Navigation Links
Gene Test Could Predict Colon Cancer's Return
Date:11/25/2008

Key DNA might also help guide treatment choices, researchers say

TUESDAY, Nov. 25 (HealthDay News) -- U.S. researchers say they've developed a genetic model for predicting the risk of recurrence in patients with early stage colon cancer.

According to a team at the Duke Institute for Genome Science & Policy, the model also predicts colon cancer's sensitivity to chemotherapy and targeted therapy regimens.

The researchers looked for gene expression patterns in 52 samples of early stage colon cancer tumors and correlated those patterns with patient outcomes. They then tested the predictive power of those correlations in two independent data sets from 55 and 73 tumors.

"In our small dataset, we were able to predict which tumors were at risk for recurring with 90 percent accuracy," lead investigator and gastroenterology fellow Dr. Katherine Garman, said in a Duke news release.

The researchers then used the data about gene expression and patient prognosis to study response to several types of cancer therapy.

"Importantly, we found that the traditional chemotherapy given to patients with colon cancer varies considerably in its ability to treat tumors with a high likelihood of cancer recurrence," Garman said. "Using the gene-expression data to guide use, we then identified several other drugs and tested those drugs in our samples. The drugs chosen were novel targeted therapies and anti-inflammatory agents that go after certain cancer cell pathways and had been previously shown to alter colon cancer biology."

Two of the drugs tested by the researchers appeared to "cause significant changes in tumor biology in a laboratory dish, effectively making a high-recurrence-risk tumor into a low-recurrence-risk tumor by altering the genetic makeup," said Garman, who added that these therapies require further testing in clinical trials.

The study was published online this week in the journal
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Study provides hope that some transplant patients could live free of antirejection drugs
2. Study provides hope that some transplant patients could live free of anti-rejection drugs
3. HIV denialists spread misinformation online -- consequences could be deadly; and more
4. Virus Could Help Drive Obesity
5. Discovery of sugar sensor in intestine could benefit diabetes
6. Cranberry Could Juice Up Ovarian Cancer Treatment
7. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
8. High-risk behaviors could lead to HIV epidemic in Afghanistan
9. Chinas 1-child policy could backfire on its elderly
10. 1.5 million children could be saved
11. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Test Could Predict Colon Cancer's Return
(Date:7/2/2015)... ... 2015 , ... eHuman Digital Anatomy, the industry leader in ... product, 3D Tooth Atlas, version 7.6. This release delivers new and improved features, ... latest release of the 3D Tooth Atlas offers a much faster graphic loading ...
(Date:7/2/2015)... , ... July 02, 2015 , ... ... to healthcare providers, has been retained to lead a national chief operating ... top executive search firms in the healthcare industry, B. E. Smith has recently ...
(Date:7/2/2015)... (PRWEB) , ... July 02, 2015 , ... ... overall status of the Gelatin Capsule manufacturers. The report is a valuable source ... The report depicts the global and Chinese market for the Gelatin Capsule industry ...
(Date:7/2/2015)... ... July 02, 2015 , ... Catalent Pharma Solutions, the ... and consumer health products, today announced that it has made two key appointments ... new General Manager at Catalent’s Schorndorf facility, which provides large scale, complex oral ...
(Date:7/2/2015)... Ohio (PRWEB) , ... July 02, 2015 , ... Today, ... Director of the Surgical Center at East Liverpool City Hospital (ELCH). Pam is currently ... the duties of the director of surgery. Pam holds a master’s degree in health ...
Breaking Medicine News(10 mins):Health News:eHuman Digital Anatomy Releases 3D Tooth Atlas version 7.6 2Health News:Nicklaus Children’s Hospital Retains B. E. Smith to Recruit New Chief Operating Officer 2Health News:Nicklaus Children’s Hospital Retains B. E. Smith to Recruit New Chief Operating Officer 3Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 2Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 3Health News:Gelatin Capsule Market Outlook & Forecast Report 2015-2020 4Health News:Catalent Makes Two Key European Appointments in Oral Dose Manufacturing 2Health News:East Liverpool City Hospital Announces New Surgical Center Leadership 2Health News:East Liverpool City Hospital Announces New Surgical Center Leadership 3
... sales growth and EPS of $.85, Q3 pro forma adjusted results include 13 percent sales ... ... $3.50 - $3.55, or ... INDIANAPOLIS, Oct. 18 Eli Lilly and Company,(NYSE: LLY ) today announced strong financial ...
... for the,first-ever HIMSS Virtual Conference & Expo on ... studies from the,National Center for Education Statistics showing ... education in the United States are on the,rise, ... host its second exclusively online conference on Nov. ...
... for Hangovers and Holiday Party Faux Pas, ... a string of,parties and celebrations, the trickiest being ... between fun and foolishness. This holiday,season, Rescue Beverage ... hangover remedy to relieve the negative effects,of alcohol, ...
... Our ... Telemedicine Product Line, SUN VALLEY, Calif., Oct. 18 ... new,Bluetooth(R) enabled telemedicine products to their line of disease,management solutions for ... "The addition of A & D,s Bluetooth(R) enabled Blood Pressure ...
... shopping is usually viewed as,a leisure activity by ... the,habit is a process addiction. For these "shopaholics," ... and trying on new work clothes. Rather, their,"retail ... into financial and,emotional disaster. "Addiction is a ...
... release is available in French . , ... that the human papillomavirus (HPV) screening test is far ... cervical cancer. The first round of the Canadian Cervical ... Director of the Division of Cancer Epidemiology at McGill,s ...
Cached Medicine News:Health News:Lilly Delivers Strong Third-Quarter Results 2Health News:Lilly Delivers Strong Third-Quarter Results 3Health News:Lilly Delivers Strong Third-Quarter Results 4Health News:Lilly Delivers Strong Third-Quarter Results 5Health News:Lilly Delivers Strong Third-Quarter Results 6Health News:Lilly Delivers Strong Third-Quarter Results 7Health News:Lilly Delivers Strong Third-Quarter Results 8Health News:Lilly Delivers Strong Third-Quarter Results 9Health News:Lilly Delivers Strong Third-Quarter Results 10Health News:Lilly Delivers Strong Third-Quarter Results 11Health News:Lilly Delivers Strong Third-Quarter Results 12Health News:Lilly Delivers Strong Third-Quarter Results 13Health News:Lilly Delivers Strong Third-Quarter Results 14Health News:Lilly Delivers Strong Third-Quarter Results 15Health News:Lilly Delivers Strong Third-Quarter Results 16Health News:Lilly Delivers Strong Third-Quarter Results 17Health News:Lilly Delivers Strong Third-Quarter Results 18Health News:Lilly Delivers Strong Third-Quarter Results 19Health News:HIMSS' Second Virtual Conference & Expo Less Than a Month Away 2Health News:HIMSS' Second Virtual Conference & Expo Less Than a Month Away 3Health News:HIMSS' Second Virtual Conference & Expo Less Than a Month Away 4Health News:Make a Toast, Not a Scene: Five Tips for the Holiday Office Party 2Health News:XTend Medical (XDMC) Adds New Bluetooth(R) Telemedicine Products From A&D Medical 2Health News:Shopping Sprees Can Cost More Than You Think: How to Identify a Shopping Addiction 2Health News:Shopping Sprees Can Cost More Than You Think: How to Identify a Shopping Addiction 3Health News:Study: HPV test beats Pap in detecting cervical cancer 2Health News:Study: HPV test beats Pap in detecting cervical cancer 3
(Date:7/2/2015)... 2, 2015  Konica Minolta, Inc. (Konica Minolta) ( ... has acquired Sawae Technologica Ltda., an X-ray system equipment ... , through its Brazilian healthcare sales company, Konica Minolta ... Local Brazil market investment and ... exceeding 200 million, significant healthcare technical advancements and efficiencies ...
(Date:7/2/2015)... 2, 2015  The Commission for Certification in ... an organization that represents pharmacists in acute and ... continuing education for recertification of Certified Geriatric Pharmacists.  ... programs for this purpose.  ASHP will join the ... for the CCGP Professional Development Program. ...
(Date:7/2/2015)... 2, 2015   BioLife Solutions , Inc. (NASDAQ: ... clinical grade cell and tissue hypothermic storage and ... hosted biologistics cold chain management app for smart ... Seattle Business Magazine has included BioLife in its annual ... Washington state for 2015. ...
Breaking Medicine Technology:Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 2Konica Minolta Acquires Sawae, Enhancing Digital X-ray Diagnostic Imaging Systems in Brazil 3Commission for Certification in Geriatric Pharmacy Adds ASHP as Professional Development Program Provider 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 2BioLife Solutions Named One of the 100 Best Companies to Work For in Washington State 3
... WIRE)--Mar 22, 2007 - Aeolus,Pharmaceuticals, Inc. (OTCBB:AOLS) announced ... from the Company's phase 1,multiple-dose study of AEOL ... is currently under consideration, with the,most likely targets ... healthy,cells in radiation therapy in lung cancer and/or ...
... BLOOMFIELD, N.J., March 22, 2007 /PRNewswire-FirstCall/ --,Alfacell ... show mild,hyperthermia enhances the therapeutic effects of ... In a paper entitled, "Mild hyperthermia predisposes ... ONCONASE," published in,the International Journal of Oncology ...
Cached Medicine Technology:Aeolus Pharmaceuticals Announces Successful Completion of Multiple,Dose Safety Study of AEOL 10150 2Aeolus Pharmaceuticals Announces Successful Completion of Multiple,Dose Safety Study of AEOL 10150 3Aeolus Pharmaceuticals Announces Successful Completion of Multiple,Dose Safety Study of AEOL 10150 4Studies Show Mild Hyperthermia Enhances Antitumor Effects of,Alfacell's Onconase 2Studies Show Mild Hyperthermia Enhances Antitumor Effects of,Alfacell's Onconase 3
Equinox is a truly unique approach to cosmetic enhancement contact lenses and is worn as a conventional wear lens....
... to capture and process ultrasound images, Zone ... revolutionary advancement. The z.one platform, powered by ... Ultrasound system, instantly converting from a full-featured ... system with all the performance of substantially ...
... KMI Diagnostics is a CLIA-certified diagnostic laboratory ... and a limited number of other analytes ... across the United States. We also ... laboratory services and pre-clinical trials services. ...
For the qualitative detection of Infectious mononucleosis IgM heterophile antibodies in human whole blood, serum and plasma specimens....
Medicine Products: