Navigation Links
Gene Network Sciences Announces Brain Cancer Collaboration With M.D. Anderson
Date:4/14/2009

CAMBRIDGE, Mass., April 14 /PRNewswire/ -- Gene Network Sciences, Inc. (GNS) today announced that it has entered into a research collaboration with The University of Texas M.D. Anderson Cancer Center aimed at the rapid translation of DNA sequence and clinical data from patients with glioblastoma, the most common and deadly form of brain cancer, into breakthrough discoveries leading to drugs and diagnostics. This collaboration will leverage the combination of groundbreaking genetic data and clinical oncology expertise from M.D. Anderson with supercomputers and advanced machine-learning software from GNS. Financial terms of the agreement were not disclosed.

The rich glioblastoma dataset produced by M.D. Anderson researchers, which includes genetic, genomic, and clinical endpoint data ("3-D Data"), will be analyzed using GNS's supercomputer-driven REFS(TM) (Reverse Engineering and Forward Simulation) software platform. These analyses are expected to generate models that enable the discovery of key genes, proteins and other molecular entities that together, as a network, causally drive glioblastoma disease progression, disease recurrence, and survival. The results from these projects will include the identification of new combination drug targets for disease and the development of diagnostics to determine appropriate individual patient treatments.

"There continues to be an urgent need for a more efficient translation of research into improved treatments for glioblastoma patients," said Dr. Kenneth Aldape, who led the M.D. Anderson glioblastoma research team that conducted the research that produced the data. "With its computational expertise and commercially tested REFS(TM) platform, GNS is well positioned to work with us to achieve the desired acceleration in the development of sorely needed effective treatments and diagnostics for this deadly disease."

The parties plan to transform this coherent clinical 3-D Data into computer models which link genetic alterations to changes in gene expression to progression-free patient survival times. This computer model, developed by using the REFS(TM) platform, is expected to unravel the complex genetic circuitry underlying glioblastoma and reveal novel drug targets and markers of response. These targets and markers may be used to identify the optimal single or combination drug therapy for a given patient's genetic alteration profile. The parties will utilize M.D. Anderson's clinical expertise to validate the discoveries and will work with strategic partners to make drugs and diagnostics stemming from these discoveries available to patients.

"GNS is excited to be working with one of the world's foremost research and clinical care institutions to rapidly translate lab bench research into bedside results," said Colin Hill, CEO of GNS. "Our collaborative work with M.D. Anderson is one of the first examples of applying next-generation machine-learning software and supercomputers to begin to realize the promise of personalized medicine."

About Gene Network Sciences

Gene Network Sciences (http://www.gnsbiotech.com/) is a leader in biosimulation with its ability to derive molecular mechanisms of drugs and diseases directly from molecular profiling and clinical data. Based in Cambridge, Massachusetts, and Ithaca, New York, GNS uses its REFS(TM) technology in pharmaceutical and clinical settings to rapidly turn combinations of genetic, genomic, and clinical measurements into models of disease progression and drug response. These models are then simulated to discover both new targets for drug intervention and genetic markers of drug response that allow patients who will respond to a given drug treatment to be matched to a particular clinical trial. By discovering how and why specific sets of genes and drug candidates impact human biology, GNS technology enables the rapid development of breakthrough drug and diagnostic products.

About M.D. Anderson

The University of Texas M.D. Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. M.D. Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. For four of the past six years, including 2008, M.D. Anderson has ranked No. 1 in cancer care in "America's Best Hospitals," a survey published annually in U.S. News & World Report.


'/>"/>
SOURCE Gene Network Sciences, Inc
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Access Innovations Provides Support Services for Agis Network
2. Womens World Banking Welcomes New Network Member From Tunisia
3. Internet TV Network for Personal Trainers is Launched
4. Quality Innovators to Network in Atlanta Sept. 19-21: Learn from Those Who Got It Right
5. Guardians Dental Network Experiences Double-Digit Growth
6. Chronic infection persists by targeting stromal cell network in lymphoid organs
7. The American Pain Foundation (APF) and The HealthCentral Network Collaborate to Develop Enhanced Internet Resources for People with Pain
8. Blue Care Network of Michigan Earns National Leadership Award for Chronic Disease Management
9. AT&T Offers Network Industry-First RFID Solution for Health Care Organizations
10. AT&T Establishes New Network Services for Leading Medical Liability Insurer
11. Portico Systems to Share Provider Network Management Best Practices at Institute for International Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... TopConsumerReviews.com recently awarded ... Eyeglasses . , Millions of individuals in the United States and Canada wear ... a way to both correct vision and make a fashion statement. Even celebrities use ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... inhaled drugs, announced today that it was added to ... its comprehensive set of U.S. and global equity ... an important milestone for Pulmatrix," said Chief Executive Officer ... of our progress in developing drugs for crucial unmet ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
Breaking Medicine Technology: