Navigation Links
Gene Signature May Predict Recurrence of Lung Cancer
Date:5/16/2008

Could help docs determine who would benefit most from chemo after surgery, study says

FRIDAY, May 16 (HealthDay News) -- A panel of 15 genes may help determine which patients with early-stage non-small cell lung cancer will experience a recurrence and, therefore, benefit the most from chemotherapy, a new study shows.

By extension, the same genetic signature may also identify patients with less aggressive forms of the cancer who would be able to forego chemotherapy.

"Using this signature, we can identify up to 30 to 40 percent of stage I patients who might benefit from post-surgery chemotherapy and maybe up to 30 to 40 percent who might not benefit," said study author Dr. Ming Tsao, who will present the finding June 1 at the American Society of Clinical Oncology (ASCO) annual meeting, in Chicago. "The idea is that this could potentially supercede staging, although we definitely need more studies. [The information] is not immediately useful."

Previous trials have shown a benefit for stage I and II non-small cell lung cancer patients who received chemo after surgery. But, so far, the benefit has been confined mostly to stage II patients.

Even so, the distinction is not clear-cut. Some 30 percent of stage I patients who don't get added chemotherapy will die of a disease recurrence, and it's also possible that some stage II patients might not need chemotherapy after surgery.

"The goal of this study was to identify the genetic characteristics that could potentially be used to predict more precisely the likelihood of clinical outcomes, so those who need post-surgery chemo should get it and those who do not need it do not get it," explained Tsao, who is professor of laboratory medicine at the University of Toronto and a senior scientist at Princess Margaret Hospital in Toronto.

Gene expression profiling was performed on frozen tumor tissues from 64 patients as part of a follow-up analysis of
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. 24 Hour Fitness Partners With Derek Jeter to Launch Signature Sports Clubs in New York City
2. Chemical signature of manic depression discovered by scientists
3. Avamere Health Systems Announces New President of Signature Home Health
4. Emmy(R)- and Golden Globe(R)-Nominated Actress Marcia Cross and Lifetime Television Deliver 20 Million Online Petition Signatures to Capitol Hill to Urge Congress to Stop Drive-Through Mastectomies
5. Hays AG Integrates Authentidate(R) Signature Solution for Electronic Invoicing
6. New neuroimaging study identifies brain signature for cigarette cravings
7. APHA Urges President Bush Not To Veto CHIP; Were Only One Signature Away from Protecting the Health of Our Children
8. Gene signature spells poor outcome
9. Protein predicts Gleevec resistance in gastrointestinal tumors
10. Biomarkers Predict Heart Deaths
11. Study shows gene variations may predict risk of breast cancer in women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Signature May Predict Recurrence of Lung Cancer
(Date:9/2/2014)... News) -- The quality of Americans, diets has improved ... the rich and poor is growing, a new study ... to date that the extensive efforts by many groups ... some payoff, but it also indicates that these efforts ... doctoral student in the department of nutrition at the ...
(Date:9/2/2014)... Amy Norton HealthDay Reporter , ... want to lose weight and boost their heart health, cutting ... a new study suggests. In a small clinical trial ... a low-carbohydrate diet lost more weight over a year than ... bigger improvements in their cholesterol and triglyceride levels, the research ...
(Date:9/2/2014)... Philadelphia, PA (PRWEB) September 02, 2014 ... Magee Rehabilitation Hospital returns on September 19 at The ... Hill, Pennsylvania. Over the past 25 years, the Classic, ... more than $12 million for programs and services designed ... at Magee Rehabilitation Hospital. , “The Segal Classic ...
(Date:9/2/2014)... 02, 2014 North America Resectoscopes ... Market Outlook to 2020? provides key market data ... provides value, in millions of US dollars, volume ... within market segments –,     Rigid ... Reusable) Electrodes and Bipolar (Disposable and Reusable) Electrodes). ...
(Date:9/2/2014)... 02, 2014 Humility of Mary Health Partners ... at St. Elizabeth Health Center, 1044 Belmont Ave. , The ... more than 200 common health problems as well as tips ... injury, and advice on when to seek medical attention. ... in the Youngstown Room; the evening session runs from 5:30 ...
Breaking Medicine News(10 mins):Health News:Quality of U.S. Diet Improves, Slightly 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 3Health News:The 25th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 3Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 4Health News:HMHP Offers ‘Health at Home’ Workshop 2
... of the Johns Hopkins Children,s Center and Scott Sicherer of ... caution when ordering allergy tests and to avoid making a ... article, published in the January issue of Pediatrics , ... tool in recent years, and skin-prick testing, an older weapon ...
... Doheny HealthDay Reporter , FRIDAY, Dec. 23 (HealthDay ... imaging tests between diagnosis and surgery than they did in ... -- breast ultrasounds, MRIs and mammograms -- help doctors determine ... hassles and expense of care, the study says. ...
... News) -- Reindeer have lots to do this time of ... sleighs -- but despite all their frenzied activity they manage ... overheated, researchers have found. Now, Norwegian scientists have gained ... of reindeer as they exercised on solid ground. In ...
... 23 (HealthDay News) -- Obese people who have had surgery to ... of the disease or die from cancer within five years as ... the study, published in the Dec. 1 issue of the ... Rochester, Minn., suggested their findings could change the way some doctors ...
... FRIDAY, Dec. 23 (HealthDay News) -- The holiday season can ... take steps to ensure they stay healthy through this often ... is a cancer survivor and their ranks are growing. Many ... disease and its treatment, experts at the Fred Hutchinson ...
... , FRIDAY, Dec. 23 (HealthDay News) -- Parents of ... lifestyle changes that will benefits their kids, health, a ... efforts to combat the childhood obesity epidemic among Hispanic ... United States, said the researchers at University of Texas ...
Cached Medicine News:Health News:Memo to pediatricians: Allergy tests are no magic bullets for diagnosis 2Health News:Memo to pediatricians: Allergy tests are no magic bullets for diagnosis 3Health News:Breast Cancer Patients Face More Imaging Tests Today 2Health News:Breast Cancer Patients Face More Imaging Tests Today 3Health News:Study Shows How Busy Reindeer Keep Their Cool 2Health News:Obesity Linked to Higher Esophageal Cancer Death Rates 2Health News:Cancer Survivors Should Take Steps to Keep Healthy During Holidays 2Health News:Parents May Hold Key to Healthy Weight in Hispanic Kids 2
(Date:9/2/2014)... SEATTLE , Sept. 2, 2014 /PRNewswire/ ... company committed to the development and commercialization ... today announced an update on corporate and ... structure, commitment for future funding, ongoing clinical ... In corporate news, Chief Executive Officer ...
(Date:9/2/2014)... , Sept. 2, 2014  MEI Pharma, Inc. ... focused on the clinical development of novel therapies ... enrollment in a randomized Phase II clinical trial ... combination with azacitidine in patients with previously untreated ... placebo-controlled, double-blind study enrolled a total of 108 ...
(Date:9/2/2014)... Sept. 2, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... three drugs in its lipid franchise were highlighted in ... (ESC) Congress in Barcelona Spain . ... designed to provide effective and safe therapeutic options to ... of one commercialized drug and several other drugs in ...
Breaking Medicine Technology:VentiRx Pharmaceuticals Provides Corporate and Clinical Update 2VentiRx Pharmaceuticals Provides Corporate and Clinical Update 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 4Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 2Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 3Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 4Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 5
... CHICAGO, May 25, 2012  Dallas entrepreneur Clayton Redmon has ... Black Enterprise . (Photo: http://photos.prnewswire.com/prnh/20120525/DA13928 ) ... StreamVenue Healthcare , was among three ... Business Awards, People,s Choice Award presented at the ...
... PARSIPPANY, N.J., May 25, 2012  Watson Pharmaceuticals, Inc. (NYSE: ... company, announced today that Siggi Olafsson, Watson,s President of ... the Company,s business at the Jefferies 2012 Global Healthcare ... Time at the Grand Hyatt in New York, New ...
Cached Medicine Technology:StreamVenue Healthcare CEO Named People's Choice Winner 2Watson to Present at the Jefferies 2012 Global Healthcare Conference 2
... diagnostic capabilities combined with ease of use ... in its class. Ideal for office or ... system for Uroflowmetry, cystometry, leak point pressure, ... are available which make the OM-5 flexible ...
The Duet EnCompass Pelvic Floor Diagnostic System is the only equipment specifically designed to perform urodynamics, anorectal manometry, EMG and pudendal nerve latency studies on a single software ...
... The Corkscrew FT II (fully threaded) is ... designed to be inserted flush with the ... and anchor stability. The full thread design ... anchors with protruding eyelets. Especially advantageous when ...
... Corkscrew Parachute Tissue Anchor allows one step fixation ... ideal for arthroscopic knotless rotator cuff repair in ... has an outside thread diameter of 5 mm ... #2 FiberWire suspension sutures securely hold a thin, ...
Medicine Products: