Navigation Links
Gene Variant Doubles Risk of Prostate Cancer in Black Men
Date:11/2/2007

It may also affect other populations, researcher says

FRIDAY, Nov. 2 (HealthDay News) -- A variant of a gene that doubles the risk of prostate cancer in black men has been identified, and researchers say the discovery could lead to new treatments.

Almost twice as many black men develop prostate cancer as white men, researchers report. This study confirms that common genetic variants are linked to increased risk for prostate cancer. One of these variants, on the 8q24 gene, confers a particularly significant risk to black men.

"We found a gene involved in increased risk for prostate cancer in African-Americans," said lead researcher Rick Kittles, an associate professor of medicine at the University of Chicago. "This gene is involved in DNA repair."

In the study, Kittles' team looked at the 8q24 region of chromosome 8 and compared genotypes of 490 black men with prostate cancer to 567 controls.

Their report was published in the Oct. 31 online edition of Genome Research.

Finding these variants enables researchers to find out how the gene works in prostate cancer, Kittles said. "We hope to find more treatment options, or even prevention," he added.

"This gene is not exclusive to African-Americans," Kittles stressed. "This variant may be in higher frequency in African-Americans, but it's not exclusive to African-Americans."

Kittles' team is looking at this variant in other populations to try to determine how much of a role it plays in the risk for prostate cancer in other groups of men. "We know the variant is there. We need to see if it is involved in prostate cancer risk in these populations, too," he said.

Prostate cancer is the second leading cause of cancer death among men. This year, 27,000 men in the United States will die from the disease, according to the American Cancer Society. Black men have the highest rates of prostate cancer worldwide.

One expert thinks this study adds to an understanding of prostate cancer but has no immediate clinical application.

"It is encouraging that we are starting to identity some of these regions on the human genome that may be associated with an increased risk for prostate cancer," said Dr. Durado Brooks, director of prostate and colorectal cancer at the American Cancer Society. However, "it is unlikely that this is the only one," he added.

This variant doesn't seem to be associated with the aggressiveness of the disease, Brooks said. "It's important, but we are still a long way from having any strong clinical applicability from these findings," he said.

More information

For more on prostate cancer, visit the U.S. National Cancer Institute.



SOURCES: Rick Kittles, Ph.D., associate professor, medicine, University of Chicago; Durado Brooks, M.D., director, prostate and colorectal cancer, American Cancer Society, Atlanta; Oct. 31, 2007, Genome Research online


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene variant foretells diabetic neuropathy
2. Gene Variants Linked to Early Heart Attack Discovered
3. Sugar variant may make a world of difference to Alzheimers disease
4. Striking a Gold Mine: H5N1 Vaccine may Serve as an Antidote for Mutants and Variants
5. Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants
6. Tougher Guidelines Needed To Prevent Variant Creutzfeldt-Jakob Disease
7. Gene variants hold clues about vulnerability to cardiovascular disease
8. Gene Variant associated with Schizophrenia identified
9. You may Live Long and Think Clear With a Variant Gene
10. Gene Variants Linked to Preterm Birth in Hispanic Women
11. Gene Variant Responsible for Acquiring Intellect and Memory in Humans Identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Doubles Risk of Prostate Cancer in Black Men
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... 24, 2016 , ... Puradigm® & Innovative Solutions today announced ... and processing operations at its production facility, and opened its first two dispensaries ... manufacturer of a complete system of proactive air and surface purification solutions for ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Issue 52" report to their offering. ... treatment creates a favourable commercial environment for MedImmune to enter. ... base that will serve to drive considerable growth for effective ... serve to cap sales considerably, but development is still in ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), ... company,s second affiliate in Latin America . ... ... Colombia ... ...
Breaking Medicine Technology: