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Gene Therapy Shows Potential Against Heart Failure
Date:11/16/2010

For this phase 2 study, 39 patients with advanced heart failure were randomly chosen to receive either the gene therapy (through cardiac catheterization) or a placebo.

At both six months and a year later, the patients who had received the new gene saw their risk for death, cardiac transplantation, worsening heart failure and hospitalization decline by half.

Results were even more heartening at higher doses, where participants had an 88 percent decrease in risk for death, cardiac transplant, hospitalizations and other outcomes, the study authors said.

Redberg cautioned that the study was still preliminary and "requires more investigation."

And research presented at meetings isn't subjected to the same level of scrutiny as studies published in peer-reviewed journals.

The study was funded by the Celladon Corp. of La Jolla, Calif.

More information

The American Heart Association has more on heart failure.

SOURCES: Rita Redberg, M.D., professor of medicine, University of California, San Francisco, and spokeswoman, American Heart Association; Robert Eckel, M.D., professor of medicine, University of Colorado Denver, and past president, American Heart Association; study abstract, Nov. 14, 2010, American Heart Association annual meeting, Chicago


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