Navigation Links
Gene Mutations Seem to Make a Leukemia More Deadly
Date:11/10/2010

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Nov. 10 (HealthDay News) -- Researchers have pinpointed a gene with multiple mutations that seems to separate people who die quickly from acute myeloid leukemia (AML) from those who do not.

The findings, appearing in the Nov. 11 issue of the New England Journal of Medicine, could help identify which AML patients are the best candidates for more aggressive initial treatment. The insights might also provide a target for future therapies.

"We have to know the gene before we can design the targeted therapy, and we need to understand the mechanism," explained study senior author Dr. Timothy Ley, a professor of medicine and genetics at Washington University in St. Louis. "The mutations provide a new clue to find out how the mechanism might affect gene regulation in patients with these mutations. Hopefully, [additional studies] will tell us a lot more about how to think about reversing effects of mutations in patients with this disease."

"The whole idea is to move towards personalizing our health-care choices and to do that we have to better understand the pathways that lead to the development and progression of each person's cancer," added Dr. David Rizzieri, director of the hematologic malignancy program at Duke University. "This is a potential major step forward to better understanding the role of this molecular pathway in both the development and progression of AML."

AML is a cancer of the blood-forming cells, affecting about 13,000 Americans every year, 9,000 of whom will die.

Overall, only 20 percent of patients with AML will survive five years but there are three risk groups of patients, each of which confers a different prognosis.

"Favorable" risk patients tend to do better with standard therapy, while those with poor risk need to get a bone-marrow transplant when they go into their first remission, Ley explained.

Then there's the i
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Seem to Make a Leukemia More Deadly
(Date:9/19/2014)... Singulair, developed by Merck, is a ... D4 (LTD4). LTD4 belongs to the family of Cys-LTs, ... including mast cells and eosinophils, and which bind to ... that there are higher concentrations of Cys-LTs in the ... The production of CysLTs is increased in asthmatics, particularly ...
(Date:9/19/2014)... 2014 Follow us on ... for detection and quantification of the presence of ... by steady expansion in immunodiagnostics and technological advancements ... systems market has evolved remarkably well over the ... diabetes, cardio-vascular ailments, infectious diseases, allergy and cancer, ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Activz Whole-Food ... Greens Smoothie product, a new whole-food produce powder ... in Baltimore, MD. Activz Greens Smoothie is ... in one convenient – and absolutely delicious —Greens Smoothie. ... in Baltimore, MD. , The new ...
(Date:9/19/2014)... Leguminous plants are able to grow well in infertile ... humans. The reason for this is because most legumes ... can fix nitrogen in the air and then supply ... The plants create symbiotic organs called nodules in ... made it will adversely affect the growth of the ...
(Date:9/19/2014)... Group, Baltimore’s leading web development firm, has created and launched ... new site aligns the Catholic order of Brothers with their ... life of Gospel witness lived in community and to respond ... love to the people of the world in these times." ... which allows users to easily access information using a desktop, ...
Breaking Medicine News(10 mins):Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 2Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 3Health News:Singulair Asthma Market to 2023 – Etiology, Pathophysiology, Diagnosis & Treatment Overview in New Report Available at LifeScienceIndustryResearch.com 4Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 2Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 3Health News:Growing Preference for Non-Invasive Diagnostics Spurs Growth in the Global Immunoassay Systems Market, According to New Report by Global Industry Analysts, Inc. 4Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 2Health News:New Activz Greens Smoothie with 8 Organic Superfoods & More Launched at Natural Products Expo East 3Health News:Long-distance communication from leaves to roots 2Health News:Xaverian Brothers Partner with The Canton Group to Launch New Website 2
... By Amanda Gardner HealthDay Reporter , ... that derives fats and proteins from vegetable sources rather ... Comparing the two types of diets over two decades, ... reduced rates of death from cardiovascular disease and cancer, ...
... States must focus on conserving the use of antibacterial ... rising rates of antibiotic-resistant infections, according to an analysis ... of antibiotics is being depleted by resistance, which occurs ... no longer respond to widely-used treatments. Most proposals to ...
... The Endocrine Society released a new clinical practice guideline ... (CAH). The guideline features a series of evidence-based clinical ... guideline, published in the September 2010 issue of the ... JCEM ), a publication of The Endocrine Society, is ...
... methods, researchers at the University of California, San Diego ... spend significantly more time visually examining dynamic geometric patterns ... viewing pattern not found in either typical or developmentally ... that a preference for geometric patterns early in life ...
... psychotic disorders and living in urban areas appears to ... cities, according to a report in the September issue ... the JAMA/Archives journals. "There is a ... authors write as background in the article. "The clearest ...
... blood levels of chemicals used in the production of ... have elevated total and LDL cholesterol levels, according to ... of Pediatrics & Adolescent Medicine , one of the ... compounds known as perfluoroalkyl acidsincluding perfluorooctanoic acid (PFOA) and ...
Cached Medicine News:Health News:Low-Carb Diets Heavy on Meat May Raise Health Risks 2Health News:Pharmaceutical conservation key to slowing rise of antibiotic-resistant infections 2Health News:Pharmaceutical conservation key to slowing rise of antibiotic-resistant infections 3Health News:Experts recommend universal screening of newborns for congenital adrenal hyperplasia 2Health News:Visual pattern preference may be indicator of autism in toddlers 2Health News:Visual pattern preference may be indicator of autism in toddlers 3Health News:Study examines association between urban living and psychotic disorders 2Health News:Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens 2
(Date:9/19/2014)... EASTON, Mass. , Sept. 19, 2014 /PRNewswire/ ... "Company") today announced it has received and approved ... Barozyme HT48 instruments and has begun to manufacture ... the first instrument will be ready for shipment ... be built and released at a rate of ...
(Date:9/19/2014)... 19, 2014 Aufgrund der ... äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt auch die ... verfügbar unter pharmaserialisation.com , zeigt die Serialisierungsanforderungen ... in Kraft treten. Für international tätige ... um das "ob", sondern darum, "wann" sie die ...
(Date:9/19/2014)... and CAMBRIDGE, Mass. ... Inc. (PGDx), a provider of advanced cancer ... Medicines , a leader in discovering and developing ... today disclosed the first-ever comprehensive genomic study of ... deadly cancer of the female reproductive system, also ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
Produce clean 0.75 mm round hole without tissue tags. Serrated squeeze action handle....
Target illumination for day and night testing. Glare luminance distance. The Optec 3500 remote control offers flexible positioning during test administration. Each vision tester includes 12 tests sli...
... The CSV- lOOOHGT instrument provides standardized glare testing. ... Vectorvision test faces for the evaluation of glare ... is precisely calibrated to simulate two on-coming halogen ... feet. The glare level can be adjusted to ...
Ruler S/Steel....
Medicine Products: