . ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
(Date:5/15/2017)... 2017 Enterin Inc., a privately-held CNS pharmaceutical company ... compounds to treat Parkinson,s disease (PD), has enrolled the first ... 1/2a randomized, controlled, multicenter study involving patients with PD and ... patients over a 9-to-12-month period. The first stage is open ... PD. Participating sites include Denver , ...
(Date:5/10/2017)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... quarter ended April 1, 2017 .   GAAP diluted ... to the prior year period as the sale of ... while non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue ... currency terms.  Excluding the effects of blood screening and ...
Breaking Medicine Technology: