Navigation Links
Gene Tied to Post-Op Delirium in Elderly
Date:8/24/2007

APOE e4 variant has also been linked to Alzheimer's, researchers note

FRIDAY, Aug. 24 (HealthDay News) -- Elderly people with the apolipoprotein E (APOE) e4 gene variant -- associated with an increased risk of late-onset Alzheimer's disease and other types of dementia -- are more likely to develop postoperative delirium after major surgery than those without the gene variant, a U.S. study finds.

Researchers at the University of California, San Francisco, analyzed 190 elderly patients, average age 72.5.

They found that about 28 percent of those with APOE e4 developed postoperative delirium, compared with 11 percent of those without APOE e4.

After adjusting for a number of factors -- including older age and previous central nervous system disorders -- the researchers concluded that patients with the APOE e4 gene variant were nearly four times more likely to develop postoperative delirium.

Overall, about 15 percent of the patients developed postoperative delirium on the first and second days after surgery.

Postoperative delirium has been linked with increased rates of in-hospital death and nursing home placement, the researchers noted.

"Despite this prevalence and clinical importance, no specific causative factor has been identified," study author Dr. Jacqueline M. Leung said in a prepared statement.

"Our results suggest that genetic predisposition plays a role and may interact with anesthetic/surgical factors contributing to the development of early postoperative delirium," said Leung.

The findings were published in the September issue of the journal Anesthesiology.

Leung said more studies are needed to further investigate the APOE e4-postoperative delirium link and to explore whether people with APOE e4 who develop postoperative delirium are at increased risk for later cognitive impairment.

More information

The U.S. National Institute
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Sleep apnoea increases post-operative risks
2. Surgeries Performed In The Morning Have Less Post-Op Complications
3. Post-Operative Pain in Breast Cancer Surgery
4. Post-operated Cataract Patients Lose Eyes
5. Shorter Post-Operative Recovery Stay After Tonsillectomy for Kids Safe, Cost-Efficient
6. Delirium linked to death
7. Non ventilated patients in intensive care may suffer from delirium
8. Relationship Between Delirium and Dementia
9. Better Care Could Prevent One Third of Delirium Cases
10. Depression a possible danger in elderly
11. More Elderly Take Inappropriate and Harmful Medications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
(Date:12/25/2014)... 2014 AngelWeddingDress.com tries its best to ... realm. Today, the business has introduced its new collection ... dress promotion. , The new prom outfits are guaranteed ... dress lover. They are specially designed for 2015. Anyone ... dresses should visit its website before Jan. 26, 2015, ...
(Date:12/25/2014)... 2014 Plugin creators from Pixel Film ... fully customizable business presentation tool made specifically for ... 5k business tool, users can now display their stats ... Pixel Film Studios. “ProFire 5k gives users a multiple ... professionalism to a presentation” , Pixel Film Studios takes ...
Breaking Medicine News(10 mins):Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2
... Flexibility exercises belong in cardiovascular workout, experts say , FRIDAY, ... reach for your toes. If you can get your fingers ... a sign that your arteries are flexible, researchers say. ... as defined by how far you can reach while sitting ...
... BOSTON, Oct. 9 The International Medical Interpreters Association ... Continuing Education Units (CEUs) for medical interpreters, in all ... step to professionalize medical interpreters. "Being able to attend ... not only to keep up with the developments in ...
... Calif., Oct. 9 The outcome of the current ... Americans need to get healthier. From childhood obesity to ... the U.S. have been confronted with the consequences of ... from the healthcare crisis, it,s that over-emphasizing one part ...
... Calls for Reform that Eliminates Wasteful Government Procedures ... Harrison, CEO and Founder of The SCOOTER Store, is outraged ... Human Services (HHS) Inspector General,s report was recently cited during ... medical equipment to Medicare beneficiaries. , In a report that ...
... Octomom ... Kate Gosselin ... the recent embryo mix-up ... treatments and making national headlines. But, much to the ... that are actually preventable - something starting to make ... education outreach program, Manicures & Martinis, continues to sweep ...
... ... skin-friendly, flexible, and tacky adhesive. A way to make respirators universally fit faces, providing ... . Pricing and product details may be found on our website. , ... Baxter, MN (PRWEB) October 9, ...
Cached Medicine News:Health News:Stretching Test May Reveal Arterial Stiffness 2Health News:IMIA Sets Continuing Education Standards for Medical Interpreters Worldwide 2Health News:IMIA Sets Continuing Education Standards for Medical Interpreters Worldwide 3Health News:The Holistic Health Show Offers Relief for Healthcare Crisis 2Health News:SCOOTER Store CEO Outraged: Flawed Data Used by Fox News Channel to Wrongly Chastise Medical Suppliers 2Health News:Certain Types of Infertility Are Preventable 2Health News:Certain Types of Infertility Are Preventable 3Health News:Breathe Safely, LLC: Making Respirators 270% More Effective 2
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)...   TRU-D SmartUVC LLC, producers of the ... today that the General Services Administration has awarded the ... This newly formed agreement will allow TRU-D ... purchasers, including Department of Veteran Affairs and Department of ... purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... , Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... the treatment and management of epilepsy, today announced it will ... Conference on Wednesday, January 14, 2015, in San ... President and Chief Executive Officer, will speak at 11:00 AM ... be accessed by clicking on the Investor Relations link on ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... April 27 SI-BONE, Inc. ( Cupertino, California ), ... minimally invasive surgical (MIS) device to treat the sacroiliac (SI) joint ... at upcoming 2010 minimally invasive spine surgery meetings. , ... SI-BONE has been working with ...
... CareFusion Corporation (NYSE: CFN ) today announced plans to release third ... close of trading on the New York Stock Exchange. , ... The company will host a webcast and conference call on May 6 ... to discuss the results for its third quarter, ended on March 31, 2010 ...
Cached Medicine Technology:iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 2iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 3iFuse Implant System(TM) to be Presented at Leading Minimally Invasive Spine Surgical Meetings 4CareFusion Will Host an Earnings Conference Call on May 6 to Discuss the Results for the Third Quarter of Fiscal 2010 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: