Navigation Links
Gene Variant Linked to Failure of Asthma Drug
Date:9/28/2011

WEDNESDAY, Sept. 28 (HealthDay News) -- About one in six asthma sufferers carries a genetic variant that's associated with a poor response to commonly prescribed inhaled asthma medications called corticosteroids, according to a new study.

Researchers found that people with asthma carrying two copies of a specific gene variant were more than twice as likely not to respond to inhaled steroids as those without the variant.

Those who responded poorly showed only about one-third the improvement in lung function in response to steroid inhalers used for the long-term control of asthma than those without the variant.

Researchers said the variant probably works alongside other genetic and environmental factors to affect response to the medication.

"This finding helps to explain the genetic basis for the long-standing observation that some people do not respond well to what is a common asthma treatment," said Dr. Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, in a news release. "The study illustrates the importance of research examining the relationship between genetic makeup and response to therapy for asthma, and underscores the need for personalized treatment for those who have it."

Poor response to inhaled corticosteroids often runs in families, according to the study.

Researchers examined genetic information from more than 1,000 people enrolled in five different clinical trials for various asthma treatments.

The study, published in the Sept. 26 online edition of the New England Journal of Medicine, uncovered a variant in a gene called GLCCI1 linked to poor response to inhaled corticosteroids.

The study's authors noted that the majority of the people studied were white, so the findings may not apply to people of other races or ethnicities. They added that more research is needed to understand how GLCCI1 affects the lungs and whether or not it affects n
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Gene Variant May Raise Death Risk After Heart Bypass
2. Six new genetic variants linked to type 2 diabetes discovered in South Asians
3. Gene Variants That Boost Lung Cancer Risk Identified
4. Scientists show how gene variant linked to ADHD could operate
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Gene Variant Associated With Asthma Risk in Blacks
7. Gene Variant Linked to Sudden Cardiac Death Risk in Blacks
8. Gene Variant May Be Linked to Deadly Lung Fibrosis
9. Spotting Gene Variants May Boost Hepatitis C Treatment
10. Stanford-led study disproves link between genetic variant, risk of coronary artery disease
11. Mayo-led researchers discover genetic variants modifying breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Praeclarus Press is excited to ... new resource for women in need of lactation support. ... away from their children. Today’s mothers receive very clear ... but often feel unsupported when it comes to balancing ... evidence-based insights, and written by Nancy Mohrbacher, an international ...
(Date:7/12/2014)... 2014 Floor-grade instrument ... out of 5. This above-average score represents favorable ... buyer negotiation power over the three years to ... “during the period, surging demand for healthcare services ... new product development, have placed upward pressure on ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Ladies, it doesn't ... out there. Those who are looking for an affordable gown ... women’s special occasion dresses) to get their dream items. Recently, ... and tea length gowns . Along with that, it is ... can enjoy the special offer; the deadline of this promotion ...
(Date:7/11/2014)... The American Association of Poison Control Centers and ... Senator Bill Nelson (D-FL) for his introduction of the ... 10, 2014. Along with fellow Senate co-sponsors, this bill ... enact rules requiring safer, child-resistant packaging for any liquid ... of the bill include: Sen. Richard Blumenthal (D-CT), Sen. ...
(Date:7/11/2014)... York, New York (PRWEB) July 11, 2014 ... http://www.transvaginalmeshlawsuithelp.com/ ) , filed against Johnson & Johnson’s ... courts, Bernstein Liebhard LLP notes that the Texas ... investigating the company’s marketing of surgical mesh products ... urinary incontinence. According to a report from kens5.com, ...
Breaking Medicine News(10 mins):Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 2Health News:AAPCC Issues Statement on the Introduction of the Child Nicotine Poison Prevention Act of 2014 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4
... ... Honorees were Named, FRANKLIN LAKES, N.J., April 1, 2008 At ... on,Monday night, Anthony Welters, Dr. June E. Osborn and Dr. Nelson L. ... Distinguished Alumni Award, respectively., The event was held at the Union ...
... gone from an art form that largely warned against the ... drug use, according to the first systematic social science study ... is published in the April 2008 issue of Addiction Research ... drug use have increased over time, and drug references increased ...
... body fat, leaving them prone to heart disease, diabetes ... to the contrary, more than half of normal-weight Americans ... their overweight contemporaries, this makes them susceptible to heart ... says. , Men whose body fat is greater than ...
... Hundreds of Hopefuls Participating in National Casting Call ... ... In celebration of Earth Month,Whole Foods Market, the world,s ... eco-conscious,personalities were chosen from hundreds of entries to host its ...
... Fla., April 1, 2008 Valensa International,introduced ... this,year,s Natural Products Expo West Conference. This ... the,historically known benefits of cranberry with D-mannose, ... the Larch tree. The,product is available in ...
... Dispute Resolution Process is ... Expeditious Path to Final Approval -, LAVAL, QC, ... today announced that it has appealed the U.S. Food ... to,the next supervisory level under the FDA,s Formal Dispute ...
Cached Medicine News:Health News:The Changing Face of Medicine: National Medical Fellowships Annual Awards Gala Honors Three Fellows 2Health News:The Changing Face of Medicine: National Medical Fellowships Annual Awards Gala Honors Three Fellows 3Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 2Health News:Drug use increasingly glamorized in rap music, according to new study of 2-decade trends 3Health News:Normal Weight Doesn't Always Equal Healthy Weight 2Health News:Normal Weight Doesn't Always Equal Healthy Weight 3Health News:Whole Foods Market(R) Announces Eco-Conscious Youth Hosts for 'Whole Earth Generation(TM)' Show 2Health News:Whole Foods Market(R) Announces Eco-Conscious Youth Hosts for 'Whole Earth Generation(TM)' Show 3Health News:Whole Foods Market(R) Announces Eco-Conscious Youth Hosts for 'Whole Earth Generation(TM)' Show 4Health News:Crannose(TM) Extra Strength Women's Health Formula Targets Urinary Tract Infections 2Health News:Labopharm Appeals FDA's Decision on Once-Daily Tramadol to Next Supervisory Level After Additional Analysis Supports Efficacy 2Health News:Labopharm Appeals FDA's Decision on Once-Daily Tramadol to Next Supervisory Level After Additional Analysis Supports Efficacy 3
(Date:7/10/2014)... July 11, 2014  Major advances in radiation ... are being highlighted in a three-day Oncology Summit ... from 10-12 July, 2014.  Renowned national and international cancer experts ... practices and exchange knowledge on modern technologies making ... efficient. The Summit will address ...
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., a ... has launched the FreeRunner™ knee brace with new ... from patella mal-tracking return to active lifestyles.  FreeRunner,s ... other braces, providing support when patients need it ... they don,t. Patellofemoral issues are the ...
(Date:7/10/2014)... 10, 2014 Yesterday, former Congressman ... device manufacturing facility. Rep. Kennedy and Dick ... facilitate cutting-edge research in neurological disease and treatment. ... health advocate, Garen Staglin , created One ... fundamental changes that will radically accelerate the development ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... -- Simcere Pharmaceutical Group ("Simcere" or the "Company") ... company specializing in the development, manufacturing, and marketing ... announced the resignation of chief financial officer Mr. ... 2011. Simcere,s Board of Directors has appointed Mr. ...
... Webmedx , the third largest medical transcription service, ... U.S., today announced it has received the Best in ... Top 20 Best in KLAS Awards: Software & Professional Services ... 2010 award, the company was also rated No. 1 in ...
Cached Medicine Technology:Simcere Pharmaceutical Group Announces Resignation of CFO Frank Zhao 2Webmedx Named Best in KLAS and Ranked #1 Transcription Services Vendor for Second Year in a Row 2Webmedx Named Best in KLAS and Ranked #1 Transcription Services Vendor for Second Year in a Row 3
... Line catheter is inserted into the subclavian ... superior vena cava. The Cool Line ... sterile, temperature-controlled saline flowing within a closed-loop ... central circulation. The Cool Line combines ...
... provides maximum heat exchange power with ... Fortius catheter incorporates a proprietary serpentine ... ultimate solution for endovascular cooling therapy. ... into the femoral vein residing in ...
...
...
Medicine Products: