Navigation Links
Gene Tied to Common Childhood Language Disorder
Date:11/5/2008

The gene has also been implicated in autism, researchers say

WEDNESDAY, Nov. 5 (HealthDay News) -- British researchers have identified the first gene to be associated with a common childhood language disorder.

Variants of the CNTNAP2 gene are associated with the disorder known as specific language impairment (SLI) -- the unexplained difficulty with language that can involve repetition of nonsense words, the researchers said.

The gene has also been implicated in autism and could represent a genetic link between the two disorders, the scientists said.

But the fact that this gene is also linked to other neurological conditions such as autism, epilepsy, schizophrenia and Tourette's syndrome means it may not be unique to language, but to the early development of cognitive function, said Rajesh Miranda, associate professor of neuroscience and experimental therapeutics at Texas A&M Health Science Center College of Medicine.

No one knows exactly how this gene may be affecting language.

"What skill in language-impaired children is this gene affecting?" said Dr. Karin Stromswold, author of an editorial accompanying the paper in the Nov. 6 issue of the New England Journal of Medicine. "There are a lot of reasons you can be language-impaired, excluding hearing loss and mental retardation."

Many children with common language impairment also have motor impairment, so the gene could actually be affecting either core language or motor involvement, said Stromswold, a professor of psychology and member of the Rutgers University Center for Cognitive Science, in New Brunswick, N.J.

An estimated seven percent of pre-school children have SLI, according to background information in the study.

Scientists had previously identified mutations in a gene known as FOXP2 as involved in speech disorders in one family.

"FOXP2 is the strongest gene candidate for language but the mutation is only seen in a small number of people, just one family, and that family also has mental retardation and other issues," Miranda said.

The FOXP2 gene is also active in animals such as mice, birds and primates that obviously don't have speech problems, Miranda said.

The authors of the new study, from the Wellcome Trust Centre for Human Genetics at the University of Oxford, screened this gene and found that one of the other genes it interacts with is called CNTNAP2. An analysis of CNTNAP2 function in 184 families with common language impairments found that children with certain forms of the gene had language deficits, notably nonsense-word repetition.

The findings seem to raise more questions than they answer, but hopefully they provide a gateway for further discoveries, experts said.

"A lot of times the clues to the basis of a disease come from very small groups," said Miranda. "You find one family that clues you into the process, but then you have to work through the process."

More information

The American Speech-Language-Hearing Association has more on language development.



SOURCES: Karin Stromswold, M.D., Ph.D., professor, psychology and member, Center for Cognitive Science, Rutgers University, New Brunswick, N.J.; Rajesh Miranda, Ph.D., associate professor, neuroscience and experimental therapeutics, Texas A&M Health Science Center College of Medicine; Nov. 6, 2008, New England Journal of Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UK junior doctors gaining less experience of common procedures
2. New insights into common knee injuries
3. High and mighty: first common height gene identified by researchers behind obesity gene finding
4. Figure Skater Peggy Fleming, HealthSaver Says: Take Pains For Back Strains, 2nd Most Common Doctor Complaint
5. Exelixis Commences Public Offering of Common Stock
6. Common misdiagnosis: most women believe they have a yeast infection when they dont
7. Business Executives Discuss National Health Care Reform at Conference Sponsored by The Century Foundation, with Support from The Commonwealth Fund, and AARP
8. New Expert Report Dispels Common Myths About Aspartame
9. Common Foot Myths Trip Us Up
10. AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange
11. Allergy-Induced Asthma More Common in Affluent Countries
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Tied to Common Childhood Language Disorder
(Date:2/12/2016)... ... ... CDRH Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. ... “Those who don’t learn from history are doomed to repeat it.” , An analysis of ... year. But that takes time. , Take a close look at the warning letters ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... firm announced that nominations have closed for the ISE Southeast Awards 2016. Finalists ... be announced at the ISE® Southeast Executive Forum and Awards Gala on March ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a ... initiating a charity drive that will raise funds earmarked to purchase computers and software ... Elementary School. , “My school is in a low-income area and has more than ...
(Date:2/12/2016)... ... 12, 2016 , ... Donor Network West, the organ procurement organization that heals ... with San Ramon Regional Medical Center. Under the collaboration, the first of its kind, ... accommodate a more certain time frame for donor families for the recovery of organs. ...
(Date:2/12/2016)... ... 12, 2016 , ... Nearly every health website and vision ... articles generally list between five and 15 foods that should be consumed regularly ... of these lists and believes that nutritious eye healthy foods are extremely important, ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Ungarn, February 12, 2016 /PRNewswire/ ... Medizintechnikunternehmen, das sich auf den ungedeckten medizinischen ... heute positive Ergebnisse seines klinischen Forschungsprogramms bekannt. ... Asthma-Patienten beschäftigt, ergab Verbesserungen ihrer respiratorischen Funktionen ... Indiso ltd , ein Medizintechnikunternehmen, das sich ...
(Date:2/11/2016)... 11, 2016 Stem cells are primitive cells ... self-renewal and the capacity to differentiate into mature cell ... as the first mouse embryonic stem cells were derived ... 1995 that the first culturing of embryonic stem cells ... not produced until 2006 As a result of these ...
(Date:2/11/2016)... , Feb. 11, 2016  Walgreens has committed ... 39 states and Washington, D.C. as ... move that was commended by shareholder advocacy organization As You ... As You Sow. "Many people hold on to unneeded drugs ... can have tragic consequences." --> Conrad MacKerron ...
Breaking Medicine Technology: