Navigation Links
Gene Therapy for HIV Inches Forward

Viable treatment is still a long way off, researchers say

WEDNESDAY, June 16 (HealthDay News) -- Researchers report they've moved a step closer to treating HIV patients with gene therapy that could potentially one day keep the AIDS-causing virus at bay.

The study, published in the June 16 issue of the journal Science Translational Medicine, only looked at one step of the gene therapy process, and there's no guarantee that genetically manipulating a patient's own cells will succeed or work better than existing drug therapies.

Still, "we demonstrated that we could make this happen," said study lead author David L. DiGiusto, a biologist and immunologist at City of Hope, a hospital and research center in Duarte, Calif. And the research took place in people, not in test tubes.

Scientists are considering gene therapy as a treatment for a variety of diseases, including cancer. One approach involves inserting engineered genes into the body to change its response to illness.

In the new study, researchers genetically manipulated blood cells to resist HIV and inserted them into four HIV-positive patients who had lymphoma, a blood cancer.

The patients' healthy blood cells had been stored earlier and were being transplanted to treat the lymphoma.

Ideally, the cells would multiply and fight off HIV infection. In that case, "the virus has nowhere to grow, no way to expand in the patient," DiGiusto said.

At this early point in the research process, however, the goal was to see if the implanted cells would survive. They did, remaining in the bloodstreams of the subjects for two years.

In the next phases of research, scientists will try to implant enough genetically engineered cells to actually boost the body's ability to fight off HIV, DiGiusto said.

Plenty of caveats still exist. The research, as DiGiusto said, is experimental. And there's the matter of cost: He estimated that the price for gene therapy treatment for HIV patients could run about as much as a bone marrow transplant. Those cost about $100,000.

On the other hand, gene therapy has the potential to free HIV patients from a lifetime of taking medications that may fail to work, especially if the virus develops immunity to them, said David V. Schaffer, co-director of the Berkeley Stem Cell Center at the University of California at Berkeley and co-author of a commentary accompanying DiGiusto's study.

Over time, the savings on medications could outweigh the cost of the gene therapy, he noted.

The treatment wouldn't necessarily be a cure because the virus would remain in the body. Still, it could create a situation "where HIV is present but at levels that are too low to detect and don't cause AIDS," Schaffer said.

More information

For more about gene therapy, visit the U.S. National Library of Medicine.

SOURCES: David L. DiGiusto, Ph.D., director, Analytical Cytometry Core Facility, City of Hope, Duarte, Calif.; David V. Schaffer, Ph.D., co-director, Berkeley Stem Cell Center, University of California at Berkeley; June 16, 2010, Science Translational Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Gino Tutera, M.D., F.A.C.O.G. Brings SottoPelle Therapy to Middle Tennessee, Opens Practice in Nashville Medical District
2. Combined BRAF-targeted and immunotherapy shows promise for melanoma treatment
3. Longer Antiviral Therapy Reduces Lung Transplant Complications
4. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
5. New promising therapy against systemic sclerosis
6. CPAP therapy provides a memory boost for adults with sleep apnea
7. Updated HIV therapy guidelines would reduce risk of transmission, save lives, billions in costs
8. Experimental targeted therapy shows early promise against medulloblastomas
9. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
10. Targeted Therapy Shows Promise Against Deadly Brain Cancer
11. Ft Myers Plastic Surgeon, Dr. Robert J. Brueck MD, Performs Facial Rejuvenation Using Innovative Stem Cell Therapy
Post Your Comments:
Related Image:
Gene Therapy for HIV Inches Forward
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, ... Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. ... skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Grove Investment Group (TGIG), has initiated cultivation and processing operations at its production ... and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: