Navigation Links
Gene Variant Doubles Risk of Prostate Cancer in Black Men
Date:11/2/2007

It may also affect other populations, researcher says

FRIDAY, Nov. 2 (HealthDay News) -- A variant of a gene that doubles the risk of prostate cancer in black men has been identified, and researchers say the discovery could lead to new treatments.

Almost twice as many black men develop prostate cancer as white men, researchers report. This study confirms that common genetic variants are linked to increased risk for prostate cancer. One of these variants, on the 8q24 gene, confers a particularly significant risk to black men.

"We found a gene involved in increased risk for prostate cancer in African-Americans," said lead researcher Rick Kittles, an associate professor of medicine at the University of Chicago. "This gene is involved in DNA repair."

In the study, Kittles' team looked at the 8q24 region of chromosome 8 and compared genotypes of 490 black men with prostate cancer to 567 controls.

Their report was published in the Oct. 31 online edition of Genome Research.

Finding these variants enables researchers to find out how the gene works in prostate cancer, Kittles said. "We hope to find more treatment options, or even prevention," he added.

"This gene is not exclusive to African-Americans," Kittles stressed. "This variant may be in higher frequency in African-Americans, but it's not exclusive to African-Americans."

Kittles' team is looking at this variant in other populations to try to determine how much of a role it plays in the risk for prostate cancer in other groups of men. "We know the variant is there. We need to see if it is involved in prostate cancer risk in these populations, too," he said.

Prostate cancer is the second leading cause of cancer death among men. This year, 27,000 men in the United States will die from the disease, according to the American Cancer Society. Black men have the highest rates of prostate cancer worldwide.

One expert thinks this study adds to an understanding of prostate cancer but has no immediate clinical application.

"It is encouraging that we are starting to identity some of these regions on the human genome that may be associated with an increased risk for prostate cancer," said Dr. Durado Brooks, director of prostate and colorectal cancer at the American Cancer Society. However, "it is unlikely that this is the only one," he added.

This variant doesn't seem to be associated with the aggressiveness of the disease, Brooks said. "It's important, but we are still a long way from having any strong clinical applicability from these findings," he said.

More information

For more on prostate cancer, visit the U.S. National Cancer Institute.



SOURCES: Rick Kittles, Ph.D., associate professor, medicine, University of Chicago; Durado Brooks, M.D., director, prostate and colorectal cancer, American Cancer Society, Atlanta; Oct. 31, 2007, Genome Research online


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene variant foretells diabetic neuropathy
2. Gene Variants Linked to Early Heart Attack Discovered
3. Sugar variant may make a world of difference to Alzheimers disease
4. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
5. Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants
6. Tougher Guidelines Needed To Prevent Variant Creutzfeldt-Jakob Disease
7. Gene variants hold clues about vulnerability to cardiovascular disease
8. Gene Variant associated with Schizophrenia identified
9. You may Live Long and Think Clear With a Variant Gene
10. Gene Variants Linked to Preterm Birth in Hispanic Women
11. Gene Variant Responsible for Acquiring Intellect and Memory in Humans Identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Doubles Risk of Prostate Cancer in Black Men
(Date:5/2/2016)... , ... May 02, 2016 , ... ... in Huntington Beach, California announced today the release of Grow Healthy Vending’s newly ... is one of the fastest growing healthy vending providers in North America with ...
(Date:5/2/2016)... ... ... This week Omega Institute, a premier nonprofit educational retreat center in New York’s ... offering a record 370 in-person workshops and new online learning opportunities and live ... or need for the knowledge and skills we’ve been cultivating for nearly 40 years. ...
(Date:5/2/2016)... ... 02, 2016 , ... The 2016 World Ultimate & Guts Championship (WUGC) Mixed roster was announced ... the cut. The WUGC is being held in London, England this year from June 18-25. ... men’s division, another gold in the women’s masters division, and a silver in the women’s ...
(Date:5/2/2016)... ... May 02, 2016 , ... TeleMedCo™, ... facilities designed to automate and improve the rapid diagnosis, triage and admission of ... their platform, application, and mobile experience for the first time at GENBAND’s Perspectives16 ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... improve adherence, transition of care and quality outcomes, has announced its partnership with ... innovative, independent pharmacy that provides over the counter and prescription drug pharmacy services ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... 2, 2016 The global  ... 11.1 billion by 2024, according to a new ... drivers of the sonography market include expanding applications ... recommendations for periodic ultrasound screenings of the breast ... http://photos.prnewswire.com/prnh/20150105/723757 ) High Intensity Focused ...
(Date:4/29/2016)... PARIS , April 29, 2016 ... Jérôme Contamine, Directeur Financier ... la santé, publie ses résultats pour ... Financier du Groupe, Jérôme Contamine, commente ... Groupe et les perspectives pour le ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
Breaking Medicine Technology: