Navigation Links
Gene Test Could Predict Colon Cancer's Return
Date:11/25/2008

Key DNA might also help guide treatment choices, researchers say

TUESDAY, Nov. 25 (HealthDay News) -- U.S. researchers say they've developed a genetic model for predicting the risk of recurrence in patients with early stage colon cancer.

According to a team at the Duke Institute for Genome Science & Policy, the model also predicts colon cancer's sensitivity to chemotherapy and targeted therapy regimens.

The researchers looked for gene expression patterns in 52 samples of early stage colon cancer tumors and correlated those patterns with patient outcomes. They then tested the predictive power of those correlations in two independent data sets from 55 and 73 tumors.

"In our small dataset, we were able to predict which tumors were at risk for recurring with 90 percent accuracy," lead investigator and gastroenterology fellow Dr. Katherine Garman, said in a Duke news release.

The researchers then used the data about gene expression and patient prognosis to study response to several types of cancer therapy.

"Importantly, we found that the traditional chemotherapy given to patients with colon cancer varies considerably in its ability to treat tumors with a high likelihood of cancer recurrence," Garman said. "Using the gene-expression data to guide use, we then identified several other drugs and tested those drugs in our samples. The drugs chosen were novel targeted therapies and anti-inflammatory agents that go after certain cancer cell pathways and had been previously shown to alter colon cancer biology."

Two of the drugs tested by the researchers appeared to "cause significant changes in tumor biology in a laboratory dish, effectively making a high-recurrence-risk tumor into a low-recurrence-risk tumor by altering the genetic makeup," said Garman, who added that these therapies require further testing in clinical trials.

The study was published online this week in the journal Proceedings of the National Academy of Sciences.

"These findings have important implications for individualizing therapy," Garman said. "By examining gene expression in early-stage colon cancer tumors, we have found certain patterns that seem to put some patients at higher risk for recurrence. By identifying these patients up front, we may be able to treat them in a targeted and proactive manner to prevent this recurrence and help them live longer and healthier lives."

More information

The American Cancer Society has more about colorectal cancer.



-- Robert Preidt



SOURCE: Duke Medicine, news release, Nov. 24, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study provides hope that some transplant patients could live free of antirejection drugs
2. Study provides hope that some transplant patients could live free of anti-rejection drugs
3. HIV denialists spread misinformation online -- consequences could be deadly; and more
4. Virus Could Help Drive Obesity
5. Discovery of sugar sensor in intestine could benefit diabetes
6. Cranberry Could Juice Up Ovarian Cancer Treatment
7. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
8. High-risk behaviors could lead to HIV epidemic in Afghanistan
9. Chinas 1-child policy could backfire on its elderly
10. 1.5 million children could be saved
11. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Test Could Predict Colon Cancer's Return
(Date:8/19/2017)... ... August 19, 2017 , ... Praeclarus ... breastfeeding mothers. These illustrations show the diversity of the breastfeeding mothers, using ... wide range of sizes. These illustrations are also available on tote bags, notepads, ...
(Date:8/18/2017)... ... August 19, 2017 , ... ... Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, ... Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT said, “Thailand ...
(Date:8/18/2017)... York, NY (PRWEB) , ... August 18, 2017 ... ... launch of this summer’s edition of “Vision & Hearing,” advocating for active, healthy ... campaign focuses on resources available for individuals with hearing impairments and shares the ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... and asset protection assistance to communities in North-Central West Virginia, is embarking on ... to at-risk boys in the area. , The Chestnut Mountain Ranch (CMR) is ...
(Date:8/18/2017)... ... ... The Golseth Agency, a Texas based insurance management and financial planning assistance ... campaign organized to provide support to Christina Upchurch and her two children after the ... children returned from out of town to find her husband passed away and their ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... Colo. , Aug. 10, 2017  Physical Rehabilitation Network ... located in Lakewood, Colorado . The reputable ... Jeff Lipkin , PT, DPT with his staff of four ... University of Pittsburgh and brings over 10 years of experience ... Belmar PT marks the 10th PRN clinic in ...
(Date:8/7/2017)... Md. , Aug. 7, 2017 ... healthcare member acquisition, retention, and engagement, announced the ... of Strategy and Product Development, effective as of ... consulting and technology implementation strategy for our clients. ... of experience in consulting and business analytics within ...
(Date:8/7/2017)... Inc. (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced ... comparisons, unless otherwise noted, are to the quarter ended June ... Quarter 2017 Highlights include: Revenue of ... Total prescriptions dispensed of 220,000, compared to ... Gross profit per prescription dispensed of ...
Breaking Medicine Technology: