Navigation Links
Gene Shortage Might Lead to Shorter Height, Study Says
Date:11/23/2011

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, Nov. 23 (HealthDay News) -- Tall or short, it's long been known that genes account for much of a person's height. Now, scientists have found that short people actually might be missing copies of certain genes, which can leave them significantly smaller than average.

Studying DNA from more than 11,000 children and adults, an international team of researchers learned that those of short stature -- defined roughly as falling into the shortest 2.5 percent of their peer group -- had an excess number of rare deletions, or missing copies, of specific genes. Thus far, most research into genes and height has centered on identifying variations in common genes instead of an absence of others, study author Dr. Joel Hirschhorn said.

"We were a little bit surprised, since we didn't really know what we would find going in [to the study] and whether we would see enough of an effect," said Hirschhorn, a professor of genetics at Children's Hospital Boston. "We were trying to figure out what's the underlying genetics of height and things like it, and this is a class of variation less well studied."

The study is published in the December issue of the American Journal of Human Genetics.

Common gene variants linked to height explain only about 10 percent of the variation in adult height, Hirschhorn said, but perhaps half of such variation might eventually be explained by some of the differences his team studied.

First analyzing the DNA of more than 4,400 children whose genetic material was collected for other purposes, the researchers observed that many more CNVs or "copy-number variants" -- in this case, fewer copies of a gene -- were present in those of short stature.

Extending the findings to a larger, population-based group of nearly 6,900 African Americans, the scientists again found that shorter participants had an excess of such missing gene copies. These deletions would typically be inherited from one's parents, but not always, Hirschhorn said.

"Usually [researchers] look at variants one at a time, but this is a cumulative-effect type of variation," said Hirschhorn, also a senior associate at the Broad Institute, a biomedical research organization in Cambridge, Mass.

Several limitations might affect the validity of the study results, the authors acknowledged. One is the fact that children whose DNA was evaluated had initially undergone genetic analysis for other reasons such as developmental delays, autism spectrum disorders and multiple birth defects. So it's possible that those with many missing gene copies are likelier to have conditions leading to poor growth, the study said, but the replication of results in a more representative population suggests the findings can be generalized to others.

More information

Stanford University School of Medicine has more about inherited traits.

SOURCES: Joel N. Hirschhorn, M.D., Ph.D., professor of genetics, Children's Hospital Boston, senior associate, Broad Institute, Cambridge, Mass.; December 2011, American Journal of Human Genetics


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Obama Acts to Ease U.S. Drug Shortages
2. $7.2 million project will address a national shortage of health-care workers in Liberia
3. Drug Shortages Even Worse This Year: FDA
4. Homegrown solution for physician shortage described in Academic Medicine
5. Allowing part-time surgeons may help address workforce shortage
6. Cancer Drug Shortages Getting Worse, FDA Says
7. ADHD Drug Shortage Has Patients, Parents Scrambling
8. Shortage of Anesthetics Reported
9. IU-Regenstrief programs targeted to alleviate shortage of health IT workforce
10. Report Highlights Shortage of HIV Care Providers in U.S.
11. House leaders told some cuts in budget resolution could increase shortage of primary care physicians
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Shortage Might Lead to Shorter Height, Study Says
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
Breaking Medicine Technology: