Navigation Links
Gene Therapy Offers Hope Against Inherited Blindness
Date:8/12/2009

Injection under retina may allow increased light sensitivity, research suggests

WEDNESDAY, Aug. 12 (HealthDay News) -- Gene therapy for an inherited form of blindness shows promise, a U.S. study shows.

The phase I trial included three patients, aged 22, 24 and 25, with a form of Leber congenital amaurosis caused by mutations in the RPE65 gene. Proper functioning of this gene is required for the production of a retina-specific form of vitamin A that's required for light-sensitive photoreceptor cells to function.

In the study, researchers injected healthy copies of the RPE65 gene under the retina in the eyes of the participants, who'd been legally blind since birth. One year after treatment, the patients could detect very dim lights that they weren't able to see prior to treatment. The results provide evidence that the newly introduced RPE65 gene is functional and is increasing the light sensitivity of the retina, according to the researchers.

The findings appear in the August online edition of Human Gene Therapy and in a letter to the editor in the Aug. 13 issue of the New England Journal of Medicine.

"At one year, we have now found that the RPE65 gene therapy appears to be safe and leads to a stable visual improvement in the patients studied. We are cautiously optimistic about these results and look forward to additional reports that address the key issues of safety and effectiveness," study author Artur V. Cideciyan, a research associate professor of ophthalmology at the University of Pennsylvania, said in a news release from the National Eye Institute.

"These results are very significant because they represent one of the first steps toward the clinical use of gene therapy for an inherited form of blindness. I anticipate that it is only a matter of time before similar techniques will be applied to other genetic diseases affecting vision," Dr. Paul A. Sieving, director of the U.S. National Eye Institute, said in the news release.

More information

The Foundation Fighting Blindness has more about Leber congenital amaurosis.



-- Robert Preidt



SOURCE: U.S. National Eye Institute, news release, Aug. 12, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ProCure and INTEGRIS Choose Elekta for Proton Therapy and Cancer Centers
2. Folk Medicine Therapy May Prevent Alcoholic Relapse
3. Computer system improves pain therapy for cancer patients
4. Jefferson Headache Center study shows novel, orally inhaled migraine therapy effective
5. APTA Calls For CMS and Congressional Action to Prohibit Unqualified Personnel From Providing Physical Therapy Services
6. Hollins Communications Research Institute Announces More Stuttering Therapy Scholarships
7. In U.S., No Comeback Seen for Hormone Therapy
8. The Sloane Clinic pioneers Ultherapy in Singapore
9. State Regulation of Massage Therapy Will Improve Public Health, Safety
10. Londons Barts Hospital Selects Varian Equipment to Offer Advanced Radiotherapy to More Cancer Patients
11. Omaha School of Massage Therapy Adds Healthcare Programs, Joins Herzing University, and Changes Name
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Therapy Offers Hope Against Inherited Blindness 
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between Goodwill® and Roadie, ... use or need, from clothes to couches to dressers and bicycles. Roadie — the ... to the nearest Goodwill donation center through February 28th. , “January is an ...
(Date:1/20/2017)... ... 2017 , ... Bionic Sports Nutrition LLC, an American company devoted to developing ... successful January ECRM Trade Show in Hilton Head, SC. , Bionic Sports Nutrition ... provide its products to all clients at reasonable prices. At the ECRM trade show, ...
(Date:1/20/2017)... ... January 20, 2017 , ... Michael and Betsy Brauser celebrated ... Institute. For Betsy, the clinical trial has been life-saving as she has been ... , Betsy Brauser was diagnosed with ovarian cancer in 2009. She underwent standard ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and ... out for each of his children. “The Angel” is the creation of published author, ... New York City, and impassioned writer. , When asked of her new book, Marjorie ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas in ... where she works in a daycare and looks for inspiration in the local coffee ... Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017 The global immunomodulators market is ... according to a new study by Grand View ... predominantly driven by high R&D investments employed by ... of new and therapeutically advanced drugs. This is ... an unprecedented rate into the immunomodulators market hence ...
(Date:1/19/2017)... 2017 Conference Call and Webcast to Follow ... it will release results for the fourth quarter of 2016 on ... ... call at 4:30 PM ET on Wednesday, February 15, 2017, during ... financial results and other corporate activities. To participate in the conference ...
(Date:1/19/2017)... 19, 2017  Stealth BioTherapeutics Inc. ( Stealth ), ... dysfunction, today announced new additions to its senior leadership ... Medical Officer, and Daniel Geffken as interim ... Jim Carr , Pharm.D. has been promoted to Chief ... to welcome Doug and Daniel to our management team, ...
Breaking Medicine Technology: