Navigation Links
Gene Studies Reveal Cancer's Secrets
Date:4/22/2009

Key alterations hold clues to blood, bladder and ovarian malignancies, researchers say,,

TUESDAY, April 21 (HealthDay News) -- A close look at a tumor's or patient's genetics can provide important, potentially lifesaving clues to preventing and treating cancer.

So say scientists who outlined their research Tuesday in five presentations at the American Association for Cancer Research's annual meeting, in Denver.

"This is an interesting set of presentations," John S. Witte, a professor in the Institute for Human Genetics at the University of California, San Francisco, said during a midday press conference. "All the studies have an impact on the potential to predict risk or recurrence or response to treatment," he said.

In the first study, researchers led by Dr. Charles Mullighan, an assistant member at St. Jude Children's Research Hospital, Memphis, found that children with acute lymphoblastic leukemia (ALL) who have mutations in the JAK tyrosine kinase gene generally have poor outcomes, including a higher risk of recurrence of their cancer. The finding suggests the gene could be a potential diagnostic tool and a new therapeutic target.

Despite improvements in treatment, some children with ALL will relapse, Mullighan told reporters.

For the study, the Memphis team analyzed the genes of 221 children with the disease.

Although JAK mutations were not previously known to occur in children with ALL, they were discovered in 10 percent of these patients. The mutations were associated with a deletion of the genes IKZF1 and CDKN2A/B and poor outcome. And, over four years, 71 percent of the children with JAK and IKZF1 alterations had a relapse of their disease, compared with only 23 percent for patients without these genetic alterations, the researchers found.

But there was good news, too. "When we treated the cancer cells with a JAK inhibitor, the cells died," Mullighan said. "This su
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3 4 5

Related medicine news :

1. NKTR-105 Demonstrates Superior Antitumor Activity and Improved Pharmacokinetics Over Docetaxel in Preclinical Studies Presented at AACR
2. Mersanas Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
3. PRA SPEAKING EVENT: Phase I Studies with Hepatitis C Compounds in Healthy Volunteers and Patients: Views from Inside
4. Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-101, Potent Small Molecule for Treatment of Alzheimers Disease.
5. New head-to-head clinical studies reveal Reach Ultraclean toothbrush and floss deliver superior plaque removal compared to leading competitive products
6. New studies examine elimination of hepatitis B and C
7. By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies
8. Five Research Studies at International SRCD Meeting in Denver Use Technology from Boulder Foundation
9. Academy of Lymphatic Studies Announces Accelerated Hybrid Online Program
10. 2 Studies Conflict Over Value of Prostate Cancer Screening
11. Massachusetts Studies Reveal Importance of Incentives in Healthcare Technology Adoption
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Studies Reveal Cancer's Secrets
(Date:8/19/2014)... Skmen.com, an outstanding company in the garment industry, has unveiled ... addition to this, the company has also launched a big ... available at low rates, up to 30 percent off. ... beautiful bohemian outfits are available in many colours, including green, ... top quality clothes, reasonable prices and sincere service, the company ...
(Date:8/19/2014)... 2014 Recently, CanadaGooseJackor.nu, a popular supplier of ... Canada Goose Solaris Parkas . All clients that place ... discounted price (up to 35% off) before the end of ... in an online supplier’s business. CanadaGooseJackor.nu is a great platform ... all over the world can enjoy its dedicated professional service ...
(Date:8/19/2014)... LunaDress, a popular supplier of fashionable wedding, bridesmaid, ... now providing a discount of up to 67% on ... white prom outfits are available in different necklines; ladies ... , There are over 400 cheap white prom dresses ... offer is valid until August 29, 2014. The discounted ...
(Date:8/19/2014)... Recently, UWDress.com, a professional company of women’s dresses ... plus size formal evening dresses . Additionally, the firm has ... At the moment, all of them can be ordered at ... be valid until August 27, 2014. , The company ... designers believe that women of all shapes can be graceful ...
(Date:8/19/2014)... Recently, iFitDress.com,a leading online supplier of ... its new collection of pewter evening dresses . ... company’s global market. Each item is carefully made with ... spokesman, customers that have specific requirements can also order ... the brand new items are offered at discounted prices, ...
Breaking Medicine News(10 mins):Health News:2014 Bohemian Dresses Now for Sale at Skmen.com 2Health News:High Quality Canada Goose Solaris Parkas For Sale At CanadaGooseJackor.nu 2Health News:Popular Supplier LunaDress Providing an Exclusive Assortment of White Prom Dresses at a Discount of Up to 67% 2Health News:Cheap Plus Size Formal Evening Dresses Announced By UWDress.com 2Health News:Discounted Pewter Evening Dresses For 2014 Unveiled By Company iFitDress.com 2
... boost survival, German study shows , MONDAY, June ... performing radical hysterectomy in early-stage cervical cancer patients ... tumor recurrence, a German study shows. , The ... modified version of traditional radical hysterectomy. But this ...
... Plan Takes Holistic Approach in Seeking New Solutions to Improve ... Calif., June 1 More than 200 physicians and nurses ... to address a myriad of issues surrounding geriatric care in ... dementia and prostate cancer to more process-oriented issues such as ...
... 1, 2009) The latest advances in polyp detection, ... colonoscopy will be presented today at Digestive Disease Week ... size and type of polyps detected during colonoscopy and ... insight into the recommended frequency of follow-up preventive colonoscopy. ...
... heartbeat can indicate distress, but currently there is no ... when it could be too late to prevent serious ... system developed by an MIT scientist and colleagues including ... fetal heartbeat. The additional researchers are from the Institut ...
... , - John Hancock AnnuityNote Variable Annuity offers a simplified ... Market participation with downside protection , , - Simple ... John Hancock today announced the launch of a new retirement ... income to a broader market beyond the reach of traditional ...
... and the Alzheimer,s Association Support Award to Recognize Critical Role ... N.J., June 1 Eisai Inc., ... Alzheimer,s disease and their caregivers across America to nominate local ... A lzheimer,s. R ecognition of E xcellence.) Pharmacy ...
Cached Medicine News:Health News:Physicians Join With National Healthcare Leaders to Explore New Ways to Enhance Geriatric Care in America 2Health News:Physicians Join With National Healthcare Leaders to Explore New Ways to Enhance Geriatric Care in America 3Health News:New research identifies more effective tools for detection of colorectal cancer 2Health News:New research identifies more effective tools for detection of colorectal cancer 3Health News:New research identifies more effective tools for detection of colorectal cancer 4Health News:New research identifies more effective tools for detection of colorectal cancer 5Health News:New research identifies more effective tools for detection of colorectal cancer 6Health News:New research identifies more effective tools for detection of colorectal cancer 7Health News:MIT: New system monitors fetal heartbeat 2Health News:MIT: New system monitors fetal heartbeat 3Health News:John Hancock Launches New Retirement Income Solution 2Health News:John Hancock Launches New Retirement Income Solution 3Health News:John Hancock Launches New Retirement Income Solution 4Health News:John Hancock Launches New Retirement Income Solution 5Health News:Call for Nominations for the 2009 C.A.R.E. Pharmacy Award 2Health News:Call for Nominations for the 2009 C.A.R.E. Pharmacy Award 3
(Date:8/18/2014)... , August 19, 2014 Elbit ... EMITF ) announced today that Elbit Medical Technologies ... Company in which it holds approximately 86% of the ... Cell Ltd., in which Elbit Medical holds approximately 30.8% ... majority of Gamida Cell,s shareholders (including Elbit Medical), signed ...
(Date:8/18/2014)... , August 19, 2014 ... cell expansion technologies and therapeutic products, announced today that it ... Pharma AG  ( " Novartis " ... $35 million in Gamida Cell and in return will receive ... The option is exercisable for a limited period of time ...
(Date:8/18/2014)... YORK , Aug. 18, 2014 /PRNewswire/ ... research report is available in its catalogue: ... Biopharmaceutical Markets ... be categorized into three types: chromatography, membranes/filters ... products is increasing and fueling growth of ...
Breaking Medicine Technology:Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 2Elbit Imaging Announces Gamida Cell Signs Option and Investment Agreements with Major Pharmaceutical Company 3Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 2Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 3Gamida Cell Announces Investment and Option Agreement with Major Pharmaceutical Company 4Bioseparation Systems for Global Biopharmaceutical Markets 2Bioseparation Systems for Global Biopharmaceutical Markets 3Bioseparation Systems for Global Biopharmaceutical Markets 4Bioseparation Systems for Global Biopharmaceutical Markets 5Bioseparation Systems for Global Biopharmaceutical Markets 6Bioseparation Systems for Global Biopharmaceutical Markets 7Bioseparation Systems for Global Biopharmaceutical Markets 8Bioseparation Systems for Global Biopharmaceutical Markets 9Bioseparation Systems for Global Biopharmaceutical Markets 10Bioseparation Systems for Global Biopharmaceutical Markets 11Bioseparation Systems for Global Biopharmaceutical Markets 12
... Cempra Pharmaceuticals today announced results from its Phase ... tolerability of oral administration of our fourth generation ... with oral levofloxacin for the treatment of community-acquired ... CEM-101 demonstrated efficacy comparable to levofloxacin and a ...
... Sept. 15, 2011 Reportlinker.com announces that ... in its catalogue: Global ... http://www.reportlinker.com/p0240543/Global-Blood-Glucose-Test-Strips-Market-2010-2014.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... Test Strips market to grow at a ...
Cached Medicine Technology:Cempra Announces Comparable Efficacy of Oral Solithromycin (CEM-101) Compared with Levofloxacin in Phase II Clinical Trial in Patients with Community-Acquired Bacterial Pneumonia (CABP) 2Cempra Announces Comparable Efficacy of Oral Solithromycin (CEM-101) Compared with Levofloxacin in Phase II Clinical Trial in Patients with Community-Acquired Bacterial Pneumonia (CABP) 3Global Blood Glucose Test Strips Market 2010-2014 2
... EDTA K2 / gel tubes are ... for molecular diagnostics and for viral ... whole blood remain stable at room ... For optimal results, it is recommended ...
... offered as either EDTA K2 or ... calcium ions and therefore blocks the ... in an EDTA anticoagulated blood sample ... hours. EDTA tubes are for the ...
... is a ubiquitous enzyme that catalyzes ... is also the specific protein that ... immunofluorescence (EMA) tests (Bio-Rad catalog number ... serologic tests are highly sensitive and ...
... blood oximeters provide cardiologists with critical ... a patient's blood. The Oxicom series ... over a half-million saturation samples measured ... cost-effective oxygen saturation readings in less ...
Medicine Products: