Navigation Links
Gene Mutations Seem to Make a Leukemia More Deadly
Date:11/10/2010

ntermediate-risk group, some of whom do poorly and some who don't, though scientists have been unable to figure out why.

"The purpose of this project was to sequence the genomes of many of the patients with intermediate risk to find mutations that are responsible for poor outcome so we can do a better job of treating them up front," Ley said.

The breakthrough in the project came after scientists decoded the genome of a woman who had died of AML and then compared that genome to the genome of her cancer cells.

For this paper, scientists report finding similar mutations in the DNMT3A (DNA methyltransferase 3A gene) gene in 22.1 percent of 280 other patients with AML.

The mutations were present in 34 percent of patients of intermediate risk but not all in patients with a favorable risk profile.

"It was a bonanza of mutations in this gene," Ley said, 34 in total.

And those with the mutations didn't do well, surviving for only about one year, compared to about three-and-a-half years in those without the mutation.

Those with the mutation also tended to fare better with bone marrow transplants, suggesting that this might be the first avenue of treatment for these patients.

Also, older patients did worse with the mutation. All 17 of patients over the age of 60 with the mutations had died by 18 months.

"We don't understand the mechanism yet," said Ley, who is hoping that other research groups will be able to validate the findings.

"This is another step toward getting a clearer picture of the biology involved in each patient's leukemia so we can better choose therapies for that specific patient and have the best chance to beat it," Rizzieri said.

More information

The Leukemia and Lymphoma Society has more on AML.

SOURCES: Timothy J. Ley, M.D., professor, medicine and genetics, Washington
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Seem to Make a Leukemia More Deadly
(Date:7/25/2014)... 2014 Innerspire, LLC ( http://www.innerspire.com ) ... as a Creative Enrollment Specialist. In this role, Greg ... as well as his accomplished design skills to further ... and to service the creative marketing needs ... work with small business owners and individuals looking to ...
(Date:7/25/2014)... 25, 2014 The American Brain Tumor ... Talent Development Trainer of Distinguished Events, and Corporate and ... American Cancer Society, will be joining the ABTA in ... Ward will oversee the roll out of a nationwide ... , The recently launched volunteer network will provide the ...
(Date:7/25/2014)... The American Brain Tumor Association (ABTA) today unveiled branding ... annual patient and family conference in Chicago. , “This ... as we – the first and now only national ... brain tumor research – extend our reach by engaging ... getting our materials and services into the hands of ...
(Date:7/25/2014)... “You have a brain tumor.” These five words ... loved ones across the U.S. every day. According to the ... typically met with confusion and uncertainty as families struggle to ... make critical decisions about a course of treatment. The shock ... a sense of isolation and a frantic and, far too ...
(Date:7/25/2014)... Chicago, IL (PRWEB) July 25, 2014 There ... tumor, and 500 diagnosed each day. Though when someone hears ... alone, confused and are unsure of the next step and ... is helping people figure out that next step by providing ... knows this more than Brian Olson, member of the ABTA’s ...
Breaking Medicine News(10 mins):Health News:Innerspire, LLC Continues National Expansion 2Health News:Innerspire, LLC Continues National Expansion 3Health News:Innerspire, LLC Continues National Expansion 4Health News:American Brain Tumor Association Recruits Director to Lead New Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 2Health News:American Brain Tumor Association Unveils Brand Identity for Newly Launched Volunteer Network 3Health News:American Brain Tumor Association to Expand Service Reach with Launch of Nationwide Volunteer Network 2Health News:American Brain Tumor Association to Expand Service Reach with Launch of Nationwide Volunteer Network 3Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 2Health News:American Brain Tumor Association Board of Directors Member Shares Story of Brain Tumor Survivorship 3
... , WEDNESDAY, Sept. 14 (HealthDay News) -- ... new research suggests that people who kick the habit ... from the University of Missouri found that smoking is ... (often being emotionally negative and anxious) among adults under ...
... Alexandria, Va., USA - The International and American ... proceedings from the 3rd AADR Fall Focused Symposium ... symposium was held November 12-13, 2010, in Washington, ... Symposium under the objective to provide networking opportunities ...
... Division of Pain Medicine in the Department of ... Neurological Institute have each received 2011 Medical & ... Institutions for these nationally competitive awards are reviewed ... comprised of leaders in the field. The ...
... likely than Caucasians to be not only diagnosed with head and ... answer isn,t a simple one, differences in lifestyle, access to care ... a new study from Henry Ford Hospital. The study also ... current smokers, one of the primary risk factors for head and ...
... , WEDNESDAY, Sept. 14 (HealthDay News) -- For ... on staff, "telestroke" may be a cost-effective option to ... say. Telestroke, or virtual stroke care, ... through two-way audio-video equipment. "In an era of ...
... The human papillomavirus (HPV) is more likely to be ... and those with private health insurance, according to a new ... also reveals that laryngeal cancer patients with Medicare, who tend ... HPV, suggesting that HPV infection may be closely tied to ...
Cached Medicine News:Health News:Quitting Smoking May Improve Personality, Study Suggests 2Health News:IADR/AADR publish proceedings from the AADR Fall Focused Symposium on Salivary Diagnostics 2Health News:Genetics, lifestyle provide clues to racial differences in head and neck cancer 2Health News:Genetics, lifestyle provide clues to racial differences in head and neck cancer 3Health News:Rural Stroke Victims May Benefit From 'Virtual' Care 2Health News:Gender, insurance type tied to HPV infection in laryngeal cancer patients 2Health News:Gender, insurance type tied to HPV infection in laryngeal cancer patients 3
(Date:7/24/2014)... July 24, 2014  Kinex Pharmaceuticals announced the receipt ... Company,s KX2-391 Ointment for the commencement of a Phase ... Company,s third IND to be allowed by the US ... is a synthetic, orally active and highly selective inhibitor ... promotes the induction of p53, G2/M arrest of proliferating ...
(Date:7/24/2014)...  The American Association for Homecare (AAHomecare) yesterday ... help address audit issues in the HME industry ... the information technology lead in shaping its HME ... billing and business management solutions for nearly 3,000 ... support this important initiative on behalf of all ...
(Date:7/24/2014)... Research and Markets  has announced the ... Product, Component, Application and Geography - Global Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 ... a moderate growth as the markets of the U.S. ... the saturation levels. The demand is expected to come ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 2Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 3Kinex Pharmaceuticals Announces Allowance of the Investigational New Drug (IND) application for KX2-391 Ointment by the United States Food and Drug Administration (FDA) 4Brightree Joins AAHomecare as Corporate Partner and IT Lead on HME Audit Key 2Machine Health Monitoring (Vibration Monitoring, Thermography, Ultrasound Emission, Lubricating Oil Analysis, Corrosion Monitoring, Motor Current Signature Analysis) Market - Forecast to 2020 2
... Mettler-Toledo International Inc. (NYSE: MTD ) today ... Life Sciences Conference in New York on Wednesday, September 22, ... webcast of the presentation, visit the investor relations page on ... of the webcast will be available for seven days. ...
... HeartWare International, Inc. (Nasdaq: HTWR ; ... circulatory support technologies that are revolutionizing the treatment of ... is scheduled to make an investor presentation at the ... 21, at 12:30 pm EDT.  The conference will be ...
Cached Medicine Technology:HeartWare to Present at the UBS 2010 Global Life Sciences Conference 2
Dust covers for a variety of Zeiss microscopes...
Inquire...
... An economical laboratory tissue culture microscope, ... to expand their applications. Olympus has taken ... the CKX41. Fluorescence can be used with ... images can be carried out on the ...
... Designed for the scientist who wants ... the TE2000E2 is a high precision Z-focus ... This makes it possible to expand ... sources and image outputs. A five-way ...
Medicine Products: