Navigation Links
Gene Variant Linked to Failure of Asthma Drug
Date:9/28/2011

WEDNESDAY, Sept. 28 (HealthDay News) -- About one in six asthma sufferers carries a genetic variant that's associated with a poor response to commonly prescribed inhaled asthma medications called corticosteroids, according to a new study.

Researchers found that people with asthma carrying two copies of a specific gene variant were more than twice as likely not to respond to inhaled steroids as those without the variant.

Those who responded poorly showed only about one-third the improvement in lung function in response to steroid inhalers used for the long-term control of asthma than those without the variant.

Researchers said the variant probably works alongside other genetic and environmental factors to affect response to the medication.

"This finding helps to explain the genetic basis for the long-standing observation that some people do not respond well to what is a common asthma treatment," said Dr. Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, in a news release. "The study illustrates the importance of research examining the relationship between genetic makeup and response to therapy for asthma, and underscores the need for personalized treatment for those who have it."

Poor response to inhaled corticosteroids often runs in families, according to the study.

Researchers examined genetic information from more than 1,000 people enrolled in five different clinical trials for various asthma treatments.

The study, published in the Sept. 26 online edition of the New England Journal of Medicine, uncovered a variant in a gene called GLCCI1 linked to poor response to inhaled corticosteroids.

The study's authors noted that the majority of the people studied were white, so the findings may not apply to people of other races or ethnicities. They added that more research is needed to understand how GLCCI1 affects the lungs and whether or not it affects non-white asthma patients.

More information

The U.S. National Heart, Lung, and Blood Institute provides more information on asthma treatments.

-- Mary Elizabeth Dallas

SOURCE: U.S. National Heart, Lung, and Blood Institute, news release, September 26, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Gene Variant May Raise Death Risk After Heart Bypass
2. Six new genetic variants linked to type 2 diabetes discovered in South Asians
3. Gene Variants That Boost Lung Cancer Risk Identified
4. Scientists show how gene variant linked to ADHD could operate
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Gene Variant Associated With Asthma Risk in Blacks
7. Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
8. Gene Variant May Be Linked to Deadly Lung Fibrosis
9. Spotting Gene Variants May Boost Hepatitis C Treatment
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Mayo-led researchers discover genetic variants modifying breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed ... consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has ... highest standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. ... recently contributed a medical article to the newly revamped Cosmetic Town journal ... spotlights the hair transplant procedure known as Follicular Unit Extraction (FUE). ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 2017 West Pharmaceutical Services, Inc. ... injectable drug administration, today announced that it will release ... Thursday, October 26, 2017, and will follow with a ... at 9:00 a.m. Eastern Time. To participate on the ... conference ID is 94093362. ...
(Date:10/11/2017)...  True Health, a leader in integrated diagnostics ... National Breast Cancer Awareness month to educate doctors ... Research recently published in ... than 10 million American women are at significant ... BRCA2 and have not had testing. These mutations can ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
Breaking Medicine Technology: