Navigation Links
Gene-Transfer Proves Safe for Vision Problem
Date:9/12/2008

Volunteers with rare eye disease regained partial sight with experimental therapy

FRIDAY, Sept. 12 (HealthDay News) -- Three people with a rare, incurable form of hereditary blindness regained some sight after receiving experimental gene therapy, a new report says.

The patients, all in their early 20s, have Leber congenital amaurosis type 2 (LCA2), a disease in which photoreceptor cells cannot respond to light, because a gene called RPE65 does not properly produce a protein necessary for healthy vision.

In the study, published online in Human Gene Therapy, researchers at the University of Florida used an adeno-associated virus. an apparently harmless virus that already exists in most people. to deliver RPE65 to a small area of the retina.

The subjects said the vision in their treated eyes was slightly improved in dim lighting conditions.

"The patients report seeing brighter areas and perhaps some images, but basically the message is that this treatment is fully safe," William W. Hauswirth, a professor of ophthalmology and member of the university's Powell Gene Therapy Center, said in a news release issued by the university.

No ill effects, other than routine post-surgical soreness, were reported.

"The study has partially restored vision in three young adults, and it demonstrates that gene therapy can be effective in treating human vision disease," Dr. Paul A. Sieving, director of the National Eye Institute, which supported the experiment, said in the same news release. "Many human diseases are inherited in families and result from mutations in single genes. These genetic conditions are particularly suited to potential treatment by gene therapy. This trial to treat vision loss from the condition of Leber congenital amaurosis is an important demonstration of proof of principle and shows that we are on the right track. We can now invest in further work to refine, and ultimately to expand, genetic treatment approaches."

A detailed examination of the therapy's effectiveness in the treated portion of the eye was expected to be published in an upcoming issue of the Proceedings of the National Academy of Sciences.

LCA2 affects about 2,000 people in the United States and is one of several incurable forms of blindness collectively known as retinitis pigmentosa, which in turn affects about 200,000 Americans.

More information

The Prevent Blindness America has more about retinitis pigmentosa .



-- Kevin McKeever



SOURCE: University of Florida, news release, September 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Music Therapy Improves Well-Being of Very Ill Patients
2. Safety study indicates gene therapy for blindness improves vision
3. New study finds that add-on therapy improves depressive symptoms in bipolar disorder
4. FDA approves first drug for Huntingtons disease
5. Light Stretching Improves Range of Joint Motion
6. The California Board of Registered Nursing Approves Affiliations for Nursing Program in Glendale, California
7. Free White Paper: Hospital Tests Patient Lift Technologies; Improves Quality of Care
8. Overcoming inhibitors of cell death improves cancer therapy efficacy
9. New study shows calcium significantly improves childrens bone health
10. Madrid Hospital Improves Employee Safety With Ekahau Wi-Fi RTLS
11. Kaiser Permanente Approves $22 Million in Community Benefit Grants in Second Quarter of 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... Altamonte Springs, FL (PRWEB) , ... February 09, ... ... nation’s leading innovative specialty pharmacies, announces today the continuation of the ‘Pay It ... donations for each prescription referral received at our specialty pharmacy. , “Since ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul McElwee, ... after they noticed their furnace not producing any heat. Shortly after entering the home, ... heat exchanger was leaking dangerous levels of carbon monoxide into the home, at 2,000 ...
(Date:2/9/2016)... WI (PRWEB) , ... February 09, 2016 , ... ... Bergner’s, Boston Store, Carson’s, Elder-Beerman, Herberger’s and Younkers department stores, announced it has ... College of Wisconsin Cancer Center, Holden Comprehensive Cancer Center at the University of ...
(Date:2/9/2016)... Diego, California (PRWEB) , ... February 09, 2016 ... ... launch of their new nationwide service to expand access to affordable hearing ... 30 million hard of hearing individuals in the United States. , “For the ...
(Date:2/9/2016)... ... February 09, 2016 , ... IsoComforter, Inc., one of the ... newly designed, innovative shoulder wrap. The newly designed shoulder wrap has been ... arm and shoulder to promote faster healing. It is highly recommended for arm ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb.8, 2016 Cardiac Assist ... Summary GlobalData,s Medical Devices sector report, " ... 2015 " provides an overview of Cardiac Assist ... provides comprehensive information on the pipeline products with ... of development. The report reviews major players involved ...
(Date:2/8/2016)... Devices - Medical Devices Pipeline Assessment, 2015 Summary ... Medical Devices Pipeline Assessment, 2015" provides an overview of ... This report is prepared using data sourced from in-house ... industry experts. *Note: Certain sections in the report ... and relevance of data in relation to the equipment ...
(Date:2/8/2016)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... and year-end 2015 results after the Nasdaq market closes ... a live conference call and webcast to discuss its ... February 11, 2016 at 4:30 p.m. Eastern Time (1:30 ... http://www.neurocrine.com . --> Participants can access ...
Breaking Medicine Technology: