Navigation Links
Gene Variant Linked to Failure of Asthma Drug
Date:9/28/2011

WEDNESDAY, Sept. 28 (HealthDay News) -- About one in six asthma sufferers carries a genetic variant that's associated with a poor response to commonly prescribed inhaled asthma medications called corticosteroids, according to a new study.

Researchers found that people with asthma carrying two copies of a specific gene variant were more than twice as likely not to respond to inhaled steroids as those without the variant.

Those who responded poorly showed only about one-third the improvement in lung function in response to steroid inhalers used for the long-term control of asthma than those without the variant.

Researchers said the variant probably works alongside other genetic and environmental factors to affect response to the medication.

"This finding helps to explain the genetic basis for the long-standing observation that some people do not respond well to what is a common asthma treatment," said Dr. Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, in a news release. "The study illustrates the importance of research examining the relationship between genetic makeup and response to therapy for asthma, and underscores the need for personalized treatment for those who have it."

Poor response to inhaled corticosteroids often runs in families, according to the study.

Researchers examined genetic information from more than 1,000 people enrolled in five different clinical trials for various asthma treatments.

The study, published in the Sept. 26 online edition of the New England Journal of Medicine, uncovered a variant in a gene called GLCCI1 linked to poor response to inhaled corticosteroids.

The study's authors noted that the majority of the people studied were white, so the findings may not apply to people of other races or ethnicities. They added that more research is needed to understand how GLCCI1 affects the lungs and whether or not it affects n
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Gene Variant May Raise Death Risk After Heart Bypass
2. Six new genetic variants linked to type 2 diabetes discovered in South Asians
3. Gene Variants That Boost Lung Cancer Risk Identified
4. Scientists show how gene variant linked to ADHD could operate
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Gene Variant Associated With Asthma Risk in Blacks
7. Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
8. Gene Variant May Be Linked to Deadly Lung Fibrosis
9. Spotting Gene Variants May Boost Hepatitis C Treatment
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Mayo-led researchers discover genetic variants modifying breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... John A. Gennaro, FACHE, MBA, MHSA ... Department of Veterans Affairs (VA) is pleased to announce ... director of the Cincinnati VA Medical Center (CVAMC). Gennaro ... 43,000 unique Veterans annually and an operating budget of ... is a two-division campus located in Cincinnati, Ohio and ...
(Date:5/29/2015)... PA (PRWEB) May 29, 2015 ... to be among the first hospitals in the ... to enhance maternity care practices and work toward ... a hospital-based quality-improvement initiative focusing on maternity care ... Centers for Disease Control and Prevention, EMPower is ...
(Date:5/29/2015)... CO (PRWEB) May 29, 2015 ... new addiction, substance abuse, and co-occurring mental health ... and ribbon cutting for the general public on ... 2nd. , The Recovery Village at Palmer Lake ... intensive outpatient programming, utilizing traditional and evidence-based therapies, ...
(Date:5/29/2015)... Angeles, CA (PRWEB) May 29, 2015 The ... greatly in the last decade. New and more efficient methods ... hair available to balding patients. One of the most cutting ... Parsa Mohebi Hair Restoration is the technique of extracting hair ... to scalp transplants are performed to correct male pattern ...
(Date:5/29/2015)... Dot Hill can mark one more item off ... Lake Prince Woods retirement community is the oldest woman to ... , “It was great fun!”, she exclaimed. “I’ve always wanted ... to so they thought this would be ok.” , “We put ... wind tunnel,” she described. “I don’t remember it being noisy, ...
Breaking Medicine News(10 mins):Health News:VA Healthcare System of Ohio Network Announces New Medical Center Director 2Health News:Abington Hospital Selected to Join Baby-Friendly Hospital Initiative 2Health News:Advanced Recovery Systems Announces the Opening of The Recovery Village at Palmer Lake 2Health News:Beard to Scalp Hair Transplant: Newest Advance in Hair Transplant Technology 2Health News:Indoor Skydiving Brings Thrills to Seniors 2
... Lady Laura Bush,today visited the Maamobi Polyclinic in ... two interventions being implemented by AED to control,malaria., ... with Ghana,s commercial,sector to increase the availability and ... in Ghana and five,other sub-Saharan African countries, and ...
... Travel Grant Program For Mesothelioma Patients, CHICAGO, ... Foundation) has established the Mary and Bob Cosentino,Travel ... an,expert on this very grave asbestos-related cancer., ... painfully,invades the lining of the lungs, heart or ...
... to discuss transaction will be hosted at 11:30 am Eastern ... ... Meadowbrook,Insurance Group, Inc. ("Meadowbrook") (NYSE: MIG ) and ProCentury,Corporation ("ProCentury") ... agreement for a transaction valued at,approximately $272.6 million in cash and ...
... Global Limited,unveils the VEGO Power Blocker, the ultimate ... cellphone users could get,away from the hazards of ... Kills the Invisible Killer by Blocking,99.99% of Cellphone ... piece of ultra-thinned film, made by NANO,Technology, coated ...
... arthritis are twice as likely to experience depression but ... according to researchers at the University of North Carolina ... the most common form of chronic inflammatory arthritis ... tissues, persistent pain, functional disability, stiffness and fatigue. , ...
... nonsurgical care for painful condition that often accompanies aging ... study of its kind concludes that surgery is better ... of the spine that stems from the normal deterioration ... operation showed more improvement in pain, function, satisfaction and ...
Cached Medicine News:Health News:First Lady Laura Bush Visits AED/Netmark Malaria-Control Project in Ghana 2Health News:Giving Patients a Lift 2Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 2Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 3Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 4Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 5Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 6Health News:Meadowbrook Insurance Group, Inc. and ProCentury Corporation Reach Agreement to Merge in $272.6 Million Transaction 7Health News:Venture Global Limited Introduces an Innovative Anti-Cellphone Radiation Sticker Named 'VEGO Power Blocker' 2Health News:Doctors should watch for depression in arthritis patients 2Health News:Surgery Best for Narrowing of Spine 2Health News:Surgery Best for Narrowing of Spine 3
(Date:5/29/2015)... May 29, 2015  Hologic, Inc. (NASDAQ: HOLX ... a new, five-year secured credit agreement consisting of a ... revolving credit facility. Hologic has borrowed $0.175 ... proceeds and the Term Loan to pay off the ... aggregate principal amount outstanding of $1.69 billion as of ...
(Date:5/29/2015)... May 29, 2015  Today, UL LLC, a ... global provider of electronic quality management systems (EQMS) ... which will leverage the strengths of both organizations ... system implementation and comprehensive advice and guidance for ... EQMS capabilities to UL,s strength in regulatory services ...
(Date:5/29/2015)... 2015  Excite Medical was established by its President, ... Excite Medical, under the leadership of Mr. Musallam ... a solid track record of providing unparalleled service and ... base.  Photo - http://photos.prnewswire.com/prnh/20150529/219412 ... been possible, in large part, due to Mr. ...
Breaking Medicine Technology:Hologic Enters into Five-Year Secured Credit Agreement 2Hologic Enters into Five-Year Secured Credit Agreement 3UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 2UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 3
... EC 350 consists of two modular units. ... surface and reaches a temperature of -15C. ... reservoir, heated dispenser nozzle, heated work surface, ... separate heated compartments for molds and cassettes. ...
... The exclusive mountant media dispensing ... air bubbles under the coverglass. ... interface with most automated staining ... to load, pre-filled coverglass and ...
... robotic system for spinal procedures. The SpineAssist ... highly accurate, easy-to-use solution that enables surgery ... minimum intervention. SpineAssist currently answers a growing ... guidance devices in pedicle screw insertion for ...
Hydrophobic Acrylic Intraocular Lens, AC depth: 5.3....
Medicine Products: