Navigation Links
Gene Test May Help Predict Colon Cancer's Return
Date:2/17/2009

A marker in lymph nodes points to more persistent tumors, scientists say

TUESDAY, Feb. 17 (HealthDay News) -- A genetic test may better help survivors of colorectal cancer determine their risk of recurrence, a new study finds.

A report in the Feb. 18 issue of the Journal of the American Medical Association finds that guanylyl cyclase C (GUCY2C) -- an intestinal tumor-suppressing receptor in the lymph nodes -- may better reveal the chance of metastatic colorectal cancer.

According to researchers from Thomas Jefferson University in Philadelphia, doctors often biopsy the lymph nodes when trying to determine the prognosis of colorectal cancer. But when no cancer cells are found (a condition called pN0 colorectal cancer), the chance of recurrence is still about one in four. If cancer cells are found in four or more lymph nodes, the recurrence odds jump to one in two.

In studying 257 people with pN0 colorectal cancer, the team found that GUCY2C analysis "appeared to be an independent prognostic marker of risk." While conventional molecular staging techniques found 13 percent of patients were free of tumor cells, GUCY2C results suggested malignancy in 87 percent of cases.

Improved molecular staging "could overcome limitations in the detection of occult lymph node metastases," wrote the researchers.

The authors called for more studies with larger patient pools to better access the accuracy and reliably of the genetic test.

More information

The U.S. National Cancer Institute has more about colorectal cancer.



-- Kevin McKeever



SOURCE: Thomas Jefferson University, news release, Feb. 17, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Anti-social behavior in girls predicts adolescent depression seven years later
2. Urine Test May One Day Predict Prostate Cancer
3. Levels of Circulating Tumor Cells Could Predict Prostate Cancer Outcome
4. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
5. MRI shows brain atrophy pattern that predicts Alzheimers
6. Gene Test Could Predict Thyroid Cancer Risk
7. Amyloid Beta Level in Serum Predicts Risk for Vascular Disease in First-Degree Relatives of Alzheimer's Patients
8. Protein predicts liver cancer recurrence and after transplantation
9. Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients
10. Blood Test May Predict Postpartum Depression
11. Mental Illness Doesnt Predict Violent Behavior
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Test May Help Predict Colon Cancer's Return 
(Date:7/9/2014)... type of lung cancer, researchers have uncovered mutations in ... tumors. The new knowledge may expand treatments for patients ... are available or are in clinical trials. , Reporting ... Cancer Genome Atlas (TCGA), including researchers at Washington University ... and other institutions, studied tumors from 230 patients with ...
(Date:7/9/2014)... Researchers have found that fecal transplantation is effective ... immunocompromised patients. This is the result of a study ... Center for Women,s Gastrointestinal Medicine at The Women,s Medicine ... online in advance of print in the American ... or C. diff , has increased to epidemic ...
(Date:7/9/2014)... N.Y. Although feelings are personal and subjective, ... code that objectively represents emotions across different senses, ... by Cornell University neuroscientist Adam Anderson. , "We ... the orbitofrontal cortex, an area of the brain ... code which captures an individual,s subjective feeling," says ...
(Date:7/9/2014)... 2014) Researchers from Montefiore Medical Center ... of Yeshiva University will present new findings at the ... July 17 in Copenhagen, Denmark. Data from the ... transition from cognitive normality to mild cognitive impairment and ... Aging Study , established in 1980 to examine healthy ...
(Date:7/9/2014)... have a reputation for being highly toxic, but when used ... being found to offer potential health benefits in a range ... A new compound (AP39), designed and made at the University ... targeting delivery of very small amounts of the substance to ... in Exeter have already found that the compound protects mitochondria ...
Breaking Medicine News(10 mins):Health News:Lung cancer study hints at new treatments 2Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:Study cracks how the brain processes emotions 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Rotten egg gas holds key to healthcare therapies 2
... 1 The Unilens Vision Inc. (OTC Bulletin Board: UVICF) (TSX ... dividend of U.S. $0.09 per common share, payable February 26, ... on February 12, 2010 .   , "We are pleased to ... a annualized dividend rate of U.S. $0.36 per share provides ...
... College Dublin researchers could benefit young adults (aged 18-25 ... Nolan of Trinity College Dublin and St James,s Hospital, Dublin, ... Diabetes Care . The study findings demonstrate new ... which is the body,s decreased ability to respond to the ...
... innate interest in the new and different may help ... published by the American Psychological Association. In controlled experiments, ... got cocaine. Novelty could help break the ... many addicts with novelty-craving, risk-taking personalities, the authors said. ...
... health both before and after a major event like a ... of quitting have a positive effect as well? ... Aviv University, the largest and most comprehensive of its kind. ... attack has about the same positive effect as other major ...
... ... & Poor’s Rating Services have upgraded Scripps Health from an A+ to ... million in California Health Facilities Finance Authority revenue bonds. Proceeds from the ... Scripps Health’s various patient care facilities and will reimburse Scripps Health for ...
... Registration ... locations across the U.S. and Canada. , ... Madison, WI (PRWEB) February 1, 2010 -- Trek Bicycle, North America’s largest domestic ... mountain bike skills program today. Designed to help riders of all experience levels, particularly women, ...
Cached Medicine News:Health News:Unilens Vision Inc. Declares Regular Quarterly Cash Dividend of U.S. $0.09 Per Share 2Health News:New research on type 2 diabetes could benefit young adults with the condition 2Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 2Health News:Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts 3Health News:Smoker alert: Information you can live with 2Health News:Fitch, Standard & Poor's Upgrade Scripps Health to AA-; Scripps to Issue $220 Million in Hospital Revenue Bonds 2Health News:Trek Bicycle Announces Title Sponsorship of 2010 Dirt Series 2Health News:Trek Bicycle Announces Title Sponsorship of 2010 Dirt Series 3
(Date:1/15/2014)... -- ChinaMarketResearchReports.com adds "China Orthopedic Instrument Industry Report, 2013-2015" ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) Benefiting from aging ... China,s orthopedic instrument industry has seen rapid ... from 3.28 billion yuan in 2006 to 9.85 billion ...
(Date:1/15/2014)... As health officials across the Midwest warn against the widespread ... Michigan will offer free diagnostic testing for ... to administer tests and, in some cases, fill the matching ... the study. The Grand Rapids, Mich. ...
(Date:1/15/2014)... , Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... commitments from institutional investors to purchase an aggregate of ... an at-the-market registered direct offering, led by a dedicated ... definitive purchase agreements with these investors pursuant to which ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: