Navigation Links
Gene Therapy in Rats Reduces Cocaine Use
Date:4/18/2008

Boosting brain's dopamine receptors could lead to treatments for other addictions as well

FRIDAY, April 18 (HealthDay News) -- Using gene therapy to increase the level of dopamine -- a pleasure-related chemical -- receptors in rats' brains reduced their desire for cocaine by 75 percent, U.S. researchers say.

Previous research by the same team at the U.S. Department of Energy's Brookhaven National Laboratory, in Upton, N.Y., found that increasing the level of dopamine receptors reduced rats' desire for alcohol.

"By increasing dopamine D2 receptor levels, we saw a dramatic drop in these rats' interest in cocaine. This provides new evidence that low levels of dopamine D2 receptors may play an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential direction for addiction therapies," study lead author Panayotis (Peter) Thanos, a neuroscientist with the Brookhaven Lab and the National Institute on Alcohol Abuse and Alcoholism Laboratory of Neuroimaging, said in a prepared statement.

The study was published online April 16 in the journal Synapse and was expected to be published in the July print edition of the journal.

D2 receptors receive signals triggered by dopamine, a neurotransmitter needed to experience feelings of pleasure and reward. Without these receptors, the brain's pleasure response is blunted, according to background information in the study.

Previous research showed that chronic alcohol and drug abuse increases dopamine production. However, long-term substance abuse depletes the brain's D2 receptors and rewires the brain so that normal pleasurable activities no longer stimulate these pathways. As a result, alcohol and/or drugs are the only way to feel pleasure.

The Brookhaven Lab studies suggest that increasing levels of D2 receptors in the brain could help treat addiction to alcohol, cocaine and other drugs.

More information

The U.S. National Institute on Drug Abuse has more about drug abuse and addiction.



-- Robert Preidt



SOURCE: Brookhaven National Laboratory, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... 02, 2016 , ... Mediaplanet is proud to announce the ... the innovative treatments, therapeutic technologies, and revolutionized nutrition that are helping patients and ... 6 years in the last 3 decades,” says Dr. Valentine Fuster, a world-renowned ...
(Date:12/2/2016)... ... December 02, 2016 , ... Universal ... systems and the first company to offer robotic imaging to veterinary medicine ... tradeshow booth # 941 for the American Association of Equine Practitioners 62nd Annual ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... Yisrayl Hawkins, ... delves into how this current generation fits into Bible Prophecy. Yisrayl says this generation, ... facts pointing to this conclusion, showing how the details line up exactly with Bible ...
(Date:12/2/2016)... ... December 02, 2016 , ... On November 24th, 2016, ... from eight different sites throughout Miami-Dade and Broward counties. This is the largest ... hard on Thanksgiving morning by putting together individual meals via assembly lines and ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 creative ... National Family Partnership and the Drug Enforcement Administration as part of the National Red ... 10 winning schools who decorated their campuses with this year’s Red Ribbon Week theme: ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Dec. 2, 2016  PipelineRx, a leading medication management ... offering demonstrations of its SaaS-based telepharmacy platform, ... Pharmacists 2016 Midyear Clinical Meeting and Exhibition, December ... With nearly 300 hospital clients nationally, the Company ... designed to dramatically improve pharmacy operations, enhance patient ...
(Date:12/2/2016)... Va. , Dec. 2, 2016  The ... by the Academy of Managed Care Pharmacy (AMCP), ... organizations can better address the opioid addiction crisis, ... Assisted Therapies (MAT). ATAG,s newly released ... Improving Access to Naloxone," addresses many issues around ...
(Date:12/2/2016)... bioLytical Laboratories, ein Weltführer bei schnellen Tests für ... Apothekenbundes von Kenia eingeführt. Continue Reading ... ... Test! (PRNewsFoto/bioLytical Laboratories) ... http://photos.prnewswire.com/prnh/20161201/444905 ) bioLytical wurde durch die ...
Breaking Medicine Technology: