Navigation Links
Gene Study Yields New Clues to Crohn's Disease, Colitis
Date:10/31/2012

WEDNESDAY, Oct. 31 (HealthDay News) -- Scientists say research into the genetics of inflammatory bowel disease -- which includes Crohn's disease and ulcerative colitis -- is revealing new insights into the origin of this set of illnesses.

The researchers said they have linked genetic variations in 163 regions of the human genome with a heightened risk of developing inflammatory bowel disease (IBD). Of those regions, 71 are newly discovered.

IBD comprises a group of chronic, autoimmune digestive disorders that affect 2.5 million people worldwide. Symptoms include abdominal pain and diarrhea and patients typically require lifelong treatment with drug therapy. Many also require surgery to repair tissue damage caused by the disease.

In this study, researchers analyzed data from about 34,000 people who took part in 15 previous studies of either Crohn's disease or ulcerative colitis. They also examined data from genome-wide scans of more than 41,000 DNA samples from Crohn's disease and ulcerative colitis patients collected at 11 centers around the world.

In addition to confirming that 92 regions of the human genome identified in previous studies are associated with a significant risk for the two illnesses, the new study linked 71 new regions to IBD.

The regions pinpointed in this study overlap those linked with other autoimmune diseases and suggest that IBD results from overactive immune defense systems that evolved to combat serious bacterial infections, the researchers said.

The findings appear in the Nov. 1 issue of the journal Nature.

"Until this point we have been studying the two main forms of IBD -- Crohn's disease and ulcerative colitis -- separately," co-lead author Judy Cho, professor of gastroenterology and genetics at Yale School of Medicine, said in a Yale news release. "We created this study based on what seems to be a vast amount of genetic overlap between the two disorders."

The new study reveals "a genetic balancing act between [the immune system] defending against bacterial infection and attacking the body's own cells," co-lead author Jeffrey Barrett of the Wellcome Trust Sanger Institute in Cambridge, England, said in the news release. "Many of the regions we found are involved in sending out signals and responses to defend against bad bacteria. If these responses are over-activated, we found it can contribute to the inflammation that leads to IBD."

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about Crohn's disease.

-- Robert Preidt

SOURCE: Yale University, news release, Oct. 31, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Health inequalities could be reduced by more effective health care, says new study
2. Automated calls help patients in under-developed countries manage blood pressure, U-M study finds
3. Health inequalities could be reduced by more effective healthcare, says new study
4. Study suggests too much risk associated with SSRI usage and pregnancy
5. Flirting Works as Negotiation Tactic for Women: Study
6. Study suggests new way to prevent recurrent ear infections
7. Using Canadas Health System as Model Might Cut U.S. Costs: Study
8. The Biggest Loser May Sour Viewers on Exercise, Study Finds
9. Fast-Food Breakfast Sandwiches May Slow Down Blood Flow: Study
10. Breast Cancer Survival Varies by Race, Ethnicity, Study Shows
11. Autism Tough to Spot Before 6 Months of Age, Study Suggests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Study Yields New Clues to Crohn's Disease, Colitis
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
(Date:6/23/2016)... June 23, 2016  Guerbet announced today that it ... Supplier Horizon Award . One of 12 ... recognized for its support of Premier members through exceptional ... excellence, and commitment to lower costs. ... recognition of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... YORK , June 23, 2016 ... waters, but it continues to present great opportunities to ... companies for today: Intrexon Corp. (NYSE: XON ... Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), and ... more about these stocks and receive your complimentary trade ...
Breaking Medicine Technology: