Navigation Links
Gene Therapy May Ease Rheumatoid Arthritis
Date:2/6/2009

2 women who got injections report reduced pain and swelling

FRIDAY, Feb. 6 (HealthDay News) -- The first evidence that gene therapy can ease symptoms in people with rheumatoid arthritis (RA) has been reported by American and German researchers.

The study included two postmenopausal women with advanced RA. Researchers injected the interleukin-1 receptor antagonist (IL-1Ra) gene into the women's affected joints. IL-1Ra protein blocks the actions of interleukin-1 protein, which plays a role in the breakdown of cartilage that occurs in arthritis patients.

"The idea is that by remaining in place, the new gene can continuously block the action of the interleukin-1 within the joints. In essence, the gene becomes its own little factory, continuously working to alleviate pain and swelling," principal investigator Christopher Evans, director of the Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center in Boston, said in a Harvard Medical School news release.

Four weeks after IL-1Ra was injected into their affected joints, both women reported reduced pain and swelling.

"In one of the two subjects, these effects were dramatic, and the gene-treated joints remained pain-free even though other joints experienced flares," said Evans, who is also a professor of orthopedic surgery at Harvard.

The findings were published in the February issue of the journal Human Gene Therapy. The study received funding from Orthogen, a German biotechnology company.

The study "helps extend gene therapy research to nongenetic, nonlethal diseases," said Evans, who added that arthritis "is a good target for this treatment, because the joint is a closed space into which we can inject genes."

More information

The Arthritis Foundation has more about rheumatoid arthritis.



-- Robert Preidt



SOURCE: Harvard Medical School, news release, Jan. 27, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Therapy May Ease Rheumatoid Arthritis
(Date:3/28/2017)... ... ... Thank you to all who attended Capio Partners Winter 2017 Healthcare Leadership Symposium in ... and offered an opportunity to collaborate and network with healthcare colleagues across the United ... gathered for a lively discussion on trends and issues that healthcare leaders will face ...
(Date:3/28/2017)... ... ... that reveals the mystery of Kevin’s purpose. “A Prophets Bones” is the creation of published ... him that he had neglected to do, but this was from God and there was ... would have felt themselves to be special and better than others due to the fact ...
(Date:3/27/2017)... ... ... New patients who have sleep apnea in Aurora, CO, can now ... Sleep apnea is often left untreated because patients are not familiar with common symptoms ... , Dr. Braasch seeks to raise awareness of sleep apnea in Aurora, CO, and ...
(Date:3/27/2017)... ... March 27, 2017 , ... Drs. Bruce Trimble and Michelle ... requiring a referral. Trimble Dental offers a variety of services to meet each ... Whether patients have discolored, crooked or missing teeth in Eau Claire, WI, Drs. ...
(Date:3/27/2017)... ... ... Drs. Justin Kolnick, Kara Diamond, Randall Barton, Keith Hope and Bilal Chaudhry ... this treatment plays in protecting oral health, along with the benefits of receiving ... a root canal in White Plains, NY or their second location in Mt. Kisco, ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... March 27, 2017  BERG, a biopharmaceutical ... biological research approach, today announced that the ... discovery of new data using a cold-induced ... fat metabolism. Joslin Diabetes Center led the ... platform for analysis of samples.  The findings ...
(Date:3/27/2017)... , March 27, 2017  iCAD (Nasdaq: ... workflow solutions and radiation therapy for the early ... PowerLook® Tomo Detection received Premarket Approval (PMA) from ... Tomo Detection is a first-of-its-kind, concurrent-read computer aided ... is the latest innovation available on the PowerLook® ...
(Date:3/27/2017)...  Impax Laboratories, Inc. (NASDAQ: IPXL)today announced that its ... as Impax,s President and Chief Executive Officer and ... 2017. Mr. Bisaro will succeed J. Kevin Buchi ... Executive Officer since December of 2016. ... Mr. Bisaro, 56, is an accomplished global business leader ...
Breaking Medicine Technology: