Navigation Links
Gene Test May ID Younger Women at Risk for Melanoma

Variation found in more than 40% of females under 50 raises odds almost 4-fold

WEDNESDAY, March 25 (HealthDay News) -- A genetic variation that's associated with a nearly fourfold increased risk of melanoma in women under the age of 50 has been identified by researchers at the New York University School of Medicine.

Identification of this variation in a gene called MDM2 could lead to a screening test to identify women at high risk for the deadly skin cancer.

If confirmed in further studies, the increased risk caused by the MDM2 variation "is higher than a lot of the other clinical factors that we know, such as blistering sunburns, freckling, and family history," study author Dr. David Polsky, an associate professor of dermatology and director of the Pigmented Lesion Section of the dermatology department at NYU School of Medicine, said in a university news release.

"Potentially, we have a genetic test that might identify premenopausal women who are at higher risk for melanoma. And if that's not the case, then we might want to have increased surveillance of those patients including more frequent visits to the doctor, more rigorous teaching of skin self-examination, and other preventive steps," he said.

In their study of 227 melanoma patients, Polsky and colleagues found that more than 40 percent of female patients younger than 50 had the MDM2 genetic variation, compared with about 16 percent of female patients older than 50. The difference in frequency of the genetic variation corresponded to a 3.89-fold increased risk of melanoma among women younger than 50, the researchers said.

The study was published online March 24 and was expected to be in the April 1 print issue of the journal Clinical Cancer Research.

More information

The U.S. National Cancer Institute has more about melanoma.

-- Robert Preidt

SOURCE: New York University Langone Medical Center, news release, March 24, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. NYU study finds new risk factor for melanoma in younger women
2. Band Aid Mini Facelift Developed by Atlanta Plastic Surgeon John L. LeRoy, MD can Help Patients Look Younger for Less Money
3. Younger Women With Breast Cancer Face Added Peril
4. Older Adults Get Drunk Faster Than Younger Drinkers
5. Younger breast cancer patients have greater chance of recurrence
6. Silent Strokes More Common in Younger People Than Thought
7. ER Less Likely to Diagnose Stroke in Younger Folks
8. Study shows younger women with endometrial cancer can safely keep ovaries, avoid early menopause
9. Looking Years Younger, Raising a Few Brows
10. Half of Adults 50 and Younger With Low 10-Year Risk of CVD Have High Lifetime Risk
11. Panic attacks linked to higher risk of heart attacks and heart disease, especially in younger people
Post Your Comments:
Related Image:
Gene Test May ID Younger Women at Risk for Melanoma
(Date:11/26/2015)... ... November 26, 2015 , ... ... to discuss bioavailability and the need to integrate dose form selection in early ... with OBN, the membership organization supporting and bringing together the UK’s emerging life ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... for all, Water For Empowerment ™ attracts volunteers together who want to ... by empowering women as key stakeholders in the process. The non-profit launched its ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , North ... , Sauna accessories help improve the bather experience in the sauna, and the ... for the purist looking for simplicity in design to accessories that encourage a ...
(Date:11/25/2015)... ... ... For the first time, Vitalalert is donating half of its earnings to ... between the two groups began in 2014 with Vitalalert pledging a portion of every ... founded in 1954 and is an international Christian-based health organization whose mission is to ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... , Nov. 27, 2015 Research and ... the "Global Intrauterine Devices Market 2015-2019" report ... --> In this report, the author the ... devices market for 2015-2019. To calculate the market size, ... following type of products: Hormonal IUDs and copper IUDs. ...
(Date:11/27/2015)... , Nov. 26, 2015 ... addition of the "2016 Global Tumor ... Country Volume and Sales Segment Forecasts, Innovative ... report to their offering. --> ... of the "2016 Global Tumor Marker ...
(Date:11/26/2015)... , November 27, 2015 /PRNewswire/ ... --> Medical ... response system (PERS) market is ... 5 years with APAC being ... to see a high CAGR ...
Breaking Medicine Technology: