Navigation Links
Gene Studies Could Point to New Alzheimer's Treatments
Date:4/25/2013

THURSDAY, April 25 (HealthDay News) -- Insight into genes that play a key role in disrupting immune system pathways in the brains of people with Alzheimer's disease could offer a potential target for new drugs against the disease, two new studies show.

"Defining the precise steps of the inflammatory response crucial to causing Alzheimer's disease has been elusive. We are pleased to discover these novel insights into that process," Bin Zhang, lead author of one of the studies and an associate professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai in New York City, said in a school news release.

In the study, Zhang's team analyzed brain tissue samples from deceased Alzheimer's patients, as well as healthy people who had died. By measuring the activity level of thousands of genes in these tissue samples, the team identified which gene networks are disrupted in diseased brains.

Specifically, their analysis pinpointed the important role of a gene expressed in immune cells called microglia, which clean up debris and destroy pathogens in the brain.

This gene, called TYROBP, is overactive in the brains of Alzheimer's patients and plays a major role in disrupting the activity of many other genes that control microglia activation, according to the study, which was published April 25 in the journal Cell.

"As a next step, we will evaluate drugs that impact [this] pathway as potential therapies for the disease," Zhang said. "This discovery enables us to design more specific compounds that target these key steps precisely, in contrast to existing anti-inflammatory drugs that may be less ideal for hitting this target."

Another study, published online April 25 in the journal Neuron, may have uncovered another genetic clue to Alzheimer's disease.

Researchers looked at brain samples from deceased Alzheimer's patients and found that higher activity of a gene called CD
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New studies prove lethal link between alcohol, weight
2. Experimental Drug for Hepatitis C Promising, Studies Show
3. New studies explore mangos potential health-affirming properties
4. Pancreatic Cancer Correlation to Type 2 Diabetes Drugs Januvia and Byetta, New Studies Find Possible Connection
5. 2 landmark studies report on success of using image-guided brachytherapy to treat cervical cancer
6. Hard Physical Labor May Boost Risk of Heart Disease, Stroke: Studies
7. Penn State to Offer Human Development and Family Studies Degree Online
8. WriteResult Selected for Irritable Bowel Syndrome Studies
9. New Studies further support the use of Vitamin B6 for Fat Loss
10. Complementary and alternative medicine studies take center stage at EuroHeart Care
11. GW researcher studies the dangerous effects of cocaine on HIV patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Studies Could Point to New Alzheimer's Treatments
(Date:1/22/2015)... City, Florida (PRWEB) January 22, 2015 IsoComforter, ... cold therapy machine with patented IsoTube design to treat specific ... has introduced the most progressive and easy to use patented ... treat post-operative and sports related orthopedic and muscle injuries. ...
(Date:1/22/2015)... DC (PRWEB) January 22, 2015 Payday ... in vulnerable communities and cause financial distress to the ... by analysts at Howard University’s Center on Race and ... dollars in economic activity, payday loans at the same ...
(Date:1/22/2015)... York, NY (PRWEB) January 22, 2015 As ... of overall health care gains momentum worldwide, Rev. Eric ... HealthCare Chaplaincy Network (HCCN), will be the keynote ... spiritual care in Israel’s public health system. , The conference, ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Compare-autoinsurance.org has released a ... insured by an auto insurance policy . , Some ... policy. Clients should check the newly released blog post to see ... cars and dangerously damaged vehicles are some of the cars that ...
(Date:1/22/2015)... 2015 Step into a macabre world ... Museum of Virginia. Wicked Plants, the Museum’s latest featured ... 75 poisonous, carnivorous and diabolical plants inside of a ... uncover the biochemical, physical and neurological processes between botanicals ...
Breaking Medicine News(10 mins):Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... Cancer Society has selected Indian ministry of health and ... for its "unrelenting stance on health promotion and tobacco ... Ramadoss will receive the award at a ceremony during ... a ministry statement said. ,The award has ...
... Indian Siamese twins are doing well and are expected to be ... June 21 at the Arwyp Medical Centre here, are healthy and ... are healthy," a report in the Post newspaper quoted Wian Stander, ... who are joined above the ear, were born by Caesarean section ...
... cells, seven banks of umbilical cord blood are coming up ... in Gurgaon this// month. ,Cryobanks India, a joint venture ... by Ravi Jaipuria, will invest Rs.1 billion to build the ... is a leader in the collection, processing and banking of ...
... that was smuggled into the United States was found in ... past month. Michigan health// officials have been trying to trace ... no sign that the frozen poultry, some even packed with ... virus. ,State officials, however has said that no ...
... Corners region of the United States (where Ariz., N.M., Colo. ... outbreak this year than in 2005//, say scientists at Johns ... ,They also warn that parts of southern Colo. and ... Corners region--are at increased risk in 2006. ,The ...
... cord dysfunction (VCD) – an involuntary functional disorder during ... a long-term study published in the current issue of ... of the American College of Allergy, Asthma and Immunology ... Pulmonary Division at the University of Iowa College of ...
Cached Medicine News:Health News:First Cord Blood Bank in North India to be Opened in Gurgaon 2Health News:Increased Risk of Hantavirus Forecast for U.S. Southwest 2Health News:Two Distinct Types of Vocal Cord Dysfunction Identified 2
(Date:1/23/2015)... FORT MYERS, Fla. , Jan. 23, 2015  Today ... approval of Novartis, Bexsero® for the prevention of ... to 25. Bexsero and Pfizer,s vaccine Trumenba®, which received ... in helping prevent this devastating disease. ...
(Date:1/23/2015)... A lot of discussion in the medical community revolves ... injuries, or conditions. As medical science advances, doctors and surgeons ... that they consider to be more cutting edge. Yet, when ... method of treatment that stands out as the best solution ...
(Date:1/23/2015)... DES MOINES, Iowa , Jan. 23, 2015  The Partnership to ... Iowa health care leaders and a new study ... prescription medications. The PFCD is a nationwide coalition working to educate ... The research released at the Capitol was focused on how the ...
Breaking Medicine Technology:The National Meningitis Association (NMA) Applauds FDA Approval of Second Vaccine To Protect Against Serogroup B Meningococcal Disease 2No One-Size-Fits-All Remedy for Hernia Correction 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3
The Prism Exophthalmometer provides precise measurement of patient's exophthalmos....
The first daily disposable lens affordable enough for full time wear....
... Magellan Mapper connects via a ... or desktop computer featuring Windows ... state of the art corneal ... bright ring projection and easy ...
... CT System combines sophisticated analysis and ... user-friendly platform. The ATLAS is ideal ... pathology detection and corneal refractive surgery ... comes standard with the Advanced Refractive ...
Medicine Products: