Navigation Links
Gene Variant Allies Autism, Gastrointestinal Woes
Date:3/2/2009

It's associated with both brain development and GI system functions, study finds

MONDAY, March 2 (HealthDay News) -- Researchers have identified a gene variant that is associated with both autism and gastrointestinal problems in individuals with autism.

The finding may represent early identification of a sub-type of autism.

"This association was not present in another group who have autism and don't have gastrointestinal problems," said study author Dr. Daniel B. Campbell, a research assistant professor of pharmacology at Vanderbilt University in Nashville. "We think we're subdividing types of autism in a way that's finally useful."

The report was published in the March issue of Pediatrics.

Autism is widely recognized to be not one condition, but a collection of very heterogeneous disorders. Many prefer to use the term "autism spectrum disorders" (ASD) to describe the variety.

Several studies have now shown an association between ASD and this specific genetic variant.

The study authors put this together with the fact that 30 percent to 70 percent of children with autism have GI problems and the fact that the MET C gene is involved with both brain development and how the GI system functions.

"It's involved in how well it repairs itself, how well it responds to insults, taking in foods that upset the stomach," Campbell explained. "We wondered if this MET gene variant that we'd identified two years ago might be involved specifically in a subset of these patients who have both autism and a GI problem."

The authors looked at medical histories and genetic profiles of 918 individuals with autism from 214 families.

The MET C allele was linked with autism spectrum disorder and GI problems in 118 families who had at least one child with both conditions.

No such link was found in the remaining 96 families who did not have a child with both autism and GI conditions.

"It looks like this particular genetic variation affects cellular processes in the brain during development and in the gut for your whole life," said Keith Young, vice chair for research for the department of psychiatry and behavioral science at Texas A&M Health Science Center College of Medicine and neuroimaging and genetics core leader at VA Center of Excellence for Research on Returning War Veterans, part of the Central Texas Veterans Health Care System.

"What we predict is going to happen is that other genes that provide proteins for this pathway might be affected in those families, so they're not going to show up with a gut problem, but they can still get autism," continued Young, who was recently named chair of the Tissue Advisory Board for Autism Speaks, a group that aims to increase awareness about autism and to fund research into the disorder. "The long-term importance of this is it's providing information about this cellular pathway where we can start looking to find out what it has to do with development. . . This gene is found more in social parts of the brain."

This line of research may turn up targets for new drugs.

Although the finding is not likely to change the lives of individuals with autism in the near future, Campbell said, "It's important for the public to know that GI problems are present in autism. And in this particular set of individuals who have problems with communication, it's not always that obvious that they have GI problems. Often they can't say, 'My tummy hurts.' They have to find other ways to express that, and it's not always productive."

More information

Visit Autism Speaks for more about this condition.



SOURCES: Daniel B. Campbell, Ph.D., research assistant professor, pharmacology, Vanderbilt University, Nashville; Keith Young, Ph.D., vice chair, research, department of psychiatry and behavioral science, Texas A&M Health Science Center College of Medicine, neuroimaging and genetics core leader, VA Center of Excellence for Research on Returning War Veterans, Central Texas Veterans Health Care System, and chair, Tissue Advisory Board, Autism Speaks; March 2009, Pediatrics


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gene Variant Raises Risk of Uterine Fibroids
2. Gene Variant Tied to Severity of Drinking
3. Gene Variant Raises Risk for Brain Cancer at Young Age
4. Gene Variant May Hike Womens Risk of Alzheimers
5. Biologist finds plant polymerases IV and V are really variants of Polymerase II
6. Gene Variant Tied to Smokers Risk of Lung Cancer
7. Genetic Variants Tied to Obesity
8. NEW Line of Pushbutton Pill Cases Launched by Variant Products
9. Newly found gene variants account for kidney diseases among African-Americans
10. Genetic variants associated with vitamin B12
11. APA resolves to play leading role in improving treatment for gender-variant people
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Variant Allies Autism, Gastrointestinal Woes
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... in a medical capacity this year. Drs. Alexander Paziotopoulos, Andrew Petersen and Trish ... a condensed version of the clinic’s leading recovery program. , “We know ...
(Date:1/19/2017)... ... 19, 2017 , ... Bio-Optronics Inc. is proud to announce ... designed to seamlessly integrate and streamline the way researchers prepare and conduct patient ... usability and improving efficiency significantly for users – a first in the CTMS ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... panel system. , The Tranquility privacy panel system was designed to deliver ... Tranquility panels help reduce noise and provide the visual privacy required to maintain ...
(Date:1/19/2017)... ... January 19, 2017 , ... Rountree ... planning services to communities throughout eastern Georgia, is embarking on a charity effort ... Heart disease kills more Americans every year than anything else, yet risk factors ...
(Date:1/19/2017)... , ... January 19, 2017 , ... Attorney Robert ... fifth consecutive year donated money to the Triumph Over Kid Cancer foundation. Each year, ... one of those children. James saw firsthand the effect of the critical funding gap ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... and Markets has announced the addition of the "Vital Signs Monitoring ... Industry Forecast, 2014-2022" report to their offering. ... Vital signs monitoring market size was worth $3,694 ... growing at a CAGR of 5.8% from 2016 to 2022. ... in global vital signs monitoring devices industry. The blood pressure monitoring devices ...
(Date:1/18/2017)... SAN JOSE, Calif. , Jan. 18, 2017  Adaptive ... machines, announced today a new partnership with Hyatt Place ... guests by providing ASTI LectroFan sleep therapy machines in ... "Obviously one of the most important parts of having ... Wicks , general manager of Hyatt Place Nashville/Downtown. "We,re ...
(Date:1/18/2017)... LITTLE FALLS, N.J. , Jan. 18, 2017 /PRNewswire/ ... RGIN ), a biotechnology company specializing in the development ... health of damaged tissues and organs, recently reported the ... key milestones for 2017. As the Company ... 2016 has been a year of substantial accomplishments. The ...
Breaking Medicine Technology: