Navigation Links
Gene Mutations Seem to Make a Leukemia More Deadly
Date:11/10/2010

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Nov. 10 (HealthDay News) -- Researchers have pinpointed a gene with multiple mutations that seems to separate people who die quickly from acute myeloid leukemia (AML) from those who do not.

The findings, appearing in the Nov. 11 issue of the New England Journal of Medicine, could help identify which AML patients are the best candidates for more aggressive initial treatment. The insights might also provide a target for future therapies.

"We have to know the gene before we can design the targeted therapy, and we need to understand the mechanism," explained study senior author Dr. Timothy Ley, a professor of medicine and genetics at Washington University in St. Louis. "The mutations provide a new clue to find out how the mechanism might affect gene regulation in patients with these mutations. Hopefully, [additional studies] will tell us a lot more about how to think about reversing effects of mutations in patients with this disease."

"The whole idea is to move towards personalizing our health-care choices and to do that we have to better understand the pathways that lead to the development and progression of each person's cancer," added Dr. David Rizzieri, director of the hematologic malignancy program at Duke University. "This is a potential major step forward to better understanding the role of this molecular pathway in both the development and progression of AML."

AML is a cancer of the blood-forming cells, affecting about 13,000 Americans every year, 9,000 of whom will die.

Overall, only 20 percent of patients with AML will survive five years but there are three risk groups of patients, each of which confers a different prognosis.

"Favorable" risk patients tend to do better with standard therapy, while those with poor risk need to get a bone-marrow transplant when they go into their first remission, Ley explained.

Then there's the i
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
2. Study shows that mutations in 1 gene cause many cancers
3. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
4. Gene Mutations Up Risk for Cancer in Opposite Breast
5. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
6. Single Lung Tumor Contains 50,000 Mutations
7. Gene Mutations Offer Clues to Autoimmune Disorders
8. Individual mutations are very slow to promote tumor growth
9. Study finds women with triple negative breast cancer and BRCA mutations have lower risk of recurrence
10. Gene Mutations May Blunt Plavixs Effectiveness, Study Finds
11. Unexpectedly small effects of mutations in bacteria bring new perspectives
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Seem to Make a Leukemia More Deadly
(Date:4/17/2015)... Illinois (PRWEB) April 18, 2015 Heritage ... will begin its Supportive Living Week Celebration on April ... on having a healthy mind, body and soul. , ... in McLeansboro, Illinois, serves older adults of all incomes, ... maintain their independence. , Supportive Living Week is observed ...
(Date:4/17/2015)... California (PRWEB) April 17, 2015 ... Dr. Kevin Sadati of the Gallery of ... Orange County’s top beauty experts. The publication focused ... lift, facial stem cell fat grafting, eyelid surgery, laser ... facial plastic surgery has resulted in thousands ...
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
(Date:4/17/2015)... 17, 2015 Enthusiasts of gourmet cuisine and ... April 25, 2015. The event will be held in the ... (201 Monroe Ave NW, Grand Rapids, MI 49503) and will ... Michigan area. Patrons are encouraged to savor the food and ... , This year’s event will feature seven chefs, including:, ...
(Date:4/17/2015)... York, New York (PRWEB) April 17, 2015 ... that allege this class of prescription medications ... a heart attack, stroke or other life-threatening cardiovascular ... underway in U.S. District Court, Northern District of ... by the U.S. Judicial Panel on Multidistrict Litigation ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4
... EpiCept Corporation,(Nasdaq and OMX Nordic Exchange: EPCT) ... be presenting at the 2007 BIO InvestorForum on,October ... the Palace Hotel in San,Francisco, California. Mr. Talley ... http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO ) The presentation will be ...
... Healthcare Services, WASHINGTON, Oct. 3 The American ... override,President Bush,s veto of the State Children,s Health Insurance ... bill by a 265-159 margin. This vote margin,is not ... passed the,measure by a 67-29 margin., "Without this ...
... Million Raised to ... Date, CARLSBAD, ... teaming up,with American Airlines this weekend to support Susan G. Komen for the ... the Four Seasons Resort Aviara and the Del Mar Country Club in,Carlsbad, Calif. ...
... 3 VNUS(R) Medical,Technologies, Inc. (Nasdaq: VNUS ), ... treatment of venous reflux disease, today,announced that it presented ... at 10:00 a.m. ET on October 3, 2007, at ... An archive of the VNUS presentation webcast is ...
... Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ) announced today ... October 10, 2007, at 11:45 a.m. PDT (2:45,p.m. EDT). ... in San,Francisco. Steve Worland, Ph.D., President and Chief ... of Anadys and an update on,its two development-stage product ...
... Web site from Northwood,Health Systems has won three awards ... effort in partnership with the best,Web designers in West ... Web site technology," Northwood President and Chief,Executive Officer Pete ... more than 1,000 accredited,continuing education courses for health care ...
Cached Medicine News:Health News:EpiCept Corporation to Present at the 2007 BIO InvestorForum 2Health News:EpiCept Corporation to Present at the 2007 BIO InvestorForum 3Health News:American Academy of Child and Adolescent Psychiatry Reacts to S-CHIP Veto 2Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 2Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 3Health News:Anadys Pharmaceuticals to Present at BIO InvestorForum 2007 2
(Date:4/17/2015)... Apr. 17, 2015 Research and Markets ... of the "Medical Device Outsourcing - Global ... This report analyzes the worldwide markets ... the following Device Categories: Class I, Class II, ... in the report Include - Radiology, Orthopedic, Neurology, ...
(Date:4/17/2015)... , April 17, 2015 ASSESS ... mutation   is a viable alternative to tumour biopsy   ... in all patients with advanced NSCLC   AstraZeneca ... of plasma circulating tumour DNA (ctDNA) testing for epidermal growth ... advanced non-small cell lung cancer (NSCLC) in clinical practice. [ ...
(Date:4/17/2015)... 17, 2015 Research and Markets ( ... "Medical Oxygen Systems - Global Strategic Business Report" ... the worldwide markets for Medical Oxygen Systems in US$ ... Systems, Oxygen Cylinders & Regulators, and Oxygen Conserving Devices. ... Canada , Japan ...
Breaking Medicine Technology:Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 2Medical Device Outsourcing (Radiology, Orthopedic, Neurology, Cardiology, and Others) Market 2015 - Global Strategic Business Report 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 2"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 4Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2
... PHILADELPHIA, Nov. 7, 2011 The Children,s Hospital of ... Grand Challenges Explorations, an initiative created by the Bill ... test unorthodox ideas that address persistent health and development ... of Rheumatology at Children,s Hospital and Professor of Pediatrics ...
... efforts on behalf of the public and private healthcare industry ... today, according to a new book , "Health Industry ... J. Hicks and Christina Mazzola Nicols of Ketchum , ... The book, released this fall from Jones & Bartlett ...
Cached Medicine Technology:The Children's Hospital of Philadelphia Receives Grand Challenges Explorations Funding 2The Children's Hospital of Philadelphia Receives Grand Challenges Explorations Funding 3New Book Highlights Opportunities for Healthcare Industry Communications 2New Book Highlights Opportunities for Healthcare Industry Communications 3New Book Highlights Opportunities for Healthcare Industry Communications 4New Book Highlights Opportunities for Healthcare Industry Communications 5
Liquichek™ Ethanol/Ammonia Control is a liquid product used to monitor ethanol and ammonia test procedures in the clinical laboratory....
Lyphochek Assayed Chemistry Control requires no special diluent and has good reconstituted stability for enzymes and CO2. It is assayed for most major instruments and methodologies....
Lyphochek Benzo/TCA Control Set B is ideal for monitoring HPLC methods for identification and quantitation of benzodiazepines and antidepressant drugs....
Lyphochek Endocrine Control is a human based product designed to monitor plasma catecholamine testing procedures by HPLC. The analytes are spiked at critical concentrations to cover the dynamic range...
Medicine Products: