Navigation Links
Gene Therapy in Rats Reduces Cocaine Use
Date:4/18/2008

Boosting brain's dopamine receptors could lead to treatments for other addictions as well

FRIDAY, April 18 (HealthDay News) -- Using gene therapy to increase the level of dopamine -- a pleasure-related chemical -- receptors in rats' brains reduced their desire for cocaine by 75 percent, U.S. researchers say.

Previous research by the same team at the U.S. Department of Energy's Brookhaven National Laboratory, in Upton, N.Y., found that increasing the level of dopamine receptors reduced rats' desire for alcohol.

"By increasing dopamine D2 receptor levels, we saw a dramatic drop in these rats' interest in cocaine. This provides new evidence that low levels of dopamine D2 receptors may play an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential direction for addiction therapies," study lead author Panayotis (Peter) Thanos, a neuroscientist with the Brookhaven Lab and the National Institute on Alcohol Abuse and Alcoholism Laboratory of Neuroimaging, said in a prepared statement.

The study was published online April 16 in the journal Synapse and was expected to be published in the July print edition of the journal.

D2 receptors receive signals triggered by dopamine, a neurotransmitter needed to experience feelings of pleasure and reward. Without these receptors, the brain's pleasure response is blunted, according to background information in the study.

Previous research showed that chronic alcohol and drug abuse increases dopamine production. However, long-term substance abuse depletes the brain's D2 receptors and rewires the brain so that normal pleasurable activities no longer stimulate these pathways. As a result, alcohol and/or drugs are the only way to feel pleasure.

The Brookhaven Lab studies suggest that increasing levels of D2 receptors in the brain could help treat addiction to alcohol, cocaine and other drugs.

More information

The U.S. National Institute on Drug Abuse has more about drug abuse and addiction.



-- Robert Preidt



SOURCE: Brookhaven National Laboratory, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... ... Talented host, actor Rob Lowe, is introducing a segment ... of "Success Files," which is an award-winning educational program broadcasted on PBS Member ... with passion and integrity. , Sciatica occurs when the sciatic nerve in the ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s ... design of the shoulder pad. The shoulder pad provides optimal support and full ... while using cold therapy. By utilizing ice and water that is circulated from an ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... PARK, Calif. , Oct. 11, 2017  BioPharmX ... national scientific team that developed an innovative way to ... quantity of the delivery of new drugs. ... 2017 Fall Clinical Dermatology Conference will show how researchers ... General Hospital, Harvard Medical School used a suite of ...
(Date:10/11/2017)... 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... in Las Piedras, Puerto Rico , ... Following a ... sustained minor structural damage, temporary loss of power and ... been completed, manufacturing operations have resumed, and the company ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
Breaking Medicine Technology: