Navigation Links
Gene Variant Boosts Risk for Stress-Related Ischemia
Date:4/22/2008

Patients 3 times more likely to suffer dangerous spike in blood flow to heart, study finds

TUESDAY, April 22 (HealthDay News) -- Researchers have identified a gene variation in heart disease patients who are so vulnerable to the physical effects of mental stress that it causes a major reduction in blood flow to the heart, a condition called ischemia.

Patients with this particular variation of the adrenergic beta-1 receptor gene are three times more likely to experience stress-induced ischemia, which increases the risk of heart attack, heart rhythm abnormalities or sudden death. Mental stress-related ischemia occurs in about 10 percent of all patients with heart disease.

"Searching for the presence of this gene may be one way to better identify patients who are at increased risk for the phenomenon," Dr. David S. Sheps, associate chairman of cardiovascular medicine at the University of Florida's College of Medicine and the Malcolm Randall Veterans Affairs Medical Center, said in a prepared statement.

In this study, University of Florida researchers had 148 coronary artery disease patients, average age 65, perform a public speaking test designed to induce stress. Blood flow to the heart was measured while the patients did the speech task and while they were resting, and patients' blood samples were analyzed for five common gene variations.

About one-quarter of the patients in the study experienced stress-induced reduced blood flow to the heart, and about two-thirds of them had the particular variation of the adrenergic beta-1 receptor gene associated with increased risk for stress-induced ischemia.

The adrenergic beta-1 receptor typically helps the body respond to stress by regulating blood pressure and heart rate. But this common variation makes patients more susceptible to the effects of stress, the researchers explained.

The study was published in the April 14 issue of the Archives of Internal Medicine.

UF researchers are looking for other genetic subtypes that could identify other patients at increased risk for stress-related ischemia.

"We should focus our research on two areas," Sheps said. "One is better identification of patients who are prone to have this problem, and two is looking for effective treatments once we know they have it. We need to know whether we can reverse this phenomenon. We are embarking on other treatment studies fairly soon."

More information

The American Heart Association has more about ischemia.



-- Robert Preidt



SOURCE: University of Florida, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
2. Scientists discover genetic variant associated with prostate cancer in African Americans
3. Gene Variant Doubles Risk of Prostate Cancer in Black Men
4. Gene Variant Tied to More Aggressive Prostate Cancer
5. Gene variant linked to moderated symptoms of beta-thalassemia
6. Gene variant predicts medication response in patients with alcohol dependence
7. Gene Variants Can Predict Threat of Heart Disease
8. Gene Variants Linked to Lung Cancer Identified
9. Gene Variant Protects Black Heart Failure Patients
10. New treatment boosts muscle function in myasthenia gravis
11. Heavy Drinking Boosts Stroke Risk for Chinese Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... From a health perspective, 2017 will clearly be the Year ... chronic disease, mental health and general physical well-being. The New York Times suggested a ... , For one Charlottesville restaurant, good gut health is clearly on the menu. ...
(Date:1/18/2017)... ... January 18, 2017 , ... The V Foundation for Cancer ... its official endurance training and fundraising team, to compete in the Boston Marathon on ... inspired to finish the world’s oldest annual marathon to join Team V and support ...
(Date:1/18/2017)... ... January 18, 2017 , ... At Hallmark Nameplate, their ... that they have achieved certification to ISO 13485. This certification is another way they ... to date products and services that they need. , The ISO 13485 Certification is ...
(Date:1/18/2017)... ... January 18, 2017 , ... Rollerblade®, ... Brake Technology (ABT), an innovative braking system that allows skaters of all levels ... one of the biggest concerns of beginner and intermediate skaters – learning how ...
(Date:1/17/2017)... ... January 17, 2017 , ... Gym Source, America’s leading ... new showroom at South Dixie Hwy in Miami, FL. , “We are elated to ... “The new innovative in-store concept is designed to give clients a seamless and motivating ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... NEW YORK , January 18, 2017 ... perception of people regarding the use of cannabis both for ... not only are more Americans open to the use of ... and financial sectors. According to Arcview Market Research, the North ... 2016, up 30% from the previous year. The research projects ...
(Date:1/18/2017)... and Drug Administration CSL CureVac Daiichi ... Drug Administration FORT Fresenius Pharmaceuticals Gamma ... GlaxoWellcome Global Influenza Programme Grippol ... Targeting Systems Indian Association of Paediatrics Janssen Pharmaceuticals ... Krka Pharmaceuticals Medicago Medicare ...
(Date:1/17/2017)... Jan. 17, 2017 Secretary of Health Dr. ... Secretary Gary Tennis are warning Pennsylvanians of ... recent overdose deaths from the drug in ... intended to sedate large animals and is not meant ... comes into contact with it," Secretary Murphy said. "It,s ...
Breaking Medicine Technology: