Navigation Links
Gene Studies of Male-Female Differences Often Flawed
Date:8/21/2007

Too often, statistics are weak or unsubstantiated, review finds

TUESDAY, Aug. 21 (HealthDay News) -- Claims of male-female differences in how genes affect disease often lack proper documentation or validation, experts report in the Aug. 22/29 issue of the Journal of the American Medical Association.

A team of researchers in Greece analyzed 77 studies that contained 432 gender-difference claims.

They found that 286 (66.2 percent) of these claims were decided in advance of the study, and 68 (15.7 percent) were drawn from post-study analyses. The analysis plan was unclear in 78 (18.1 percent) of the studies.

The review also found that appropriate documentation of gene-sex interaction was recorded in just 55 claims (12.7 percent), while there was insufficient documentation for 303 claims and invalid documentation for 74 claims.

Dr. Nikolaos A. Patsopoulos of the University of Ioannina School of Medicine and colleagues concluded that "the majority of these claims were insufficiently documented or spurious, and reporting of statistical interaction tests was rare."

"We hope that our empirical evaluation will help sensitize clinicians, geneticists, epidemiologists, and statisticians who are pursuing subgroup analyses by sex or other subgroups on genetic associations," the researchers said.

In many cases, the proof of any real gender-based gene differences was weak. For example, data for re-analysis of gender-difference claims were available for 188 comparisons, the research team said. Of those, 83 (44.1 percent) were nominally statistically significant, and more than half of those (44) failed to reach nominal statistical significance of a certain level, the review authors said.

Of 60 claims with seemingly "the best internal validity," only one was consistently replicated in at least two other studies.

Studies of gene-sex interactions shouldn't be abandoned but should be conducted using more rigorous standards and documentation, the Greek team said. In addition, the results of such studies should be replicated by several other studies before the findings are accepted as valid, they wrote.

More information

The U.S. Food and Drug Administration has more about gender and disease.



-- Robert Preidt



SOURCE: JAMA news release, Aug. 21, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Studies On Hearing Loss Discovers New Causes
2. Broccoli Found to Block Cancer Progression In Both Animal and Human Studies
3. Studies Report Mammograms Unsafe
4. Six Indians Win Australian Studies Fellowships
5. Cure For Autism Could Be Established Through Hamster Studies
6. Despite More Studies Researchers Are Still Confound With ADHD
7. Studies Show Brain becomes Less Specialized With Age
8. ISB To Establish Research Chair On Real Estate And Urban Studies
9. Studies Show Combination Drugs As A Poor Substitute For Anti-Coagulants In Stroke
10. Further Studies Needed To Completely Understand About Ventricular Fibrillation
11. Circumcision Studies to Continue Says Health Panel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... , ... October 12, 2017 , ... ... a leader in post-acute health care, have expanded their existing home health joint ... Health. , AccentCare has been operating a joint venture home health company with ...
(Date:10/12/2017)... ANGELES (PRWEB) , ... October 12, 2017 , ... ... Parsa Mohebi Hair Restoration, has recently contributed a medical article to the newly ... on cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Leading pediatric ... peers in Washington, D.C., for the 49th Congress of the International Society of ... Vice President of the Center for Cancer and Blood Disorders at Children’s ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United ... year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and ... havens have extremely low property-tax rates, which contributes to the relatively lower cost ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
(Date:9/25/2017)... Sept. 25, 2017  EpiVax, Inc., a leader ... and immune-engineering today announced the launch of EpiVax ... of personalized therapeutic cancer vaccines. EpiVax has provided ... access to enabling technologies to the new precision ... lead EpiVax Oncology as Chief Executive Officer. Gad ...
(Date:9/19/2017)... Inc., a venture-backed medical device company developing a non-invasive, robotically assisted, platform therapy that uses ... today:   ... Jim ... Tom Tefft ... Veteran medical device executive Josh Stopek , PhD, who has led R&D and business ...
Breaking Medicine Technology: