Navigation Links
Gene Variant Boosts Risk of Severe Diabetic Eye, Kidney Diseases
Date:5/8/2008

Finding suggests careful use of blood-boosting drugs in anemia patients

THURSDAY, May 8 (HealthDay News) -- A gene called erythropoietin (EPO) is linked to severe diabetic eye and kidney diseases, a new study finds.

The study, led by a researcher at the John A. Moran Eye Center at the University of Utah, included 1,618 people with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) and 954 diabetic patients without any eye or kidney disease.

PDR is the most common cause of legal blindness in working-age adults in the United States, accounting for 10 percent of new onset blindness overall. Diabetes is the leading cause of ESRD.

The researchers found that people with a copy of mutant EPO gene have an increased risk of developing PDR and ESRD.

"We know that the development of PDR and ESRD in diabetic patients can be inherited. Although genetic factors are known to be important in the susceptibility [or resistance] to these complications, until now, the genes involved have been mostly unknown," study leader Dr. Kang Zhang, director of the division of ophthalmic genetics at the Moran Eye Center and an associate professor of ophthalmology and visual sciences, said in a prepared statement.

The study was published online May 5 in the Proceedings of the National Academy of Sciences.

This finding may affect the use of EPO in treating patients with anemia, Zhang said.

EPO is used extensively to help in the production of red blood cells when treating patients with anemia resulting from renal failure or chemotherapy. In the United States, erythropoietin represents one of the largest single drug expenses for the Center for Medicare & Medicaid Services, approximately one billion dollars per year," Zhang said.

"Patients with anemia due to chronic renal disease [many of whom have diabetes] who receive frequent dosing of EPO to maintain higher hem
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Gene Variant Boosts Risk for Stress-Related Ischemia
2. Gene Variant Protects Black Heart Failure Patients
3. Gene Variants Linked to Lung Cancer Identified
4. Gene Variants Can Predict Threat of Heart Disease
5. Gene variant predicts medication response in patients with alcohol dependence
6. Gene variant linked to moderated symptoms of beta-thalassemia
7. Gene Variant Tied to More Aggressive Prostate Cancer
8. Gene Variant Doubles Risk of Prostate Cancer in Black Men
9. Scientists discover genetic variant associated with prostate cancer in African Americans
10. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
11. Obesity-Related Inflammation Boosts Heart Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... 30, 2015 , ... Between 2012 and 2014 HIV infection rates rose from ... on June 17th. Those untreated heroin use disorders share their needles and spread the ... needles throughout the community. Ultimately Florida’s HIV infection rates have bolstered to 23 percent ...
(Date:7/30/2015)... Dana Point, CA (PRWEB) , ... July 30, 2015 , ... ... the highest honors available, including the very rare “no recommendations.” No recommendations means CARF ... full compliance; this is a notation that less than 3% of all facilities receive. ...
(Date:7/30/2015)... Alexandria, VA (PRWEB) , ... July 30, 2015 ... ... applauds Drug Enforcement Administration (DEA) Acting Administrator Chuck Rosenberg’s announcement of the reinstitution ... been scheduled for Saturday, September 26, 2015 from 10:00 AM to 2:00 PM ...
(Date:7/30/2015)... ... July 30, 2015 , ... The Tisch ... Institute Designation , The Tisch Cancer Institute (TCI) at the Icahn School of ... center. TCI joins an elite group of 69 cancer institutions nationwide that have ...
(Date:7/30/2015)... PA (PRWEB) , ... July 30, 2015 , ... ... inventor from Texas, has designed a personal-care device that makes it easy to apply ... Buddy” could eliminate the need for assistance when applying lotion or medication to the ...
Breaking Medicine News(10 mins):Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 2Health News:HIV Rates Rise in S. Florida, Harbor Village Comments on Health News Florida's Recent Article 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2Health News:AAPCC Supports National Prescription Drug Take-Back Day 2Health News:AAPCC Supports National Prescription Drug Take-Back Day 3Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 2Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 3Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 4Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 5Health News:The Tisch Cancer Institute at Icahn School of Medicine at Mount Sinai Earns National Cancer Institute Designation 6Health News:InventHelp® Client Patents “My Back Buddy” – Device Could Apply Lotion to Hard-to-Reach Areas Easily 2
... The following is a,statement in response to Patrick Swayze ... CEO of the Pancreatic Cancer,Action Network, the only national ... support, community outreach and,advocacy for a cure., "We ... with,pancreatic cancer and our thoughts go out to him ...
... WASHINGTON and NEWARK, N.J., March 5 Besler,& ... principal, Philip,Besler, have agreed to pay the United ... fraud against the federal Medicare program, the,Justice Department ... the North Brunswick,N.J.-headquartered company counseled hospital clients to ...
... MINNEAPOLIS, March 5 As two of the ... implementation of the Freedom,to Breathe Act, we are ... denounced so-called "theatrical performances" in bars as a,violation ... Freedom to Breathe Act was passed to protect ...
... could use,a little pampering now and then. Think your mom ... Breast Cancer Coalition,(PBCC) and Doneckers of Ephrata take care of ... in 250 words or less why your mom, as a,breast ... and you and your mom could be in for a ...
... says , , WEDNESDAY, March 5 (HealthDay News) -- Variations ... warfarin are important in determining the initial doses of ... is being put to medical use. Last August, the ... say that doctors should consider a genetic test when ...
... Spheris, a leading global,provider of clinical documentation technology and ... results for the fourth quarter,ended December 31, 2007., ... fourth quarter of,2007 after the close of market trading ... call on Thursday, March 27, 2008, at 8:00 a.m. ...
Cached Medicine News:Health News:Patrick Swayze's Diagnosis With Pancreatic Cancer: a Statement From the Pancreatic Cancer Action Network 2Health News:New Jersey Healthcare Consulting Firm to Pay U.S. $2.875 Million to Resolve Allegations of Medicare Fraud 2Health News:Leading Health Groups Strongly Support the Minnesota Department of Health's Efforts to Enforce Freedom to Breathe Act 2Health News:The Pennsylvania Breast Cancer Coalition Announces Last Chance to Enter 'Makeover for Mom' Contest 2Health News:Genetic Test Predicts Response to Warfarin 2Health News:Genetic Test Predicts Response to Warfarin 3
(Date:7/30/2015)...  Medimetriks Pharmaceuticals, Inc. announced today that its ... study for Ozenoxacin, a novel bactericidal non-fluorinated quinolone ... U.S. rights to Ozenoxacin 1% cream.  ... with an emphasis on U.S. patients, involved 412 ... older with a clinical diagnosis of bullous or ...
(Date:7/30/2015)... , July 30, 2015 Vermillion, ... on gynecologic disease, announced today it will ... after the market close on Thursday, August ... call and webcast at 4:30pm Eastern.Conference Call ... at 4:30pm Eastern/1:30pm Pacific  Domestic: ...
(Date:7/30/2015)... , July 30, 2015  Big Cloud Analytics, ... analytics technology, announces it is working with Intel ... for the new Lockheed Martin Healthcare Technology Alliance. ... health information technology providers, medical technology companies and ... and innovation to improve care in rapidly evolving ...
Breaking Medicine Technology:Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 2Medimetriks Pharmaceuticals, Inc. Announces Completion of the Second Successful Pivotal Phase III Study for Ozenoxacin 3Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 2Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 3
Quantitative determination of Fibrinogen by STA Analyzers (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and calcium....
Determination of Prothrombin Time (PT) by STA Analyzers (ISI~1.3).Freeze-dried rabbit brain thromboplastin with heparin inhibitor....
The ALB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of albumin in serum...
The PHOS method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of phosphorus in serum....
Medicine Products: