Navigation Links
Gene Signal presents data at ARVO 2012 showing topical aganirsen is active in retinal disease
Date:5/8/2012

Fort Lauderdale, FL, USA and Lausanne, Switzerland, May 8, 2012 Gene Signal, a company focused on developing innovative drugs to manage angiogenesis based conditions, today announced that positive data from a study of aganirsen (GS-101, eye drops) in a nonhuman primate model of choroidal neovascularization has been presented at the 2012 ARVO Annual Meeting in Fort Lauderdale, Florida. Topical administration of aganirsen was found to inhibit neovascular growth and leakage in this model and strongly suggests a role for the drug candidate in human retinal neovascular diseases such as wet age-related macular degeneration (AMD) and ischemic retinopathy. Gene Signal's aganirsen is an antisense oligonucleotide that is expected to complete a phase III trial for the treatment of progressive neovascularisation in the cornea in 2012. Clinical studies in retinal diseases are schedule to begin during the second quarter 2012.

"This study demonstrates the ability of aganirsen to address neovascularization formation in the retina by inhibiting the expression of the angiogenic protein IRS-1. Importantly, this is achieved without affecting normal vascularisation," noted Dr. Matthew Lawrence of RxGen, Inc, who presented the data. "With the demand for new, effective antiangiogenic agents that are easier to use in the treatment of several eye diseases growing, we believe these data strongly support a role for aganirsen."

Aganirsen blocks pathological neovascularization by inhibiting IRS-1. Clinical studies to date have shown that aganirsen is able to safely and effectively inhibit the development of progressive corneal neovascularization secondary to infectious keratitis or chemical burns both of which could lead to corneal graft replacement.

"A topical agent for neovascular disease would revolutionize treatment. There is a huge unmet need for many opthalmological diseases including AMD, ischemic retinopathy and certain forms of glucoma," noted Eric Viau
'/>"/>

Contact: Mike Sinclair
msinclair@halsin.com
44-207-318-2955
Halsin Partners
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Gatekeeper of brain steroid signals boosts emotional resilience to stress
2. Lightheadedness Upon Standing Could Signal Heart Risk
3. Kids Penicillin Allergy May Not Signal Other Drug Reactions
4. Cell signaling discovery provides new hope for blood disorders
5. Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells
6. Cell signaling key to stopping growth and migration of brain cancer cells
7. Impaired quality of life: A warning signal after oesophageal cancer surgery
8. Changes in Cerebrospinal Fluid May Signal Early Alzheimers
9. Thinner Brains Could Signal Alzheimers, Study Suggests
10. Holiday Blues May Signal Depression
11. Jump in Resting Heart Rate Might Signal Higher Death Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... has risen dramatically in Western societies. One frequently cited ... and have fewer infections than previous generations, thereby delaying ... researchers at Sahlgrenska Academy, University of Gothenburg, monitored children ... the immune system in relation to allergic disease. All ... Vstra Gtaland Region, half of them on farms that ...
(Date:7/8/2014)... Restoration has been awarded up to $15 million by ... four -year project aiming to help brain-injured people restore ... neurosurgery, engineering, neurobiology, psychology and physics will collaborate to ... the brain. , Memory is the process in which ... store it and retrieve it. Certain types of illnesses ...
(Date:7/8/2014)... hygiene rates were found to be three times higher ... there were no auditors present, according to a study ... The study, titled, "Quantification of the Hawthorne effect in ... a retrospective cohort study," published today on-line in the ... author Dr. Jocelyn Srigley, who did the study as ...
(Date:7/8/2014)... have increased risks of dying at a young age ... stroke, diabetes, and kidney and liver diseases, according to ... large studies of people from three countries. The study, ... part of the National Institutes of Health, found that ... dramatic reduction in life expectancy compared with people of ...
(Date:7/8/2014)... Military physicians will soon pick up joysticks instead of ... with serious health threats. , James Gerard, M.D., a professor ... grant from the Department of Defense Office of Naval ... a video game that will train physicians on pediatric emergency ... use one of the most popular tools gaming ...
Breaking Medicine News(10 mins):Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3Health News:NCI study finds extreme obesity may shorten life expectancy up to 14 years 2Health News:Save, don't kill: SLU pediatrician to develop educational video game for training military physician 2
... Announce the Houston Tackles Autism Campaign, HOUSTON, ... running back Ahman Green, representatives from Reliant Energy, ... are holding a,news conference to raise awareness about ... book Playing Together: Tips from the Pros. ...
... Also Renews Commitment to Darfur, STAMFORD, Conn., Oct. ... more than $7,billion in aid to people in need ... AmeriCares President and CEO Curt Welling announced the milestone ... held at Westchester County Airport on Saturday., "I ...
... with their doctors , , MONDAY, Oct. 15 (HealthDay News) ... implantable defibrillators -- voluntarily stopped distribution of Sprint Fidelis ... wires could fracture, potentially triggering cardiac events. , The ... implanted defibrillators wondering what to do next. , But ...
... 15 Today, Easter Seals awarded members,of state ... Easter Seals annual convention currently being held in ... to honor public,officials -- elected and appointed -- ... for people with disabilities, and for all. ...
... ,Family,Matters, Study, BOSTON, Oct. 15 It could be ... look as if they,re,turning away from their family in favor ... A lot., A study led by Simmons School of ... importance to adolescents that they feel,valued by their family, and ...
... Calif., Oct. 15 Digirad Corporation,(Nasdaq: DRAD ... systems,and services to physicians, offices, hospitals and imaging ... Deloitte,s Technology Fast 50 Program,for San Diego. The ... and life sciences companies in the,San Diego area ...
Cached Medicine News:Health News:Reliant Energy, Houston Texans' Ahman Green and Matt Schaub Team to Hold News Conference, Book Signing to Raise Awareness about Autism 2Health News:Reliant Energy, Houston Texans' Ahman Green and Matt Schaub Team to Hold News Conference, Book Signing to Raise Awareness about Autism 3Health News:AmeriCares Passes $7 Billion Mark in Aid Distributed 2Health News:Defib Wire Warning Shouldn't Worry Most Users: Experts 2Health News:Defib Wire Warning Shouldn't Worry Most Users: Experts 3Health News:Defib Wire Warning Shouldn't Worry Most Users: Experts 4Health News:Easter Seals Awards State and Municipal Public Officials With 2007 Outstanding Advocate Awards 2Health News:A Best-Kept Secret of Your Teen: They Really Do Care What You Think, Simmons College Study Shows 2Health News:Digirad Corporation Named to Deloitte Technology Fast 50 2Health News:Digirad Corporation Named to Deloitte Technology Fast 50 3
(Date:1/15/2014)... Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... Symphony® CGM System as a non-invasive, wireless continuous glucose ... , Executive Chairman and Interim CEO of Echo Therapeutics, ... Annual Equity Conference. Mr. Doman will ...
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
(Date:1/14/2014)... Jan. 14, 2014 HeartWare International, Inc . ... less invasive, miniaturized circulatory support technologies that are revolutionizing ... it expects revenues for the fourth quarter of 2013 ... revenues to approximately $208 million. "Our full-year ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4
... OAKS, Calif., April 13, 2011 Amgen (NASDAQ: ... first quarter financial results on Wednesday, April 20, 2011 after ... be followed by a conference call with the investment community ... Amgen will be Kevin Sharer, chairman and chief executive officer, ...
... 13, 2011 Perrigo (Nasdaq: PRGO;TASE) today announced that ... TEVA ), has received final OTC approval to sell ... tablets; the generic equivalents of Sanofi-Aventis, Allegra 60 mg ... for these products, and Teva and Sanofi-Aventis have settled ...
Cached Medicine Technology:Amgen Announces Webcast of 2011 First Quarter Financial Results 2Perrigo Partner Teva Receives Final OTC Approval for Sales and Distribution of Fexofenadine HCl 60 mg and 180 mg Tablets 2Perrigo Partner Teva Receives Final OTC Approval for Sales and Distribution of Fexofenadine HCl 60 mg and 180 mg Tablets 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: