Navigation Links
Gene Therapy May Ease Rheumatoid Arthritis

2 women who got injections report reduced pain and swelling

FRIDAY, Feb. 6 (HealthDay News) -- The first evidence that gene therapy can ease symptoms in people with rheumatoid arthritis (RA) has been reported by American and German researchers.

The study included two postmenopausal women with advanced RA. Researchers injected the interleukin-1 receptor antagonist (IL-1Ra) gene into the women's affected joints. IL-1Ra protein blocks the actions of interleukin-1 protein, which plays a role in the breakdown of cartilage that occurs in arthritis patients.

"The idea is that by remaining in place, the new gene can continuously block the action of the interleukin-1 within the joints. In essence, the gene becomes its own little factory, continuously working to alleviate pain and swelling," principal investigator Christopher Evans, director of the Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center in Boston, said in a Harvard Medical School news release.

Four weeks after IL-1Ra was injected into their affected joints, both women reported reduced pain and swelling.

"In one of the two subjects, these effects were dramatic, and the gene-treated joints remained pain-free even though other joints experienced flares," said Evans, who is also a professor of orthopedic surgery at Harvard.

The findings were published in the February issue of the journal Human Gene Therapy. The study received funding from Orthogen, a German biotechnology company.

The study "helps extend gene therapy research to nongenetic, nonlethal diseases," said Evans, who added that arthritis "is a good target for this treatment, because the joint is a closed space into which we can inject genes."

More information

The Arthritis Foundation has more about rheumatoid arthritis.

-- Robert Preidt

SOURCE: Harvard Medical School, news release, Jan. 27, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Vision restoration therapy shown to improve brain activity in brain injured patients
2. HIV therapy in pregnancy-data support WHO recommendations
3. Family-based treatment more effective than supportive psychotherapy in treating bulimia
4. Trial to Test Gene Therapy for Angina in Women
5. One of the Largest Post-WHI Physician Surveys Shows More Education is Needed: Patient Misinformation About Hormone Therapy Remains High
6. Aromatherapy Gift Line Sheds Humorous Light on Modern Therapy
7. Chemotherapy may be culprit for fatigue in breast cancer survivors
8. Atlanta Falcons Physical Therapy Centers Set to Launch This Fall
9. New Drug No Substitute for Standard Blood-Clot Therapy
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Nucletron Announces Management Buy-Out to More Effectively Meet the Demands of Its Customers and the Radiation Therapy Community
Post Your Comments:
Related Image:
Gene Therapy May Ease Rheumatoid Arthritis
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers ... companies have a waiver for care if the client has a cognitive impairment diagnosis. ... pays for care, is often waived, so the benefits from their insurance start immediately,” ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... Del. (PRWEB) , ... October 12, 2017 , ... ... and advisory services for healthcare compliance program management, will showcase a range of ... National Association for Assisted Living (NCAL) Convention and Expo to be held October ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company has developed a ... and regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been ... standard. , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, ... 2017 earnings conference call and webcast on Friday, November ... a.m. (EDT) and ending at approximately 8:30 a.m. (CDT) ... discussing the company,s 2017 financial performance and guidance for ... opportunities, initiatives to enhance operational performance, and long-range financial ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: