Navigation Links
Gene Therapy in Rats Reduces Cocaine Use
Date:4/18/2008

Boosting brain's dopamine receptors could lead to treatments for other addictions as well

FRIDAY, April 18 (HealthDay News) -- Using gene therapy to increase the level of dopamine -- a pleasure-related chemical -- receptors in rats' brains reduced their desire for cocaine by 75 percent, U.S. researchers say.

Previous research by the same team at the U.S. Department of Energy's Brookhaven National Laboratory, in Upton, N.Y., found that increasing the level of dopamine receptors reduced rats' desire for alcohol.

"By increasing dopamine D2 receptor levels, we saw a dramatic drop in these rats' interest in cocaine. This provides new evidence that low levels of dopamine D2 receptors may play an important role in not just alcoholism but in cocaine abuse as well. It also shows a potential direction for addiction therapies," study lead author Panayotis (Peter) Thanos, a neuroscientist with the Brookhaven Lab and the National Institute on Alcohol Abuse and Alcoholism Laboratory of Neuroimaging, said in a prepared statement.

The study was published online April 16 in the journal Synapse and was expected to be published in the July print edition of the journal.

D2 receptors receive signals triggered by dopamine, a neurotransmitter needed to experience feelings of pleasure and reward. Without these receptors, the brain's pleasure response is blunted, according to background information in the study.

Previous research showed that chronic alcohol and drug abuse increases dopamine production. However, long-term substance abuse depletes the brain's D2 receptors and rewires the brain so that normal pleasurable activities no longer stimulate these pathways. As a result, alcohol and/or drugs are the only way to feel pleasure.

The Brookhaven Lab studies suggest that increasing levels of D2 receptors in the brain could help treat addiction to alcohol, cocaine and other drugs.

More information

The U.S. National Institute on Drug Abuse has more about drug abuse and addiction.



-- Robert Preidt



SOURCE: Brookhaven National Laboratory, news release, April 16, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts ... Washington, D.C., for the 49th Congress of the International Society of Paediatric Oncology ... of the Center for Cancer and Blood Disorders at Children’s National, and ...
(Date:10/12/2017)... ... October 12, 2017 , ... Vohra Chief Medical ... to physician colleagues, skilled nursing facility medical directors and other clinicians at various ... Wound Care." , "At many of these conferences we get to educate other ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Israel and NEW YORK , Sept. 27, ... with mobile health and big data solutions, today announced that its MyDario ... Please check your local TV listings for when The Dr. Oz Show ... ... season this month. ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
Breaking Medicine Technology: