Navigation Links
Gene Therapy Offers Hope Against Inherited Blindness

Injection under retina may allow increased light sensitivity, research suggests

WEDNESDAY, Aug. 12 (HealthDay News) -- Gene therapy for an inherited form of blindness shows promise, a U.S. study shows.

The phase I trial included three patients, aged 22, 24 and 25, with a form of Leber congenital amaurosis caused by mutations in the RPE65 gene. Proper functioning of this gene is required for the production of a retina-specific form of vitamin A that's required for light-sensitive photoreceptor cells to function.

In the study, researchers injected healthy copies of the RPE65 gene under the retina in the eyes of the participants, who'd been legally blind since birth. One year after treatment, the patients could detect very dim lights that they weren't able to see prior to treatment. The results provide evidence that the newly introduced RPE65 gene is functional and is increasing the light sensitivity of the retina, according to the researchers.

The findings appear in the August online edition of Human Gene Therapy and in a letter to the editor in the Aug. 13 issue of the New England Journal of Medicine.

"At one year, we have now found that the RPE65 gene therapy appears to be safe and leads to a stable visual improvement in the patients studied. We are cautiously optimistic about these results and look forward to additional reports that address the key issues of safety and effectiveness," study author Artur V. Cideciyan, a research associate professor of ophthalmology at the University of Pennsylvania, said in a news release from the National Eye Institute.

"These results are very significant because they represent one of the first steps toward the clinical use of gene therapy for an inherited form of blindness. I anticipate that it is only a matter of time before similar techniques will be applied to other genetic diseases affecting vision," Dr. Paul A. Sieving, director of the U.S. National Eye Institute, said in the news release.

More information

The Foundation Fighting Blindness has more about Leber congenital amaurosis.

-- Robert Preidt

SOURCE: U.S. National Eye Institute, news release, Aug. 12, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. ProCure and INTEGRIS Choose Elekta for Proton Therapy and Cancer Centers
2. Folk Medicine Therapy May Prevent Alcoholic Relapse
3. Computer system improves pain therapy for cancer patients
4. Jefferson Headache Center study shows novel, orally inhaled migraine therapy effective
5. APTA Calls For CMS and Congressional Action to Prohibit Unqualified Personnel From Providing Physical Therapy Services
6. Hollins Communications Research Institute Announces More Stuttering Therapy Scholarships
7. In U.S., No Comeback Seen for Hormone Therapy
8. The Sloane Clinic pioneers Ultherapy in Singapore
9. State Regulation of Massage Therapy Will Improve Public Health, Safety
10. Londons Barts Hospital Selects Varian Equipment to Offer Advanced Radiotherapy to More Cancer Patients
11. Omaha School of Massage Therapy Adds Healthcare Programs, Joins Herzing University, and Changes Name
Post Your Comments:
Related Image:
Gene Therapy Offers Hope Against Inherited Blindness 
(Date:10/13/2015)... , ... October 13, 2015 , ... ProText Kinetic Panel ... . With ProText Kinetic Panel, users can create energetic text animations in any layout ... into the Final Cut Pro X timeline and stylize the text. With intuitive on-screen ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... of IBM software products, introduced a new company, RightSensor™ LLC, an Internet of ... communications capability. RightSensor™ provides a fully-managed approach for customers requiring sensor hardware ...
(Date:10/13/2015)... Hollywood, CA (PRWEB) , ... October 13, 2015 , ... ... published by Medical New Today on September 18, 2015. The research, which was conducted ... by Dr. Wael Sabbah and colleagues, show connections between stress during pregnancy and future ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... A child ... that’s why SmileCareClub , the leading remote invisible aligner system, has joined with ... would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will donate ...
(Date:10/13/2015)... Hills, CA (PRWEB) , ... October 13, 2015 ... ... management and workflow solutions, announced today their Title Sponsorship of Synergy 2015. The ... in Henderson, NV at Green Valley Ranch and will unite customers, partners, WennSoft ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... DUBLIN , Oct. 13 2015 /PRNewswire/ ... announced the addition of the "US ... - 16 Countries (2010-2021)" report to ... has announced the addition of the ... Repair - 16 Countries (2010-2021)" report ...
(Date:10/13/2015)... LAUDERDALE, Fla. , Oct. 13, 2015   ... developer of solutions that aid in the early detection ... has awarded Vigilant,s founder and CEO, Matthew ... the Year Award, which recognizes an entrepreneur who has ... Florida,s life sciences industry in the leadership ...
(Date:10/13/2015)... 13, 2015   Happy Vitals ®, ... home testing kit for breast milk.  The ... an unparalleled, detailed assessment of the nutrition ... carbs and key vitamins—all charted over time ... health tracking.  In addition, Happy Vitals also offers ...
Breaking Medicine Technology: