Navigation Links
Gene Test May Help Predict Colon Cancer's Return
Date:2/17/2009

A marker in lymph nodes points to more persistent tumors, scientists say

TUESDAY, Feb. 17 (HealthDay News) -- A genetic test may better help survivors of colorectal cancer determine their risk of recurrence, a new study finds.

A report in the Feb. 18 issue of the Journal of the American Medical Association finds that guanylyl cyclase C (GUCY2C) -- an intestinal tumor-suppressing receptor in the lymph nodes -- may better reveal the chance of metastatic colorectal cancer.

According to researchers from Thomas Jefferson University in Philadelphia, doctors often biopsy the lymph nodes when trying to determine the prognosis of colorectal cancer. But when no cancer cells are found (a condition called pN0 colorectal cancer), the chance of recurrence is still about one in four. If cancer cells are found in four or more lymph nodes, the recurrence odds jump to one in two.

In studying 257 people with pN0 colorectal cancer, the team found that GUCY2C analysis "appeared to be an independent prognostic marker of risk." While conventional molecular staging techniques found 13 percent of patients were free of tumor cells, GUCY2C results suggested malignancy in 87 percent of cases.

Improved molecular staging "could overcome limitations in the detection of occult lymph node metastases," wrote the researchers.

The authors called for more studies with larger patient pools to better access the accuracy and reliably of the genetic test.

More information

The U.S. National Cancer Institute has more about colorectal cancer.



-- Kevin McKeever



SOURCE: Thomas Jefferson University, news release, Feb. 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Anti-social behavior in girls predicts adolescent depression seven years later
2. Urine Test May One Day Predict Prostate Cancer
3. Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
4. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
5. MRI shows brain atrophy pattern that predicts Alzheimers
6. Gene Test Could Predict Thyroid Cancer Risk
7. Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer's Patients
8. Protein predicts liver cancer recurrence and after transplantation
9. Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
10. Blood Test May Predict Postpartum Depression
11. Mental Illness Doesnt Predict Violent Behavior
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Test May Help Predict Colon Cancer's Return 
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... Drs. Justin ... Awareness Week by teaching their patients about the key role this treatment plays in ... from an experienced endodontist. To better serve those who need a root canal in ...
(Date:3/27/2017)... Scottsdale, Arizona (PRWEB) , ... March 27, 2017 , ... ... in the top 10 for Rent the Runway Foundation and UBS’ Project Entrepreneur. Mayo ... New York on April 8. , Project Entrepreneur’s second annual venture competition ignites ...
(Date:3/27/2017)... ... March 27, 2017 , ... Osteitis pubis may ... of groin injury, it occurs when the muscles around the pelvis become inflamed. ... around the lower torso, as well as accompanying tenderness and weakness. Without proper ...
(Date:3/27/2017)... ... 27, 2017 , ... The Association of Healthcare and Value ... their first Northeast Regional AHVAP Meeting. For 2017, Dr. Hayes will provide the ... value analysis professionals have a ‘seat at the table’ with clinical committees when ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... announce the launch of a months-long rebranding effort. This includes the introduction of ... focus group discussions and market research, we learned that a simple, proactive approach ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... and PUNE, India , March 24, 2017 ... is estimated to reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% ... the highest revenue, and is projected to dominate the market during the study period. ... ... Market Research Logo ...
(Date:3/24/2017)... IRVINE, Calif. , March 24, 2017 ... ,the epigenetics company, and Hamilton Robotics, Inc., ... workstations, announced an ongoing collaboration that teams ... products and RNA and DNA extraction products ... has already created optimized methods for microbiomics ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of the ... offering. ... the worldwide markets for Dental Implants in US$ Million. The report provides ... Japan , Europe , Asia-Pacific ... Annual estimates and forecasts are provided for the period ...
Breaking Medicine Technology: