Navigation Links
Gene Mutations Offer Clues to Autoimmune Disorders
Date:6/16/2010

Rare variant may lead immune system to attack healthy cells, study finds

WEDNESDAY, June 16 (HealthDay News) -- A new study finds that rare gene variations are more common in people with disorders in which the immune system attacks the body. These autoimmune disorders include rheumatoid arthritis and type 1 diabetes.

Researchers report that the findings could lead to better treatments -- although that's not guaranteed -- and pave the way for scientists to link uncommon genetic variations to other diseases.

The research is focused on mutations in the gene coding an enzyme in charge of a crucial cell in the immune system. The enzyme, called sialic acid acetylesterase, controls the immune system's B cells -- white cells that produce antibodies to fight the foreign proteins of viruses, bacteria and other invaders. If the enzyme fails to rein in the B cells, they may attack the body's healthy cells by mistake.

The study authors compared the genetic makeup of 923 people with common autoimmune disorders to a control group of 648 people without them. They found a genetic variation that interferes with the enzyme in 24 of the participants with autoimmune diseases but just two of the controls.

The gene variant accounts for only about 2 or 3 percent of autoimmune disease cases, but "we are actively investigating other genes in this pathway that may be defective in a larger percentage of patients," said study senior author Dr. Shiv Pillai, an associate professor of medicine at Harvard Medical School and researcher at the MGH Center for Cancer Research, in a hospital news release.

The research appears online June 16 in the journal Nature.

Learn more about autoimmune disorders from the U.S. National Library of Medicine.



-- Randy Dotinga



SOURCE: Massachusetts General Hospital, June 16, 2010, news release.


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Single Lung Tumor Contains 50,000 Mutations
2. Heart Disease Among Childhood Cancer Survivors Tied to Gene Mutations
3. Gene Mutations Up Risk for Cancer in Opposite Breast
4. Breast cancer patients with BRCA mutations 4 times more likely to get cancer in opposite breast
5. Study shows that mutations in 1 gene cause many cancers
6. Gene Mutations Identified for Charcot-Marie-Tooth Syndrome
7. Gene Mutations Behind Brain Reduction
8. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
9. Del Mar Plastic Surgeon Dr. Maurice Sherman Now Offering Natural Breast Implant Alternatives
10. Publix Pharmacy Now Offers Pill Glide, an Innovative New Way for Children and Adults to Take Vitamins, Supplements and Medications
11. Career Training College, Pima Medical Institute, Offering Second Bachelor's Degree Program in Respiratory Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Gene Mutations Offer Clues to Autoimmune Disorders
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare ... program management, will showcase a range of technology and learning solutions at the ... Convention and Expo to be held October 14–18, 2017 at the Mandalay Bay ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... IsoComforter, Inc. ... products, announced today the introduction of an innovative new design of the shoulder pad. ... so you get maximum comfort while controlling your pain while using cold therapy. By ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa ... contributed a medical article to the newly revamped Cosmetic Town journal ... the hair transplant procedure known as Follicular Unit Extraction (FUE). , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and ... 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will ... Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... University of California Berkeley, and other leading institutions in announcing the launch of ... institutions to change the way animals are raised for food. , Founding members ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... for their devotion to personalized service, SMP Pharmacy Solutions announces ... the South Florida Business Journal,s 50 Fastest-Growing Companies, and listed ... national specialty pharmacy has found its niche.  To that end, ... honored by SFBJ as the 2017 Power Leader in Health ... his award in October, Bardisa said of the three achievements, ...
(Date:9/23/2017)... , Sept. 22, 2017 Janssen Biotech, ... complete response letter from the U.S. Food and Drug ... approval of sirukumab for the treatment of moderately to ... indicates additional clinical data are needed to further evaluate ... to severely active RA. ...
(Date:9/19/2017)... 2017   ZirMed Inc ., a recognized leader in ... it has been ranked #1 by its users for the ... 2017 User Survey. ZirMed was recognized as the top-ranked end-to-end ... medical centers over 200 beds and holds one of the ... survey history. ...
Breaking Medicine Technology: