Navigation Links
Gene-Targeted Cancer Fix Could Be a Breakthrough
Date:3/21/2010

For first time in humans, scientists used RNA to stop production of protein driving malignancy

SUNDAY, March 21 (HealthDay News) -- For the first time in humans, scientists have successfully used a gene-manipulation therapy to enter tumor cells and block the production of toxic proteins that are causing cancer, researchers report.

"They're basically putting an instruction booklet into the cell saying, 'We don't want this protein expressed for now,'" explained Gregory Adams, co-leader of the developmental therapeutics program at Fox Chase Cancer Center in Philadelphia. "It's pretty amazing. It's potentially huge."

"This is something we've been waiting to see," he continued.

"This directly interferes with the genetic mechanisms that promote cancer to stop the production of a particular protein," added Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. "This is one step away from getting into the actual DNA."

As reported online March 21 in Nature, this is the first time the process, known as RNA interference (RNAi), has been shown to work in humans.

The process of RNA interference involves putting two strands of RNA together to form so-called "small interfering RNAs" (siRNAs) and inserting them into cells. Once there, these interlopers cut the messenger RNA (mRNA) that is ordinarily used to make specific proteins. This discovery won the Nobel Prize in 2006.

But the work that nabbed the prize was done in worms -- a far cry from humans.

And there were other challenges, not the least of which was how to get the siRNAs into the appropriate cell and then make sure they did what they were supposed to do.

This team, from the California Institute of Technology (CalTech), devised a super-small nanoparticle system that, when injected into the body, would make its way to the tumor, deposit the siRNAs into the tumor cell and leave them to
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Newer Genetic Info Adds Little to Predicting Breast Cancer
2. Disabling Skp2 gene helps shut down cancer growth
3. Researchers find new chemotherapy combination shows promise in endometrial cancer
4. Latest Cancer Clinic Closure in Selma, Alabama
5. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
6. Nurses research settles a common cancer concern: Skin care
7. Cancer Articles Tend to Focus on Positive Outcomes
8. SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
9. BioSphere Medical's HepaSphere Microspheres Safely Deliver Doxorubicin in Liver Cancer Chemoembolization Therapy -- Study Presented at SIR
10. Pain Relief Often Delayed for Cancer Patients
11. Prostate Cancer Radiation Side Effects May Subside With Time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... (PRWEB) September 30, 2014 NAPW ... Clinical Manager Specialist, as a 2014 Professional Woman of ... distinction for leadership in clinical care. As the largest ... virtually every industry and profession, the National Association of ... over 600,000 members and nearly 300 Local Chapters. , ...
(Date:9/29/2014)... Every autumn, as high school and college gets ... takes off! Athletes typically train throughout the summer in ... the leading compression apparel company, makes the best ... for cross country running. , The compression leg ... muscle soreness (DOMS) throughout training in addition to speeding ...
(Date:9/29/2014)... 2014 China’s regulatory framework for ... country’s new leaders have recognized that the regulations ... are far from perfect along with rapid population ... years. Chinese state council issued the latest “Regulations ... on February 12, 2014, and it has come ...
(Date:9/29/2014)... (PRWEB) September 29, 2014 Leading Conejo ... (PMIR) and Thousand Oaks Surgery Center (TOSC) –– are ... a state-of-the-art healthcare facility in Thousand Oaks, Calif. The ... practices that offer Conejo Valley residents greater access to ... and chronic pain, while TOSC physicians are setting the ...
(Date:9/29/2014)... The Pulmonary Hypertension Association ... Centers (PHCC) in a program that seeks to ... of patients with pulmonary hypertension (PH), specifically pulmonary arterial ... the lungs that affects the functioning of the heart ... mean survivability is only 2.8 years. , Despite medical ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Announces Sarah Shiermeister, Clinical Manager Specialist at Gentiva Health Services, a 2014 Professional Woman of the Year 2Health News:Muscle Support and Style With New Compression Leg Sleeves For Cross Country Runners 2Health News:Chinese Regulations on In-Vitro Diagnostic Reagents Market: Application & Approval 2014 Edition New Study Now Available at MarketReportsOnline.com 2Health News:Chinese Regulations on In-Vitro Diagnostic Reagents Market: Application & Approval 2014 Edition New Study Now Available at MarketReportsOnline.com 3Health News:Chinese Regulations on In-Vitro Diagnostic Reagents Market: Application & Approval 2014 Edition New Study Now Available at MarketReportsOnline.com 4Health News:New Thousand Oaks Medical Facility Hosts Grand Opening Event: Two Practices, One Celebration 2Health News:New Thousand Oaks Medical Facility Hosts Grand Opening Event: Two Practices, One Celebration 3Health News:Pulmonary Hypertension Association Accredits First Six PH Care CentersApplication Process Now Open 2Health News:Pulmonary Hypertension Association Accredits First Six PH Care CentersApplication Process Now Open 3Health News:Pulmonary Hypertension Association Accredits First Six PH Care CentersApplication Process Now Open 4
... Society for Technology in Anesthesia Annual Meeting Quantifies ... Improved ICU UtilizationIRVINE, Calif., Jan. 20 Masimo ... Pulse CO-Oximetry and Measure-Through Motion and Low Perfusion ... clinicians at Dartmouth-Hitchcock Medical Center (DHMC) presented new ...
... its 2008 distributions as follows:, Security Description: Common Stock, ... Ticker Symbol: BMR, ... Total ... Ordinary, Date Date ...
... clients in these tough economic times. , ... Wayne, NJ (PRWEB) January ... being hit hard. To succeed, CMS, a leader in the staffing ... moves such as utilizing the temporary workforce. , ,By ...
... 19 Anyone who has gone through,finding a long-term ... is,to search for and find a care facility such ... know how senior living can be expensive and stressful,trying ... and meets the,financial demands of senior citizens without knowing ...
... operation differ about 20% of the time, researchers say ... severe osteoarthritis tend to be happier with their care ... providers on the issue of total knee replacement, a ... patients don,t agree with providers when it comes to ...
... recommended care did better, regardless of race, study found ... between white and black patients with early-stage lung cancer ... a U.S. study that included nearly 18,000 patients. ... (pulmonary resection) provides the best chance of a cure ...
Cached Medicine News:Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 2Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 3Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 4Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 5Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 6Health News:Clinicians at Dartmouth-Hitchcock Medical Center Present New Data Showing Masimo Rainbow SET(R) Oximetry and Patient SafetyNet(TM) Improves Patient Outcomes and Reduces the Cost of Care 7Health News:BioMed Realty Trust Announces Tax Treatment of 2008 Distributions 2Health News:BioMed Realty Trust Announces Tax Treatment of 2008 Distributions 3Health News:CMS Staffing Announces a its New and Revolutionary Consultative Approach With Clients 2Health News:Raising the Quality of Long-Term Care for Seniors 2Health News:Raising the Quality of Long-Term Care for Seniors 3Health News:Knee Replacement Works Best When Patients, Providers Agree 2Health News:Optimal Treatment Boosts Blacks' Lung Cancer Survival 2
(Date:9/29/2014)... 2014 Kush Bottles, North America,s ... and consulting services for the medical and recreational marijuana ... has assumed the role of Chief Executive Officer. ... and worked as COO until February of 2014, returned ... other ventures. His return marks a clear dedication to ...
(Date:9/29/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE Amex: ... specializes in patented biopharmaceutical, modernized traditional Chinese medicine ... today announced that its Qionglai Facility (QLF) has ... China Food & Drug Administration,s (CFDA) for its ... early September 2014, the Company has submitted the ...
(Date:9/29/2014)... and CAMBRIDGE, Mass. ... Solutions and KEW Group, Inc. (KEW), a privately ... for the two companies to make KEW,s state-of-the-art ... customers. KEW is a privately held ... cancer care by empowering all oncologists to access ...
Breaking Medicine Technology:Kush Bottles Co-Founder Steps into Role of CEO 2TPI's QLF Completes GMP site inspection by CFDA 2TPI's QLF Completes GMP site inspection by CFDA 3Cardinal Health Specialty Solutions, KEW Group Bring Power of Personalized Medicine to Community Oncologists 2Cardinal Health Specialty Solutions, KEW Group Bring Power of Personalized Medicine to Community Oncologists 3Cardinal Health Specialty Solutions, KEW Group Bring Power of Personalized Medicine to Community Oncologists 4
... Oslo Cancer Cluster represents a strong R&D environment dedicated ... lies within developing novel technologies and significantly better cancer ... Oslo Cancer Cluster is a research and ... accelerating the development of new cancer diagnostics and medicines. ...
... 31, 2011 Menicon Holdings BV and Eye Shelter ... France-based independent ophthalmic group, announced on October 31 that ... market the SOLO-care (R) contact lens solutions range in ... The agreement will enable Menicon to significantly ...
Cached Medicine Technology:Expanding Norwegian Cluster of Excellence Dedicated to Oncology 2Expanding Norwegian Cluster of Excellence Dedicated to Oncology 3Menicon to Market Eye Shelter's SOLO-care (R) Contact Lens Solution Range in Europe and Canada 2
The 6.5mm cannulated cancellous ACE SCFE Screw is specifically designed for the treatment of slipped capital femoral epiphysis. The ACE SCFE Screw simplifies insertion and facilitates removal....
Smith & Nephew offers a wide variety of cannulated screw products. Most screw sizes are available in both partially threaded and fully threaded versions. , ,All systems optimize implant strength with...
... Humeral Nail enables fixation of humeral shaft ... may be associated with antegrade nailing. , ... distal interlocking using a nail-mounted targeting device. ... with the patient in the prone position. ...
... leading medical technology company and a ... more than a decade, introduces a ... ACT Plus System is a microprocessor-controlled ... coagulation endpoints in whole blood, citrated ...
Medicine Products: