Navigation Links
Gene Therapy for HIV Inches Forward
Date:6/16/2010

Viable treatment is still a long way off, researchers say

WEDNESDAY, June 16 (HealthDay News) -- Researchers report they've moved a step closer to treating HIV patients with gene therapy that could potentially one day keep the AIDS-causing virus at bay.

The study, published in the June 16 issue of the journal Science Translational Medicine, only looked at one step of the gene therapy process, and there's no guarantee that genetically manipulating a patient's own cells will succeed or work better than existing drug therapies.

Still, "we demonstrated that we could make this happen," said study lead author David L. DiGiusto, a biologist and immunologist at City of Hope, a hospital and research center in Duarte, Calif. And the research took place in people, not in test tubes.

Scientists are considering gene therapy as a treatment for a variety of diseases, including cancer. One approach involves inserting engineered genes into the body to change its response to illness.

In the new study, researchers genetically manipulated blood cells to resist HIV and inserted them into four HIV-positive patients who had lymphoma, a blood cancer.

The patients' healthy blood cells had been stored earlier and were being transplanted to treat the lymphoma.

Ideally, the cells would multiply and fight off HIV infection. In that case, "the virus has nowhere to grow, no way to expand in the patient," DiGiusto said.

At this early point in the research process, however, the goal was to see if the implanted cells would survive. They did, remaining in the bloodstreams of the subjects for two years.

In the next phases of research, scientists will try to implant enough genetically engineered cells to actually boost the body's ability to fight off HIV, DiGiusto said.

Plenty of caveats still exist. The research, as DiGiusto said, is experimental. And there's the matter of cost: He estimated that the price for gene therapy treatment for HIV patients could run about as much as a bone marrow transplant. Those cost about $100,000.

On the other hand, gene therapy has the potential to free HIV patients from a lifetime of taking medications that may fail to work, especially if the virus develops immunity to them, said David V. Schaffer, co-director of the Berkeley Stem Cell Center at the University of California at Berkeley and co-author of a commentary accompanying DiGiusto's study.

Over time, the savings on medications could outweigh the cost of the gene therapy, he noted.

The treatment wouldn't necessarily be a cure because the virus would remain in the body. Still, it could create a situation "where HIV is present but at levels that are too low to detect and don't cause AIDS," Schaffer said.

More information

For more about gene therapy, visit the U.S. National Library of Medicine.



SOURCES: David L. DiGiusto, Ph.D., director, Analytical Cytometry Core Facility, City of Hope, Duarte, Calif.; David V. Schaffer, Ph.D., co-director, Berkeley Stem Cell Center, University of California at Berkeley; June 16, 2010, Science Translational Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gino Tutera, M.D., F.A.C.O.G. Brings SottoPelle Therapy to Middle Tennessee, Opens Practice in Nashville Medical District
2. Combined BRAF-targeted and immunotherapy shows promise for melanoma treatment
3. Longer Antiviral Therapy Reduces Lung Transplant Complications
4. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
5. New promising therapy against systemic sclerosis
6. CPAP therapy provides a memory boost for adults with sleep apnea
7. Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs
8. Experimental targeted therapy shows early promise against medulloblastomas
9. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
10. Targeted Therapy Shows Promise Against Deadly Brain Cancer
11. Ft Myers Plastic Surgeon, Dr. Robert J. Brueck MD, Performs Facial Rejuvenation Using Innovative Stem Cell Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Therapy for HIV Inches Forward
(Date:4/28/2016)... ... 2016 , ... One way to ignore solid evidence is to dismiss research ... toss the baby out with the bathwater when we ignore all studies because some ... and otherwise making better use of education policy research. , “When readers heed basic ...
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... USA Medical Card reminds us that May ... (CDC), a stroke is the fourth leading cause of death in the United States; someone ... almost a quarter of them in individuals under 65 years old. A stroke is ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... today announced a new Residency Education & Collaboration Platform for hospitals and ... resources, and a host of collaboration tools designed to improve patient outcomes ...
(Date:4/28/2016)... ... 2016 , ... A first-time look at workers’ compensation claims in Kentucky found ... Compensation Research Institute (WCRI) announced, and that costs per claim were stable between ... Edition , found that indemnity costs per claim and benefit delivery expenses per claim ...
(Date:4/28/2016)... , ... April 28, 2016 , ... ... has partnered with Community Oncology Pharmacy Association (COPA) to develop a comprehensive Specialty ... of oncology by introducing an accreditation distinction. ACHC provides a wide range of ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... April 27, 2016 Oasmia ... developer of a new generation of drugs within ... survival results for Paclical/Apealea in the Phase III ... with epithelial ovarian cancer. These preliminary results showed ... combination with carboplatin versus Taxol in combination with ...
(Date:4/26/2016)... , April 26, 2016 Diplomat Pharmacy, ... of Jennifer Hagerman , Pharm D., to Vice ... growing role at Diplomat, Hagerman will continue to lead ... company that delivers custom education and training to Diplomat ... specialty pharmacy industry. Diplomat University also houses the quality ...
(Date:4/26/2016)... , April 26, 2016 Research ... and Credit Risk Analysis of the Biological Medicine Industry ... This comprehensive report analyzes the financial assessment and credit ... China . The report provides readers with an ... all market participants should be aware of. It considers ...
Breaking Medicine Technology: