Navigation Links
Gene Plays Key Role in Clubfoot
Date:10/27/2008

Finding could lead to tests, therapies, experts say

MONDAY, Oct. 27 (HealthDay News) -- The first gene linked to clubfoot has been identified by researchers at the Washington University School of Medicine in St. Louis, who analyzed the DNA of 35 extended family members of a male infant with clubfoot.

Through their analysis, the study authors concluded that a mutation in a gene called PITX1 -- which is critical for early development of lower limbs -- was responsible for the condition. The mutation was found in all 13 affected family members and in three carriers who showed no clinical symptoms.

Other genes may also play a role in clubfoot, but this finding is an initial step toward improved genetic counseling and the development of new therapies, the researchers said. The study appears in the Nov. 7 issue of the American Journal of Human Genetics.

"To our knowledge this report is the first evidence for PITX1 mutation in human disease," Dr. Christina Gurnett, an assistant professor of neurology, of pediatrics and of orthopedic surgery, said in a university news release. "Once we identified the mutation, we proved that all of the individuals in this family with lower extremity malformations also have the mutation. Having large families to work with is very helpful in genetic research."

Clubfoot, which affects about one in 1,000 newborns, is "a complex disorder meaning that more than one gene as well as environmental factors will be discovered to play a role in its [cause]," study senior author and clubfoot specialist Dr. Matthew Dobbs, an associate professor of orthopedic surgery, said in the news release.

In about 80 percent of clubfoot cases, the cause is unknown, while a familial link plays a role in about 25 percent of cases, according to background information about the study. Males are twice as likely as females to have clubfoot, which occurs more often in the right foot. About half of
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Laboratory at UI plays major role in diagnosing cancer
2. Environment plays key role in childrens readiness for school
3. Gene Plays Role in Risk of Autism
4. Heart-Shaped Light Displays on Blue Cross Blue Shield of Michigan Building Show Support for American Heart Month, National Wear Red Day
5. Study Spots Gene That Plays Role in Infertility
6. One Million PLAYSTATION(R)3 Users Participate in Folding@home Research Project
7. Gene plays Jekyll and Hyde in brain cancer
8. Gene Plays Jekyll-and-Hyde Role in Deadly Brain Cancer
9. Scientists solve structure of gene regulator that plays key role in cancer
10. Rare Gene Mutation Plays Role in Longevity
11. Price Plays Part in Perceived Power of Medication
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Plays Key Role in Clubfoot
(Date:3/26/2015)... March 26, 2015 Dr. Rod ... annual Dallas Rhinoplasty Symposium and has trained over ... the importance of evidence based medicine (EBM), that is, ... well conducted research. , "We often hear from ... and while we are certainly not trying to stifle ...
(Date:3/26/2015)... North American Seminars launches it new mobile website ... information regarding OT PT continuing education courses to the ... leader in live hands PT continuing education courses ... online continuing education courses. , Featured Live ... Clinicians Approach to Advanced Concepts in Examination and Treatment ...
(Date:3/26/2015)... 2015 The American College of Traditional Chinese ... topics of the DAOM Program as well as Marketing Basics ... will be hosted by Dr. Carla Wilson, who will give ... on how to prepare for the spring quarter. The webinar ... 27, April 1 and April 3. Attendees can log in ...
(Date:3/26/2015)... Doctors Scott Sullivan and Frank DellaCroce, Co-Founders of the ... the St. Charles Surgical Hospital (SCSH) in ... Surgical Oncologist Dr. William Karl Ordoyne has joined their ... surgical oncologist Alan Stolier, M.D., FACS and the team ... Sullivan, M.D., FACS; Chris Trahan, M.D., FACS; M. Whitten ...
(Date:3/26/2015)... Doylestown, PA (PRWEB) March 26, 2015 ... recruited a new team of nationally renowned scientists to ... hepatitis B, a move that nearly triples its research ... scientists focusing solely on hepatitis B and liver cancer ... Drs. Timothy Block, Jinhong Chang, Ju Tao Guo and ...
Breaking Medicine News(10 mins):Health News:Dr. Rod Rohrich Explores Evidence Based Innovations and Safety at the 32nd Annual Dallas Rhinoplasty Symposium 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 2Health News:North American Seminars Launches Healthclick.com, a New Mobile Ready Website, Providing CME Course Information to PT, PTA, OT and ATC's 3Health News:ACTCM Announces Upcoming Webinars 2Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 2Health News:Surgical Oncologist Joins Center for Restorative Breast Surgery and St. Charles Surgical Hospital 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 2Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 3Health News:Baruch S. Blumberg Institute Recruits World-Class Hepatitis B Scientists 4
... study published in the Lancet has revealed how British American ... strategy to mask the toxicity of the manufactured cigarettes. // ... of the company by Canadian researchers, it has been found ... nicotine under real life situations, while in documentation, it was ...
... at the University of Iowa Roy J. and Lucille A. ... (PET) technology can help // doctors gauge the response of ... and co-author Bruce Cheson, M.D., of the Lombardi Comprehensive Cancer ... usage of PET n gauging the response of the tumor ...
... service policy acceptance in schools it has been found ... directors' perceptions. // ,They have different ideas ... among key stakeholders addressing new wellness policy development mandated ... 2004. ,'Competitive foods are those sold ...
... respiratory illness as a result of breast-feeding, according to a ... belonging to the age group of 6 years to 24 ... They identified five groups, formula-fed only, full breastfeeding for ... months, full breastfeeding from four to less than six months, ...
... the wrong reasons. Blaming the government of apathy over the ... post of Chief Scientific Officer at the Department of Health, has ... vaccine adequately, despite a lurking fear of autism, as a probable ... it could turn out to be the worst disgrace in medical ...
... Health Grade, a health ratings company, the top 5 % ... to lower the risk of death to patients by ... risk of complications. //,Health Grades, as part of their ... in the United States. ,Death and complication rates for ...
Cached Medicine News:Health News:Clash of Difference of perceptions in food policy among Principals’ and Director 2
(Date:3/26/2015)... March 26, 2015 "Whether it,s our family, ... day." In a single sentence, Dr. ... officer at Pfizer,s Centers for Therapeutic Innovation ... fueling progress at America,s biopharmaceutical companies. ... with academia, patient foundations and the National Institutes of ...
(Date:3/26/2015)... 26, 2015 When they began experiencing ... PACS vendor their system would no longer be ... needed a better structured solution to support their ... due to its interface capabilities and its 2014 ... through to the hospital,s radiology department. Avreo,s experienced ...
(Date:3/26/2015)... 26, 2015 Zimmer Holdings, Inc. (NYSE and ... Advanced Bearing Technology with Vitamin E by celebrating ... earlier this month reported that, at 96 million cycles ... Bearing Technology featuring Vitamin E grafted highly crosslinked polyethylene ... rate reduction of 95 percent, with no cracking, delamination ...
Breaking Medicine Technology:Collaboration for Cures: Teaming Up to Advance Science and Save Lives 2Clinch Memorial Hospital Modernizes Workflow with Avreo interWORKS 2Zimmer Announces New Testing Milestone For Vitamin E Advanced Bearing Technology 2Zimmer Announces New Testing Milestone For Vitamin E Advanced Bearing Technology 3
... Ferring Pharmaceuticals Inc. today announced publication of one ... (tranexamic acid) tablets for cyclic heavy menstrual bleeding ... journal, Obstetrics & Gynecology .  The six-month ... blood loss from baseline, and improved health-related quality-of-life ...
... Oct. 6 AstraZeneca (NYSE: AZN ... at no cost to qualifying patients at the ... (Logo: http://photos.prnewswire.com/prnh/20091027/PH99766LOGO) (Logo: http://www.newscom.com/cgi-bin/prnh/20091027/PH99766LOGO) ... is an expansion of its AZ&Me™ Prescription Savings ...
Cached Medicine Technology:Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 2Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 3Obstetrics and Gynecology Publishes Data From Pivotal Phase 3 LYSTEDA Study 4AstraZeneca and the Sacramento County Pharmacy Provide Free Medicines to Eligible California Patients 2AstraZeneca and the Sacramento County Pharmacy Provide Free Medicines to Eligible California Patients 3
... One of the most innovative and ... Thermotherapy (WIT) provides an ideal solution for ... office. No other option provides a better ... The AquaTherm System heats, circulates, and maintains ...
... generally confirmed by a positive heterophil antibody test ... not indicated by the heterophil antibody test. ... percent of children. Detection and identification of ... the stage of EBV infection. Bio-Rad offers ...
... Every Bard® Biopsy Instrument and Needle is ... important goal: a large quality, reliable core ... performance, featuring ultra-sharp tips and polished surfaces ... selection of biopsy systems and needle sizes ...
... Used to obtain multiple core biopsies ... Quick-Core® Biopsy Needle design facilitates one-handed control. ... tissue sample. Beveled point stylet permits easy ... to surrounding tissue. Sharp cutting edge of ...
Medicine Products: