Navigation Links
Gene Variant Boosts Risk for Stress-Related Ischemia
Date:4/22/2008

Patients 3 times more likely to suffer dangerous spike in blood flow to heart, study finds

TUESDAY, April 22 (HealthDay News) -- Researchers have identified a gene variation in heart disease patients who are so vulnerable to the physical effects of mental stress that it causes a major reduction in blood flow to the heart, a condition called ischemia.

Patients with this particular variation of the adrenergic beta-1 receptor gene are three times more likely to experience stress-induced ischemia, which increases the risk of heart attack, heart rhythm abnormalities or sudden death. Mental stress-related ischemia occurs in about 10 percent of all patients with heart disease.

"Searching for the presence of this gene may be one way to better identify patients who are at increased risk for the phenomenon," Dr. David S. Sheps, associate chairman of cardiovascular medicine at the University of Florida's College of Medicine and the Malcolm Randall Veterans Affairs Medical Center, said in a prepared statement.

In this study, University of Florida researchers had 148 coronary artery disease patients, average age 65, perform a public speaking test designed to induce stress. Blood flow to the heart was measured while the patients did the speech task and while they were resting, and patients' blood samples were analyzed for five common gene variations.

About one-quarter of the patients in the study experienced stress-induced reduced blood flow to the heart, and about two-thirds of them had the particular variation of the adrenergic beta-1 receptor gene associated with increased risk for stress-induced ischemia.

The adrenergic beta-1 receptor typically helps the body respond to stress by regulating blood pressure and heart rate. But this common variation makes patients more susceptible to the effects of stress, the researchers explained.

The study was published in the April 14 issue of the Archives of Internal Medicine.

UF researchers are looking for other genetic subtypes that could identify other patients at increased risk for stress-related ischemia.

"We should focus our research on two areas," Sheps said. "One is better identification of patients who are prone to have this problem, and two is looking for effective treatments once we know they have it. We need to know whether we can reverse this phenomenon. We are embarking on other treatment studies fairly soon."

More information

The American Heart Association has more about ischemia.



-- Robert Preidt



SOURCE: University of Florida, news release, April 14, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
2. Scientists discover genetic variant associated with prostate cancer in African Americans
3. Gene Variant Doubles Risk of Prostate Cancer in Black Men
4. Gene Variant Tied to More Aggressive Prostate Cancer
5. Gene variant linked to moderated symptoms of beta-thalassemia
6. Gene variant predicts medication response in patients with alcohol dependence
7. Gene Variants Can Predict Threat of Heart Disease
8. Gene Variants Linked to Lung Cancer Identified
9. Gene Variant Protects Black Heart Failure Patients
10. New treatment boosts muscle function in myasthenia gravis
11. Heavy Drinking Boosts Stroke Risk for Chinese Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... , ... The Case Management Society of America (CMSA) will install six new ... membership has elected their upcoming President-Elect, Secretary, Treasurer and two Directors to serve on ... Advisory position has also been added to the BOD, per an appointment made by ...
(Date:3/27/2017)... ... March 27, 2017 , ... EpiGentek ... to pursue the recent RNA methylation “gold rush” with their established portfolio of ... newfound characteristics of N6-methyladenosine, or m6A , RNA methylation has received a ...
(Date:3/27/2017)... Foothill Ranch, California (PRWEB) , ... March 27, 2017 , ... ... company’s commitment to its customers. First National Capital has added 10 new sales professionals ... to grow its sales positions by 15 additional new hires over the course of ...
(Date:3/27/2017)... RICHEY, Fla. (PRWEB) , ... March 27, 2017 ... ... drug overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of ... Kevin McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on ...
(Date:3/25/2017)... ... March 25, 2017 , ... Norland at Swissray is pleased to announce the ... subjects. The ELITE DXA has an active scan window, which is more than double ... fit in the scan area could not undergo an accurate total body bone density or ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... 2017  A recent study at Shriners Hospitals for ... in the country dedicated to the treatment of pediatric ... that the Surfacide Helios ® UV-C Disinfection System ... bacterial pathogens not killed by the EVS (manual) cleaning ... American Burn Association,s 49th Annual Meeting in ...
(Date:3/27/2017)... IRVINE, Calif. , March 27, 2017  Cryoport, ... announced that it intends to offer shares of common ... shelf registration statement on file with the Securities and ... market and other conditions, and there can be no ... be completed, or as to the actual size or ...
(Date:3/27/2017)... , March 27, 2017 ... attendees and more than 600 exhibitors from 70 ... opportunities and solutions that will advance the medical ... 2017 at the Messe Stuttgart, Stuttgart, ... medical technology platform showcasing the key trends and ...
Breaking Medicine Technology: